Prevention récidive post-op E Louis

Coment prévenir la récidive post-
opératoire de la maladie de Crohn
Edouard LOUIS
CHU de Liège Bordeaux Juin 2016

•Histoire naturelle
•Traitements/interventions disponibles
•Différents patients, différentes priorités
•Prédiction ou monitoring
•Stratégies intégrées

The natural history of CD
Development of complications over time
0
20
40
60
80
100
diag 13510 15 20 25
penetrating
stricturing
inflammatory
Time (years)
Louis et al. Gut 2001
% of patients

Can we change this in CD?
Nationwide population based cohort study in Denmark including 13185 CD
patients. A decrease in surgery was observed in parallel with an increase in the
use of immunosuppressants and anti-TNF
Rungoe C et al. Gut 2013. doi:10.1136/gutjnl-2013-305607

Postoperative Course of Crohn's Disease
(Rutgeerts P. Gastroenterology.1990)