Section(4(Item(12(
Pharmaetudes(
!"#$%&'$&"()(&'*+
Cryptosporidium,parvum,
!
"#$%&'()*#*'+!,*-!./0(1#/2*3&!*+!(2&--*!,*-!41((0,*&!
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Cryptosporidium!%*+%1689!*--*'+0*22*#*'+!&6!'08*&6!,6!+6$*!
,07*-+0:!;! ,&'-! 2*-! (*2262*-! 9/0+)920&2*-! <*'+9%1(=+*->!,*-!(*2262*-!
*'!$%1--*!,*!250'+*-+0'!7%?2*@!
45*-+!6'*!$"&%&2&&'*+(,%*'%(,-0*@!
A2! *303+*! /26-0*6%-! *-/B(*-!;! C.- hominis!<-+%0(+*#*'+!
)6#&0'>C!C.-parvumC!C.-muris!16!felis@@@!
C.parvum!*-+!%*-/1'-&$2*! ,*! -0#/2*-! ,0&%%)9*-! ()*D!
250##6'1(1#/9+*'+! #&0-! /*6+! /%181E6*%! ,*-! ,0&%%)9*-! /%121'79*-C! ()129%0:1%#*-! *+! %9-0-+&'+*-! F!
+16+!+%&0+*#*'+!()*D!2*-!/&+0*'+-!0':*(+9-!/&%!2*!GAH@!A2!:&0+!*'+%*%!2*!/&+0*'+!,&'-!2*!-+&,*!IAJ.@!45*-+!
,1'(!6'*!/&%&-0+1-*!1//1%+6'0-+*@!
!
3+4$()56(&0&7(*+
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,98*21//*#*'+!
- 2&!(1'+&#0'&+01'!-*!:&0+!/&%!0'7*-+01'!,511(=-+*-!-/1%629-!E60!-1'+!920#0'9-!,&'-!2*-!-*22*-!,*!
25)K+*!-16-!:1%#*!-/1%629*!;!209*!&6!$5"(0+85/-0+9%"-,'6(''(&,+&"&.85/-0*:+
- 0*!%9-*%810%!,*!(*!/&%&-0+*!*-+!25)1##*!*+!2*!$9+&02!<&'0#&63!/%1()*-!,*!25)1##*!LLL>+
- #&0-!2&!+%&'-#0--01'!0'+*%)6#&0'*!M16*%&!6'!%K2*!*--*'+0*2!*'!#020*6!6%$&0'@+
!
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- N5)1##*!-*!(1'+&#0'*!/&%!250'7*-+01'!,511(=-+*-!-/1%629-!<F!/&%10!9/&0--*>!9#0-!/&%!25)K+*!
,&'-!-*-!-*22*-!
- /#/0*+6&,&<=,*+*%+)("*/%!<-*!,9%162*!*'+0B%*#*'+!()*D! 6'!-*62!)K+*C!&6! '08*&6! ,6! +%&(+6-!
,07*-+0:>!
- -*!,9%162*!F!2&!-6%:&(*!,*-!*'+9%1(=+*-!*+!,6%*!,*!OP)!F!QRSQO!M16%-@!
- A'(6$&+01'!()*D!25)1##*!;!T!F!UQ!M16%-!
- &/%B-!0'7*-+01'!16!0')&2&+01'C!2*-+&&/#'%*'!E60!-1'+!,0%*(+*#*'+!(1'+&#0'&'+-!81'+!20$9%*%!O!
-/1%1D1V+*-! ,5*'80%1'! TSP! W#! ,&'-! 2&! 26#0B%*! ,07*-+08*! 7%X(*! F! ,*-!*'D=#*-!*+!,*-!-*2-!
$020&0%*-@! N*-! -+&,*-! ,*! ,98*21//*#*'+! ,6! /&%&-0+*! -1'+! 0'+%&S(*2262&0%*-!&6!-*0'!,56'*!
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- 2*-!-/1%1D1V+*-!20$9%9-!,&'-! 2&! 26#0B%*!,07*-+08*!81'+! /9'9+%*%!,&'-!2*-!(*2262*-!9/0+)920&2*-!
/&%!0'8&70'&+01'!,*!2&!#*#$%&'*!/2&-#0E6*!!
- 1'!8&!&810%!+%&'-:1%#&+01'!*'! %"&$>&2&?%*'!/60-!*'!'/>(2&,%*'!E60!81'+!9(2&+*%!*+!20$9%*%!P!
65"&2&?%*'!,*!:1%#*!&221'79*C!+16+!Y&!&/%B-!/26-0*6%-!(=(2*-!,*!%*/%1,6(+01'!&-*369*!
- (*-!#9%1D1V+*-!81'+!;!
-10+!/&%&-0+*%!,5&6+%*-!(*2262*-!!
-10+! -6$0%! 6'*! ,0::9%*'(0&+01'! -*36*22*!*+!*'7*',%*%! ,*-! 6(/"&7-6=%&/#%*'!*+!,*!
6-/"&7-6=%&/#%*'!,1''&'+! 2*-! #&(%17&#B+*-! *+! 2*-! #0(%17&#B+*-!;! :1%#*-!
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- 2&! :9(1',&+01'! ,1''*%&! '&0--&'(*! F! 6'! D=71+*! E60! -*! +%&'-:1%#*! *'! &&/#'%*!(1'+*'&'+!O!
-/1%1D10+*-@! N511(=-+*! :1%#9! /*6+! ?+%*! -10+! F! /&%10! :0'*! </16%! 0'0+0*%! 2*! (=(2*! ,5&6+1S
Section(4(Item(12(
Pharmaetudes(
0':*-+&+01'>!-10+!F!/&%10!9/&0--*!</16%!?+%*!920#0'9!,&'-!2*-!-*22*-!*+!?+%*!%*-/1'-&$2*!,*!2&!
+%&'-#0--01'>@!
!
@+A&)*+)*+%"-,'6(''(&,+
3B C5'*"D&("'+)*+$-"-'(%*+E+
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- )1##*!;!#020*6!6%$&0'LL!<)K/0+&2C!(122*(+080+9-C!*':&'+-C!80*63@@@>!
!
;B A&)*+)*+/&,%-6(,-%(&,+E+
- )("*/%*+E!,5H!(1'+&#0'9!F!H!-&0'!<11(=-+*!,9MF!-/1%629!%9-0-+&'+!,&'-!25*'80%1''*#*'+>!
- (,)("*/%*+E!/&%!0'7*-+01'!,5*&6!16!,5&20#*'+-!-160229-!
!
F+!0(,(G1*+
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#&M*6%! *-+! 2&! ,0&%%)9*! #&0-! 2598126+01'! ,*! 2&! /&%&-0+1-*! *-+! -16-! 2&!
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+
+
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N&! (%=/+1-/1%0,01-*! /*6+! ?+%*! -'#6$%&6-%(G1*!</1%+*6%-! -&0'->! 16!
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- ,0&%%)9*!LL!;![!F!QR!-*22*-\MC!20E60,*-C!'1'!-&'72&'+*-C!'1'!/%6%2*'+*-C!*+!/&%:10-!/%9-*'(*!,*!
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*3(%9+*%!,*-!11(=-+*-!/26-0*6%-!-*#&0'*-!&/%B-!2&!769%0-1'@!
+
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4*! -1'+! -6%+16+! 0*'+ $-%(*,%'+ JKLM!E60!-1'+!(1'(*%'9-!*'!:1'(+01'!,*!2*6%!+&63!,*!4JO!<16! ,*-!
(&'(9%*63C!+%&'-/2&'+9-C@@@>;!
N+ ;OO+ 66@+E!1'!&!2&!#?#*!98126+01'!E6*!()*D!2*-!0##6'1(1#/9+*'+-!(&%!$1''*!
0##6'0+9!(*2262&0%*!
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$-''*"+-1+'%-)*+QKRSB+
+
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- J0&%%)9*!20E60,*C!/>&05"(8&"6*T!'1'!-&'72&'+*C!0'(1*%(0$2*C!&8*(!/*%+*!20E60,0*''*!]!
QR!N\M!<QR!F!UR!-*22*-!\M>!
- 4*2&! *'+%&0'*! 6'*! /*%+*! ,*! /10,-! 0#/1%+&'+*! &8*(! (&()*30*! <#&07%*6%! *3+%?#*>C!
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- ^*6+! &6--0! -*! (1#/20E6*%! *'! &++*0'+*! $020&0%*! &8*(! ()12&'70+*! '9(%1-&'+*! *+!
()129(=-+0+*! &20+)0&-0E6*! 16! /&%! ,*-! /)9'1#B'*-! ,*! #&2&$-1%/+01'! *+! ,&'-! 2*-! (&-!
*3+%?#*-!/&%!,*-!:1%#*-!0'8&-08*-@!
Section(4(Item(12(
Pharmaetudes(
@B;B;+!"#$%&'$&"()(&'*+$106&,-("*+
- "3(*/+01''*22*!
- _*'(1'+%9*-!21%-!,50':*-+&+01'!,07*-+08*-!#&--08*-@!
- `'!%*+%168*!,*-!11(=-+*-!,&'-!2*!Na.!
- ^&-!,*!+*',&'(*!F!2&!%9#0--01'C!-0!-98B%*!LLL!;!79'9%&20-&+01'!
+
F+R(-7,&'%(/+
FB3+R(-7,&'%(/+)*+$"5'&6$%(&,+
- 420'0E6*!
- %9/&%+0+1'!7917%&/)0E6*!
FB;+R(-7,&'%(/+)*+/*"%(%1)*+E!+
+
U-"-'(%&0&7(G1*+
R-,'+0*'+'*00*'+E+
- 1'! %*()*%()*! /&%! *3&#*'! ,0%*(+! 16! &/%B-! (121%&+01'! 2*-!
11(=+*-!
- /&0&"-%(&,+)*+V(*>0+W*0'*,+;!&/%B-!(1'(*'+%&+01'!&6!:1%#12S9+)*%!;!11(=-+*!:6-)0&!$0*'!80-0$2*!
-6%!:1',!8*%+C!,*!:1%#*!&%%1',0*C!TSP!W#C!F!/&%10!9/&0--*!*+!(1'+*'6!7%&'62*63!
- +*()'0E6*!,*!H*0'*!;!:%1++0-!L!)602*!F!0##*%-01'!;!11(=-+*-!+%B-!%9:%0'7*'+-!
R-,'+0*+0(G1()*+X5X1,-0+&1+I(0(-("*+E!&6--0!11(=-+*-C!#&0-!*3&#*'!+%&6#&+0-&'+!
R-,'+0*+YZS+E!*3(*/+01''*22*#*'+!
Z(&$'(*'+(,%*'%(,-0*'+E+(16/*-!,5&'&/&+)!(121%9*-!F!25>56-%&<#0(,*!;!2*-!(*2262*-!-1'+!,9(&/0+9*-C!/26-!
,5&-/*(+!,*!(*2262*-!*'!$%1--*C!/&%&-0+*!&6!/K2*!&/0(&2!
!
U!C+;!/1--0$2*C!/60-!+=/&7*!#129(62&0%*!+
+
R(-7,&'%(/+(661,&0&7(G1*+E+
_*()*%()*! ,*! (1/%1.7! &8*(! 6'! .(! #1'1(21'&2! &'+0S
(%=/+1-/1%0,06#! *+! #&%E6&7*! /&%! :261%*-(*'(*!;! #9+)1,*-! /*6!
:0&$2*-!
+
[+\"-(%*6*,%+
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M16%-!*-+!*::0(&(*@!b&0-!2*-!"*/>1%*'+'&,%+8"5G1*,%*'!F!25&%%?+!,6!+%&0+*#*'+@!
!
W(%-2&<-,()*!!C]U\SQ4^!;!U7\MC!.cd!'1#0'&+08*!
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I/0%&#=(0'*C!^&%1#1#=(0'*!;!%*()6+*-!-=-+9#&+0E6*-!
!
!
Section(4(Item(12(
Pharmaetudes(
_+U"&$>#0-<(*+
K,)(D()1*00*+E+
+
- /&-!,*!()0#01/%1/)=2&30*!
- %9,60%*!2*-!/1--0$020+9-!,*!(1'+&#0'&+01'!;!)=70B'*!&20#*'+&0%*C!*&6!*'!$16+*022*!/16%!2*-!AJ!
!
!&00*/%(D*+E+
+
- /%1+*(+01'!,*-!%*--16%(*-!&20#*'+&0%*-!,*!+16+*!(1'+&#0'&+01'!:9(&2*!
- &++*'+01'!&63!%9-*&63!,*!,0-+%0$6+01'!,*!25*&6!/1+&$2*!(&%!/&%&-0+*!%9-0-+&'+!&63!+%&0+*#*'+-!
!
1 / 4 100%
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