Transplantation cardiaque
La transplantation cardiaque en
pédiatrie
Franck Iserin
Hôpital Necker, Paris
PEDIATRIC HEART TRANSPLANTATION
Kaplan-Meier Survival by Era
(Transplants: 1/1982-6/2008)
0
20
40
60
80
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Years
1982-1989 (N=846) 1990-1994 (N=1,803)
1995-1999 (N=1,846) 2000-6/2008 (N=3,510)
All p-values significant at p = 0.01
Half-life 1982-1989: 9.5 years; 1990-1994: 11.7 years; 1995-
1999: 14.3; 2000-6/2008: n.c.
Survival (%)
2010
ISHLT
J Heart Lung Transplant. 2010 Oct; 29 (10): 1083-1141
PEDIATRIC HEART TRANSPLANTATION
Kaplan-Meier Survival by AGE (1/1982-6/2005)
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Years
<1 Year (N= 1,682) 1-10 Years (N = 2,432)
11-17 Years (N = 2,561) Overall (N= 6,675)
0-<1 vs. 1-10: p = 0.0017;
0-<1 vs. 11-17: p=0.1104;
1-10 vs. 11-17: p=0.0653
Half-life <1: 15.8 Years; 1-10: 14.2 Years; 11-17: 11.4 Years
Survival (%)
ISHLT 2007
J Heart Lung Transplant 2007;26: 796-807
Boucek et al. J Heart Lung Transplant, 2002!
Survie après transplantation (enfant)!
FREEDOM FROM CORONARY ARTERY VASCULOPATHY
For Pediatric Heart Recipients (Follow-ups: April 1994 - June 2006)
Stratified by Age Group
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8
Years
<1 Year (N =576)
1-10 Years (N = 826)
11-17 Years (N = 793)
p < 0.0001
% Freedom from CAV
ISHLT 2007
J Heart Lung Transplant 2007;26: 796-807
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1
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100%
