La transplantation cardiaque en pédiatrie Franck Iserin Hôpital Necker, Paris
La transplantation cardiaque en
pédiatrie
Franck Iserin
Hôpital Necker, Paris
2016
JHLT. 2016 Oct; 35(10): 1149-1205
Kaplan-Meier Survival
Pediatric Heart Transplants
Median survival (years): <1=20.7; 1-5=18.2; 6-10=14.0; 11-17=12.7
1-5 vs. 11-17: p = 0.0001
6-10 vs. 11-17: p = 0.0312
No other pair-wise comparisons
were significant at p < 0.05.
(Transplants: January 1982 –June 2014)
Adult Heart Transplants
Kaplan-Meier Survival by Era
2016
JHLT. 2016 Oct; 35(10): 1149-1205
Median survival (years):
1982-1991=8.5; 1992-2001=10.4; 2002-2008=11.9; 2009-6/2014=NA
All pair-wise comparisons were significant at p < 0.05.
(Transplants: January 1982 –June 2014)
2016
JHLT. 2016 Oct; 35(10): 1149-1205
Pediatric Heart Transplants
Conditional Kaplan-Meier Survival for Recent Era
All pair-wise comparisons with 11-17 were
significant at p<0.05. No other pair-wise
comparisons were significant at p<0.05.
(Transplants:January 2004 –June 2014)
PEDIATRIC HEART TRANSPLANTS
Kaplan-Meier Survival (Transplants: 1/1982-6/2010)
0
20
40
60
80
100
012345678910 11 12 13 14 15 16 17 18 19 20
Survival (%)
Years
<1 Year (N = 2,396)
1-10 Years (N = 3,512)
11-17 Years (N = 3,695)
Overall (N = 9,603)
Half-life <1: 19.2 Years; 1-10: 15.6 Years; 11-17: 11.9 Years
ISHLT 2012
0-<1 vs. 1-10: p = 0.0041
0-<1 vs. 11-17: p = 0.9859
1-10 vs. 11-17: p = 0.0003
J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095
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