Dr Mohun R.K Bahadoor

Dr Mohun R.K Bahadoor
Consultant
Jean Perrin Comprehensive Cancer Centre of
Auvergne, France

HPV Vaccination
Mohun R. K. Bahadoor, MD
Medical Coordinator Auvergne cancer Network
Centre Jean Perrin, France

Disclosures
•No conflict of interest with vaccine
manufacturers

Glossary
•HPV infection
•Cervical lesions : natural history
•Screening for cervical lesions
•Anti-HPV Vaccination

Human Papillomavirus (HPV)
Common and contagious virus1
Mucosa and skin virus in particular the genitalia
Specific for humans
Non encapsulated Double stranded DNA Virus
Capside comprised of 72 capsomeres
Capsomere : major protein L1 & minor protein L2
Stable Viruses : mutation rate is very low
More than 150 types of human virus described2
Low risk type responsible for benign lesion
High risk virus responsible for cancers
12 HPV oncogenes (IARC 2009, groupe 1)3: 16, 18, 31, 33,
35, 39, 45, 51, 52, 56, 58 and 59
1. Mougin C. et Prétet JL. In Aubin F. et al. Papillomavirus humains; biologie et pathologie tumorale. TEC & DOC et EMinter éditeurs. 2003;15-24
2. Doorbar J et al. Vaccine 2012;30S:F55-70
3. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Biological agents volume 100 B. A review of human carcinogens Lyon, France 2009:p 295
http://monographs.iarc.fr/ENG/Monographs/vol100B/mono100B.pdf (accédé le 14/03/2014)