FDG-PET and liver metastases from colo rectal cancer

18F-FDG PET CT
18F-FDG PET CT
and liver metastases from
and liver metastases from colo colo- -
rectal cancer
rectal cancer
Eric ZERBIB
Eric ZERBIB
CIMEN (
CIMEN (wwww wwww. .cimen cimen. .fr fr) )
Centre Chirurgical Val d
Centre Chirurgical Val d!’ !’Or Or
14 rue Pasteur
14 rue Pasteur
92210 Saint-Cloud
92210 Saint-Cloud
eric
eric. .zerbib zerbib@ @cimen cimen. .fr fr

18F-FDG PET CT
18F-FDG PET CT
and liver metastases from
and liver metastases from colo colo- -
rectal cancer
rectal cancer
Preliminary comments :
Preliminary comments :
!
!FDG PET is not a specific investigation for liver studies. It FDG PET is not a specific investigation for liver studies. It
makes the scanning of the whole body (excepted brain) and is
makes the scanning of the whole body (excepted brain) and is
efficient in the diagnosis of liver metastases including liver
efficient in the diagnosis of liver metastases including liver
metastases from
metastases from colo colo-rectal cancer. -rectal cancer.
!
!FDG PET is not FDG PET is not anatomopatholgy anatomopatholgy ! It investigates ! It investigates glucosis glucosis
metabolism which is special IN MOST OF cancerous cells. This
metabolism which is special IN MOST OF cancerous cells. This
have important consequences for interpretation.
have important consequences for interpretation.

PET and PET-CT and isotopes
PET and PET-CT and isotopes
Background :
Background :
!
!PET : detection of a couple of photons coming from the disintegration PET : detection of a couple of photons coming from the disintegration
of one positron
of one positron
!
!CT : computed tomography CT : computed tomography
!
!PET-CT : makes the fusion of the two acquisitions : but makes PET-CT : makes the fusion of the two acquisitions : but makes
attenuation correction very important to see the deep organs and helps
attenuation correction very important to see the deep organs and helps
us to see the anatomy which cannot be appreciate by PET pictures only
us to see the anatomy which cannot be appreciate by PET pictures only
!
!Radiopharmaceutical : is specific of an organ or a system : FDG, Radiopharmaceutical : is specific of an organ or a system : FDG,
Choline
Choline, F-DOPA, FLT, Rubidium , F-DOPA, FLT, Rubidium

Background
Background
• positron annihilation positron annihilation
with an
with an é électron and lectron and
emission of 2 x 511
emission of 2 x 511 keV keV
photons photons
•
• 18
18F : radioactive isotope
F : radioactive isotope
Half live : 110 min
Half live : 110 min

Cam
Camé éra ra hybride hybride TEP-TDM TEP-TDM
Détecteur TEP Anneau TDM