Electroacupuncture biochimie des émotions

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Bases!neurophysiologiques!dans!les!troubles!psychiques.!
Effets!de!l’(électro)acupuncture!sur!l’homéostasie!des!neuromédiateurs.!!
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Références.!
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!839:"(*;#2%29(,-0#<&06*-20#<5,0#%(#-(;-(#7"3'&(,,(,-#<*#%&'"(#=#
>%(6-"356*7*,6-*"(4#5#7"56-&65%#95,*5%#?#"(03*"6(4#@5A3".#)1*"61&%%#B&'&,+0-3,(4#CDDE.#
B5#:50(#<(#<3,,2(0#<*#)!#F39#<(#6(-#3*'"5+(#63,-&(,-#-3*-(0#%(0#"2G2"(,6(0#<(0#2-*<(0#
H*&#03*0I-(,<(,-#%(#-(;-(#<(#6(#-"5'5&%.#
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Conclusions!
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B(0#75-&(,-0#H*&#(;72"&9(,-(,-#<(#%5#"(%5;5-&3,#(-#9J9(#<*#7%5&0&"#%3"0#<K*,(#
025,6(#<K56*7*,6-*"(#,(#03,-#750#<(0#950361&0-(0#L##
@5%+"2#*,#5775"(,-#75"5<3;(4#%K5+"(00&3,#7"3'3H*2(#75"#%(0#5&+*&%%(0#61(M#<(0#
75-&(,-0#(,#<2-"(00(#70A613%3+&H*(#(;("6(#03*'(,-#*,#(GG(-#positif#0*"#%(*"0#293-&3,0.#
B(0#2-*<(0#<(0#CD#<(",&N"(0#5,,2(0#3,-#(,#(GG(-#<293,-"2#6399(,-#-3*-(#
56*7*,6-*"(#&,G%*(,6(#%5#7"3<*6-&3,4#%K56-&3,#0*"#%(*"0#"26(7-(*"0#(-#%K2%&9&,5-&3,#<(#
-3*0#%(0#neuromédiateurs#63,,*0.#
B3&,#<(#7"3'3H*("#<(0#'5"&5-&3,0#5,5"61&H*(04#%K56*7*,6-*"(#"2-5:%&-#
l’homéostasie#7("-*":2(#75"#615H*(#-"3*:%(#293-&3,,(%.#>,#(GG(-4#%(0#63,6(,-"5-&3,0#(-#
%(0#(GG(-0#0*"#%(0#"26(7-(*"0#<(0#<&GG2"(,-0#,(*"392<&5-(*"0#&97%&H*20#,(#'5"&(,-#H*(#0&#
&%0#03,-#7("-*":204#6399(#%(#<293,-"(#%K5:0(,6(#<K(GG(-#61(M#%(0#'3%3,-5&"(0#05&,0.##
O3*"#0K(,#63,'5&,6"(4#&%#0*GG&-#<K3:0("'("#%(0#93<&G&65-&3,0#neuro?anatomiques#
(-#biochimiques#7"37"(0#5*#0-"(004##P#%K5,;&2-24##P#%5#<27"(00&3,4##P#%K&,039,&(#3*#5*#
0('"5+(#P#<&GG2"(,-(0#<"3+*(0.##
B(0#2-*<(0#06&(,-&G&H*(0#<293,-"(,-#6399(,-#l’électroacupuncture#93<&G&(#%(0#
6&"6*&-0#,(*"3I5,5-39&H*(0#(-#"2+*%(#%(0#'5"&5-&3,0#:&361&9&H*(0#&97%&H*2(0#<5,0#
6156*,#<(#6(0#-"3*:%(0#293-&3,,(%0.##
!5,0#6(0#2-*<(04#%K*-&%&05-&3,#<(#%K2%(6-"356*7*,6-*"(#7("9(-#<(#0-&9*%("#<(0#
73&,-0#<K56*7*,6-*"(#<(#95,&N"(#quantifiable##et#reproductible4#6(#H*&#"273,<#9&(*;#
5*;#6"&-N"(0#<(#%5#7(,02(#06&(,-&G&H*(#366&<(,-5%(.#
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Q&+*"(#R.##S-"(00#(-#,(*"371A0&3%3+&(.#
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Stress!aigu!
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SNC!
Plasma!
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1.#NA#
diminue#
#&#5HT#
augmente#
2.#NA#&#Adr##
augmentées#
3.#β#EP#
ACTH#
Cortisol#
4.!Cortisol!
augmenté!
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Stress!chronique!
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SNC!
Plasma!
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2.#NA#
diminué#
#&#5HT#
épuisé#
4.#Hypercortisolémie#
3.#β#EP#:#tolérance#
&#ACTH#augmenté#
1.!Feed8Back!
interrompu!
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5.#Apoptose#
hippocampe#
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&!
hyperorthosympathisme!

Discussion!des!résultats.!
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Anxiété!aiguë!:!le!circuit!de!la!peur!surpasse!celui!du!renforcement!&!du!plaisir!!
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Circuit!de!renforcement!&!du!plaisir!
Circuit!de!la!peur!
1.!Aire!tegmentale!ventrale!:!DA!
2.!Locus!Coeruleus!:!NA!
2.!Noyaux!Raphés!:!5HT!
Rec!5HT2>3!
Rec!5HT1!
3.!CRH!
GABA!
4.!CCK4!
5.!NPY!
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Anxiété!chronique:!emballement!du!circuit!de!la!peur!
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Circuit!de!renforcement!&!du!plaisir!
Circuit!de!la!peur!
1.!Aire!tegmentale!ventrale!:!DA!
2.!Locus!Coeruleus!:!NA!
2.!Noyaux!Raphés!:!5HT!
Rec!5HT2?3!
Rec!5HT1!
3.!CRH!
GABA!
4.!CCK4!
5.!NPY!
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