Transplantation cardiaque

Transplantation
cardiaque
CSB Cardiaque
Danny Mireault
19 octobre 2016

! DIVULGATION
! N = 0

Question 1
! Regarding the transplanted heart:
a) Resting ventricular function is depressed
b) Cardiac output increases faster in response to
exercise than a normal heart
c) Lower heart rate at rest
d) Frank-Starling response is preserved

Question 2
! Which of the following drugs will increase the heart
rate in the transplanted heart?
a) Epinephrine
b) Atropine
c) Pancuronium
d) Propranolol
e) Edrophonium

Perspective historique
! 1ère transplantation cardiaque
! 1967 par Christiaan Barnard
! Afrique du Sud
! Immunosuppression inadéquate
! Regain 1980s (cyclosporine 1981)
! 2011 – 100 000e transplantation
! Facteur limitant:
! # donneurs
! Amélioration constante survie
! 90% à 1 an
! 75% à 7 ans
! Taylor et al, 2007