Le cancer de la prostate et la TEP

LE CANCER DE LA PROSTATE
ET LA TEP
PERSPECTIVES
PERSPECTIVES
Dr Caroline Rousseau

TEP: Radiopharmaceutiques Fluorés
Métabolisme des glucidesMétabolisme des glucides
1818FF--FluoroFluoro--déoxyglucose (FDG)déoxyglucose (FDG)
Métabolisme des lipides Métabolisme des lipides
1818FF--cholinecholine
Biodistribution
différente

In 6 studies
47 925 patients
Pooled prevalence of incidental prostatic FDG uptake was
1.8% (95%CI: 1.3-2.3%)
Pooled
risk
of
malignancy
in
patients
with
incidental
PREVALENCE AND RISK OF MALIGNANCY OF
PROSTATIC INCIDENTAL UPTAKE OF FDG
Pooled
risk
of
malignancy
in
patients
with
incidental
prostatic FDG uptake verified by biopsy was 62%
(95%CI: 54-71%)
Conclusion: Incidental peripheral prostatic FDG uptake
might carry a significant probability of malignancy
Bertagna F, et al. Nuklearmedizin. 2014

All benign and malignant prostate cells are characterized by a
dominant uptake of fatty acid compared with glucose
Liu Y. Anticancer Res 30: 369 - 374, 2010.
18FDG
Much higher sensitivity for the detection of metastatic lesions
than for primary prostate cancer, which may result from the
progression of the energetic metabolism in metastatic lesions
compared with the primary lesion; increased cell proliferation
and accelerated glucose metabolism
LIU Y. ONCOLOGY LETTERS 7: 2013-2018, 2014

Récidive post radiothérapie, PSA à 2,2 et Gleason initial 9
LNI para-aortic +