Utilisation des cytokines (en dehors des facteurs de croissance

11 mars 2016
Dr Sarah Dumont
Oncologue médicale, MD, PhD
Olivier Mir and Axel Le Cesne
Epidémiologie des
sarcomes
Réseaux de référence

Originedusarcome?
dugrec“sarx” =“chair”
1er
cancerdel’Histoire
DavidARetal.,NatRevCancer.2010Oct
CapassoLL,IntJCancer.2005Jan

Adipocytic tumours
Well deifferentiated / dedifferentiated liposarcoma
Myxoid / round cell liposarcoma
Pleomorphic liposarcoma
…..
Fibroblastic / myofibroblastic tumours
Fibromatosis (desmoid)
Solitary fibrous tumour / haemangiopericytoma
Low grade myofibroblastic tumour
Infantile fibrosarcoma
Adult fibrosarcoma
Mixofibrosarcoma
…..
So-called fibrohistiocytic tumours
Pleomorphic MFH / Undifferentiated pleomorphic sarcoma
…..
Smooth muscle tumours
Leiomyosarcoma
…..
Skeletal muscle tumours
Embryonal rhabdomyosarcoma
Alveolar rhabdomyosarcoma
Pleomorphic rhabdomyosarcoma
Vascular tumours
Epithelioid haemangioendothelioma
Angiosarcoma of soft tissue
…..
Chondro-osseous tumours
Mesenchymal chondrosarcoma
Extraskeletal osteosarcoma
Tumours of uncertain differentiation
Synovial sarcoma
Epithelioid sarcoma
Alveolar soft part sarcoma
Clear cell sarcoma of soft tissue
Extraskeletal myxoid chondrosarcoma
Extraskeletal Ewing tumour
Desmoplastic small round cell tumour
Extra-renal rhabdoid tumour
Malignant mesenchymoma
Neoplasms with perivascular epithelioid cell differentiation (PEComa)
Intimal sarcoma
Toutsitepossible

• Sarcome20%descancerssolides
pédiatriques
• Moinsde1%descancersdel’adulte
• Sarcomesdetissusmoussurtout
• 13%sarcomesosseux
• Agemoyen60ans
SEERdata1973‐2008et
BurninghamZetal.ClinSarcomaRes.2012

00.2 0.4 0.6 0.8 11.2
GIST
Liposarcomas
SarcomaNOS
Leiomyosnonut.
Kaposi
DermatofibroS
UterineLMS
MFH
Myxofibrosarcomas
Rhabdomyosarcomas
Synovialosarcomas
Ewingsarcomas
Angiosarcomas
FibromyxoidSarcomas
MPNST
Fibrosarcomas
Solitaryfibroustumors
OsteoS
Incidence/100,000/yr
Others
Environ4000nouveauxcasparanenFrance
Plusde80histotypesdesarcomes…