IXème SYMPOSIUM ICSN « CANCER : CIBLES, MOLECULES ET THERAPIES » CANCER: TARGETS, MOLECULES AND THERAPIES 10-11 JUIN 2004 Salle de la Terrasse, Gif-sur-Yvette, France Scientific Committee : J.-Y. Lallemand, D. Louvard , P. Potier. Organizing Committee: T. Cresteil, R.H. Dodd, D. Guénard, F. Guéritte, E. Guittet, E. Jacquet. JEUDI 10 JUIN 2004 08H15 Accueil des participants (Greeting of participants) 09H00 Discours d’ouverture (Opening address) : Jean-Yves LALLEMAND ASPECTS CLINIQUES : NOUVELLES STRATEGIES CLINICAL ASPECTS : NEW STRATEGIES CHAIRMAN : Jean-Yves LALLEMAND 09H15 – Michel MARTY (Institut Gustave Roussy, Paris, France) “New Trends in Development of Antineoplastic Agents” 10H05 – Dominique BELLET (Université René Descartes, Paris , France) « From Cancer Research to Drug Therapy!: Deciphering Advances from the Hype » 10H55 Pause/ Break 11H10 – Thierry CRESTEIL (ICSN-CNRS Gif-sur-Yvette, France) “Activation/Inactivation of Anti-Cancer Drugs” 11h40 – Alain COMMERÇON (Aventis Pharma, Vitry-sur-Seine, France) “Anticancer Drugs with Improved Targeting Properties” 12H30 – Repas/ Lunch 14H00 – Session Affiches / Poster Session SUBSTANCES NATURELLES ET ANTICANCEREUX NATURAL PRODUCTS AND ANTICANCER DRUGS CHAIRMAN : Susan P. C. COLE 15H00 – Françoise GUÉRITTE (ICSN-CNRS, Gif-sur-Yvette, France) « Natural Substances in Cancer Chemotherapy » 15H30 – Karl Heinz ALTMANN (Institute of Pharmaceutical Sciences, ETH, Zurich, Suisse) “Epothilones as Lead Structures for Anticancer Drug Discovery” 16H20 – Pause/ Break 16H35 – Craig CREWS (Yale University, New Haven, USA ) « A Small Molecule Approach to Target Identification and Validation » VENDREDI 11 JUIN 2004 NOUVELLES CIBLES (1) NEW TARGETS (1) CHAIRMAN : Daniel LOUVARD 09H15 – Susan P. C. COLE (Division of Cancer Biology & Genetics, Queen’s University, Kingston, Canada ) « An Update on the Structure and Pharmacology of the ABC Drug and Organic Anion Transporter, MRP1.» 10H05 – John A. HICKMAN (Institut de Recherche SERVIER, Croissy-sur-Seine, France) « Finding Molecular Targets for Cancer Chemotherapy » 10H55 – Pause/ Break 11H10 – Jacqueline CHERFILS (Lab. d’Enzymologie et Biochimie Structurale, CNRS , Gif-sur-Yvette, France) « New Concepts for Inhibition of G Proteins » 12H00 – Jean-Yves LALLEMAND (ICSN-CNRS, Gif-sur-Yvette, France) «! Cystic Fibrosis and Cancer : the Key Role of ABC Transporters» 12H30 – Repas/ Lunch 14H00 – Session Affiches / Poster Session NOUVELLES CIBLES (2) NEW TARGETS (2) CHAIRMAN : Pierre POTIER 15H30 – Yves POMMIER (Laboratory of Molecular Pharmacology, NCI, Bethesda, USA) « Genome Targeting with Topoisomerase Inhibitors » 16H20 – Anna KRUCZYNSKI (Laboratoire Pierre Fabre, Castres, France) “Tafluposide, a Novel Inhibitor of Topoisomerases I and II, Exhibits DNA Repair Inhibition Properties.” 17H10 – Daniel LOUVARD (Institut Curie, Paris, France) « Applications of murin models of spontaneous intestinal tumors for the development of new therapeutic approaches » 18H00 – Clôture / Closing remarks : Jean-Yves Lallemand SITE!: http://www.icsn.cnrs-gif.fr