Bulletin électronique de veille Cancer Environnement N°13 du 19/11/2014 Ce bulletin de veille signale mensuellement une sélection de documents identifiés dans le cadre de la veille cancer environnement. La méthodologie mise en œuvre est présentée dans la fiche du site cancer environnement : http://www.cancer-environnement.fr/334-Veille-scientifique.ce.aspx Publications récentes Smoking, alcohol, diabetes, obesity, socioeconomic status, and the risk of colorectal cancer in a population-based case-control study. Tabagisme, alcool, diabètes, obésité, statut socio-économique, et risque de cancer colorectal dans une étude cas-témoins en population générale. Boyle T et al., Cancer Causes Control. 2014 Oct PURPOSE: Although previous research has identified factors that may determine willingness to participate in research, relatively few studies have attempted to quantify the impact non-participation may have on exposuredisease associations. The aims of this study were to (a) investigate the associations between smoking, alcohol, diabetes, obesity, and socioeconomic status and the risk of colorectal cancer in a case-control study (59.7 and 47.2 % response fractions among cases and controls, respectively); and (b) perform sensitivity analyses to examine the possible influence of non-participation. METHODS: Logistic regression was used to estimate the exposure-disease associations. We then investigated the associations between various demographic and health factors and the likelihood that an individual would participate in the case-control study and then performed two sensitivity analyses (sampling weights and multiple imputation) to examine whether non-participation bias may have influenced the exposure-disease associations. RESULTS: The exposures alcohol, smoking, and diabetes were associated with an increased risk of colorectal cancer. We found some differences between cases and controls when examining the factors associated with the participation in the study, and in the sensitivity analyses, the exposure-disease associations were slightly attenuated when compared with those from the original analysis. CONCLUSION: Non-participation may have biased the risk estimates away from the null, but generally not enough to change the conclusions of the study. Objectively measured physical activity and cognitive functioning in breast cancer survivors. Mesures objectives de l’activité physique et du fonctionnement cognitive chez des femmes ayant eu un cancer du sein. Marinac CR et al., J Cancer Surviv. 2014 Oct PURPOSE: 1 This study aimed to explore the relationship between objectively measured physical activity and cognitive functioning in breast cancer survivors. METHODS: Participants were 136 postmenopausal breast cancer survivors. Cognitive functioning was assessed using a comprehensive computerized neuropsychological test. Seven-day physical activity was assessed using hip-worn accelerometers. Linear regression models examined associations of minutes per day of physical activity at various intensities on individual cognitive functioning domains. The partially adjusted model controlled for primary confounders (model 1), and subsequent adjustments were made for chemotherapy history (model 2) and body mass index (BMI) (model 3). Interaction and stratified models examined BMI as an effect modifier. RESULTS: Moderate-to-vigorous physical activity (MVPA) was associated with information processing speed. Specifically, 10 min of MVPA was associated with a 1.35-point higher score (out of 100) on the information processing speed domain in the partially adjusted model and a 1.29-point higher score when chemotherapy was added to the model (both p < 0.05). There was a significant BMI × MVPA interaction (p = 0.051). In models stratified by BMI (<25 vs. ≥25 kg/m2), the favorable association between MVPA and information processing speed was stronger in the subsample of overweight and obese women (p < 0.05) but not statistically significant in the leaner subsample. Light-intensity physical activity was not significantly associated with any of the measured domains of cognitive function. CONCLUSIONS: MVPA may have favorable effects on information processing speed in breast cancer survivors, particularly among overweight or obese women. IMPLICATIONS FOR CANCER SURVIVORS: Interventions targeting increased physical activity may enhance aspects of cognitive function among breast cancer survivors Adolescents and young adult cancer survivors: exercise habits, quality of life and physical activity preferences. Adolescents et jeunes adultes ayant eu un cancer : habitudes, qualité de vie et préférence en matière d’activité physique. Murnane A et al., Support Care Cancer. 2014 Oct INTRODUCTION: Given the decades of survivorship for adolescent and young adult (AYA) cancer survivors, it is important to promote behaviours that enhance physical and mental well-being and quality of life (QoL). The purpose of this study was to explore the exercise programming preferences and information needs of AYA survivors and to examine the impact of a cancer diagnosis on physical activity behavior and QoL. METHODS: Participants aged 15-25 years at time of diagnosis and referred to a specialist AYA cancer service between January 2008 and February 2012 were recruited. Eligible participants were mailed a self-administered questionnaire assessing demographic and disease-related information, physical activity levels over time and exercise information preferences. QoL was measured using the Assessment of Quality of Life-6D (AQoL-6D). RESULTS: Seventy-four (response rate 52 %) participants completed the questionnaire. The mean age was 23 years with 54 % female, with prevalent diagnoses included hematological malignancy (45 %) and sarcoma (24 %). Results indicated a significant reduction in the average minutes of physical activity post diagnosis (p = <0.001) and during treatment (p = <0.001). AYA who met public health physical activity guidelines (n = 36) at questionnaire completion had significantly higher QoL than those not meeting the guidelines (n = 38) (median (Mdn) = 0.87, interquartile range (IQR) = 0.73 to 0.98 and Mdn = 0.81, IQR = 0.57 to 0.93, respectively; p = 0.034). Most participants wanted exercise information at some point after diagnosis (85 %) but many did not receive any information (45 %). CONCLUSIONS: Findings suggest that AYA with cancer experience a significant impact on physical activity levels and QoL. Moreover, survivors experience considerable difficulty returning to premorbid levels of activity. Our study 2 suggests that interventions promoting physical activity and healthy lifestyle behaviours would be well accepted within this population and may be essential to improve their long-term health and QoL during survivorship. Active cigarette smoking and risk of breast cancer. Tabagisme actif et risque de cancer du sein Catsburg C et al., Int J Cancer. 2014 Oct Although epidemiological evidence on the role of active cigarette smoking in breast cancer risk has been inconsistent, recent literature supports a modest association between smoking and breast cancer. This association is particularly observed in women who smoke for a long duration, or who smoke for a long time prior to their first pregnancy. Here, we provide updated results on cigarette smoking and breast cancer risk in the Canadian National Breast Screening Study (NBSS). The NBSS is a large cohort of 89,835 women, aged 40-59, who were followed for a mean of 22.1 years, resulting in the ascertainment of 6,549 incident cases of breast cancer. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association of cigarette smoking variables with breast cancer risk. We found breast cancer to be associated with duration (40 years vs. 0: HR = 1.57; 95%CI = 1.29-1.92), intensity (40 cigarettes per day vs. 0: HR = 1.21; 95%CI = 1.04-1.40), cumulative exposure (40 pack-years vs. 0: HR = 1.19; 95%CI = 1.06-1.13) and latency (40 years since initiation vs. 0: HR = 1.19; 95%CI = 1.10-1.53) of cigarette smoking. Number of years smoked prior to first full-term pregnancy was associated with higher risk of breast cancer than comparative years smoked postpregnancy (among parous women, 5 years pre pregnancy vs. 0: HR = 1.18; 95%CI = 1.10-1.26). These results strongly support a role for cigarette smoking in breast cancer etiology and emphasize the importance of timing of this exposure. 3 Actualités et lettres d’information des acteurs Santé Environnement Région Rhône-Alpes National Agence Régionale de Santé Rhône-Alpes Agence nationale de sécurité sanitaire, de l’alimentation, de l’environnement et du travail Air Rhône-Alpes Bulletin de veille bibliographique Nota Bene Cancer de l’Institut National du Cancer (INCa) Lettre d’information de l’INCa Espace Régional de Santé Publique RhôneAlpes Institut national de recherche en sciences et technologies pour l’environnement et l’agriculture Fédération Rhône-Alpes de Protection de la Nature Lettre d’information de l’Institut National de Recherche et de Sécurité pour la prévention des accidents du travail et des maladies professionnelles Institut de Recherche en Santé Publique Lettre d’information “Ademe et vous” Lettre Santé-Environnement Rhône-Alpes de l’ORS Rhône-Alpes Lettre d’information de l’IReSP La lettre de la Société Française de Santé Environnement Société Française de Santé Publique Bulletin Flash e-mail SFSP Société Française de Médecine du Travail Nos partenaires Avec soutien de : Pour tout abonnement/désabonnement à cet e-bulletin ou pour nous faire part d'informations à diffuser dans les prochains numéros, n’hésitez pas à nous écrire à l'adresse suivante : [email protected] Afin de respecter la législation sur la propriété intellectuelle, le bulletin de veille électronique renvoie l’internaute à la source d’origine de chacune des ressources répertoriées. 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