Are gut hormones responsible for the decrease of

Areguthormonesresponsibleforthedecreaseofappetitivebehaviourforsweetandfatty
foodsaftergastricbypasssurgery?
SophieMeillona,b,c,d,SabrinaN.Jacksond,AlexanderD.Mirase,KarlNeffd,CarelW.leRouxd,f.
aCNRSUMR6265CentredesSciencesduGoûtetdel'AlimentationF‐21000,Dijon,France
bINRAUMR1324CentredesSciencesduGoûtetdel'AlimentationF‐21000,Dijon,France
cUniversitédeBourgogne,UMRCentredesSciencesduGoûtetdel'AlimentationF‐21000,Dijon,
France
dExperimentalPathology,ConwayInstitute,SchoolofMedicineandMedicalScience,University
CollegeDublin
eMolecularandMetabolicImagingGroup,MRCInstituteofClinicalSciences,ImperialCollegeLondon,
HammersmithHospital,LondonW120NN,UnitedKingdom
fInvestigativeScience,ImperialCollegeLondon,UK
Introduction:Gastricbypasssurgery(RYGB)decreasespreferenceforsweetandfattyfoods,
buttheunderlyingmechanismisnotknown.Thisstudyaimedtoinvestigatetheroleofthe
exaggeratedsatietyguthormonereleaseonappetitiverewardofsweetandfattytasteafter
RYGB.
Method:13patientsthathaveundergonepreviousRYGBsurgery(>6months)and13normal
weightcontrolsparticipatedinadouble‐blindplacebo‐controlledtrialcomparingtheeffect
ofsubcutaneousinjectionsofsomatostatinanalogue(octreotide)whichblockssatietygut
hormoneresponses,andsaline(control)ontheappetitiverewardvalueofsweet‐fat
candies.Appetitiverewardwasmeasuredusingtheprogressiveratiotaskwhereparticipants
havetodoprogressivelymoreworkbyclickingamousebuttoneachtimetoobtainacandy
reinforcer.
Results:Inthisongoingstudy,9RYGBpatientsand5controlsubjectshavealreadybeen
assessed.Therewerenostatisticallysignificantdifferencesinthemedianoftotalnumberof
clicksbetweennormalweightcontrolandRYGBpatientsinthesalinecondition(p=0.89).
Themedianoftotalnumberofclickswasnotdifferentbetweensalineandoctreotide
conditions(p=0.62)incontrolsubjectsbutshowedatrendtobehigherinoctreotide
comparedtothesalineconditioninRYGBpatients(p=0.09).
Conclusion:Thepreliminaryresultsofthisnovelmechanisticstudysuggestthatgut
hormonesmayplayaphysiologicalroleinthereductionoftheappetitiverewardvalueof
sweet/fattytaste.Theunderstandingofthismechanismmayleadtoeffectivenon‐surgical
treatmentsthataimtopromotehealthierfoodpreferencesinobesity.