Tonsil

Histoire naturelle de l’infection à papillomavirus
humain dans les amygdales :
du tissu sain au cancer
Jean-Damien Combes1
pour Silvia Franceschi1, Christine Clavel2et Jean Lacau Saint Guily3
1International Agency for Research on Cancer, Lyon, France
2INSERM UMR-S 903 / Université de Reims Champagne-Ardenne / CHU Reims, Laboratoire Pol-Bouin, Reims, France
3Service d'ORL et chirurgie cervico-faciale, Hôpital Tenon AP-HP, Paris, France

Study of human Papillomavirus and
precancerous Lesions In the Tonsil
SPLIT study
Methods
- Cross-sectional study
- 20 centres in France (2012-2016)
- Tonsillectomy for non-cancer reasons
- Gargling specimens before surgery
- Detection of infectious agents
- Cytological and histological precancerous lesions
http://split.iarc.fr/

1. HPV infection in non-cancerous tonsils
2. HPV-induced lesions in the oropharynx

HPV infection in non-cancerous tonsils
Sample tested
Age class M/F
Total
0-14 15-24 25-34 35+
Tonsil brushing
139 169 191 193
314/378
692
Gargling
-89 90 89
121/147
268
HPV-DNA detection test: Luminex®IARC E7-MPG (21 HPV types) (T. Gheit, M. Tommasino)
4

HPV infection in non-cancerous tonsils
SPLIT study final results (submitted)
HPV DNA detection test: IARC E7-MPG platform