Programme / Agenda (Auditorium Jacques-Genest et salle André-Barbeau) Mardi 2 avril - Tuesday, April 2 13 h Accueil des participants et installation des affiches - Attendee greeting and poster installation 13 h 45 Mot d’ouverture / Opening remarks Tarik Möröy (Président et directeur scientifique /President and Scientific Director, IRCM) Session 1: Biologie des Réseaux / Network Biology (Président / Chair: Marlene Oeffinger, IRCM) 14 h John Aitchison, Institute for Systems Biology, Seattle Biomedical Research Institute Nuclear Pore Complex Mediated Control of Chromatin 14 h 40 Thomas Kislinger, MaRS Centre, University of Toronto Plasma Membrane Proteomics: Stem Cell Signatures & Insights into Cardiac Biology 15 h 20 Guillaume Diss, Université Laval (Superviseur / Supervisor: Christian R. Landry) A Systematic Approach for the Genetic Dissection of Protein Complexes in Living Cells (Conférencier sélectionné parmi les résumés / Speaker selected from abstracts) 15 h 40 Pause-café et visionnement des affiches / Coffee break and poster viewing (Hall d’entrée / Lobby) 16 h Michael Tyers, IRIC, Université de Montréal Chemical Biology of the Ubiquitin System 16 h 40 Amy Caudy, Donnelly Centre, University of Toronto Discovery in the Metabolic Network by Genomics and Full Scan Metabolomics 17 h 20 Benoit Coulombe, IRCM, Université de Montréal Mapping the Human Methyltransferasome Reveals the Existence of a PTM Code that Targets Molecular Chaperones to Regulate Functional Organisation of the Proteome Mercredi 3 avril - Wednesday, April 3 Session 2: Génomique Médicale et Évolutive / Medical and Evolutionary Genomics (Président / Chair: Jacques Archambault, IRCM) 9h Igor Jurisica, Ontario Cancer Institute, University of Toronto Network-Based Characterization of Drug-Regulated Genes, Drug Targets, & Drug Toxicity 9 h 40 Mike Hallett, The Rosalind and Morris Goodman Cancer Research Centre, McGill University Prognosis in Breast Cancer: the Illusion of Accuracy 10 h 20 Pause-café /Coffee Break 10 h 40 Philip Awadalla, CHU Sainte-Justine Research Center, Université de Montréal CARTaGENE: A Population Based approach to systems genomics of quantitative traits 11 h 20 Nada Jabado, McGill University Health Center When Genetics meet Epigenetics: A New Option for Therapy in Pediatric High-Grade Astrocytomas? 12 h Benjamin Haibe-Kains, IRCM, Université de Montréal Prognostic and Predictive Value of Random Biomarkers in Cancer 12 h 30 Lunch (salle 255) 13 h Session d’affiches / Poster Session 1 Programme / Agenda (Auditorium Jacques-Genest et salle André-Barbeau) Session 3: Biologie des ARN / RNA Biology (Président / Chair: Eric Lécuyer, IRCM) 14 h Nahum Sonenberg, The Rosalind and Morris Goodman Cancer Research Centre, McGill University Translational Control of Cancer and Autism 14 h 40 Timothy Hughes, Donnelly Centre, University of Toronto A Compendium of RNA-Binding Protein Motifs for Analysis of Gene Regulation 15 h 20 Daniel Zenklusen, Université de Montréal Characterization of Antisense RNA-Mediated Transcriptional Gene Silencing in Yeast (Conférencier sélectionné parmi les résumés / Speaker selected from abstracts) 15 h 40 Pause-café / Coffee Break 16 h Christopher Burge, Massachusetts Institute of Technology Dynamics of Alternative Splicing and Translation 16 h 40 Jérôme Waldispühl, McGill Centre for Bioinformatics, McGill University Exploring the RNA Mutational Landscape 17 h 20 Mot de conclusion et départ / Concluding remarks and departure Francois Robert (Directeur, axe de recherche en biologie des sytèmes et chimie médicinale / Director, Systems Biology and Medicinal Chemistry research division, IRCM) 2 Séance d’affiches / Poster Session (1) AGUILAR, Lisbeth C., IRCM (Superviseure:Marlene Oeffinger) Determining the temporal order of pre-ribosomal assembly (2) AYASHI, Sammy, Université de Montréal (Superviseur: Dindial Ramotar) Identification of Histone variants defective in cellular response to the immunosuppressant and anticancer drug rapamycin (3) AZIZI, Afnan, Université d’Ottawa (Superviseur: Mads Kearn) Titre à déterminer / Title to be determined (4) BERGALET, Julie, IRCM (Superviseur: Éric Lécuyer) Defining the role and the mechanism of RNA localization to the mitotic apparatus (5) BERLIVET, Soizik, IRCM (Superviseure: Marie Kmita) Role of chromatin organization in HoxA gene regulation (6) CELTON, Magalie, IRIC, Université de Montréal (Superviseur: Brian Wilhelm) Expression of GATA2 in normal karyotype acute myeloid leukemia (7) CLÉROUX, Katherine, IRCM (Superviseur: Marlene Oeffinger) Linking Regulation and Spatial Progression of Pre-Ribosomes (8) CODY, Neal, IRCM (Superviseur: Éric Lécuyer) Defining the role for mRNA localization in the regulation of epithelial cell polarity (9) DOSTIE, Starr, IRCM (Superviseur: Yvan Guindon) Diastereoselective Synthesis of Nucleoside Analogues via Synthesis and Cyclization of Acyclic Precursors (10) EAR, Po Hien, Lady Davis Institute (Superviseur: Stéphane Richard) Sam68 regulates the alternative splicing of a key Notch signaling factor required for lung cancer (11) HELNESS, Anne, IRCM (Superviseur: François Robert) Effect of Gfi1 absence on the epigenome of mouse hematopoietic stem cells and progenitor cells (12) IAMPIETRO, Carole, IRCM (Superviseur: Éric Lécuyer) mRNA nuclear Retention as a Novel Facet of the DNA Damage Response in Drosophila (13) JERONIMO, Célia, IRCM (Superviseur: François Robert) FACT and Spt6 Act as a Histone Triage Agents Preventing Accumulation of H2A.Z within Transcribed Regions (14) KODIHA, Mohamed & MAHBOUDI, Hicham, Université McGill (Superviseur: Ursula Stochaj) Methods developed for the automated quantification of granular cell compartments reveal novel biological properties of stress granules (15) LEBEDEV, Anton, IRCM (Superviseur: François Robert) Mapping and Quantifying the Transcriptome of Murine HSCs and Hematopoietic Progenitors by RNA-Seq: The Role of the Transcription factor Gfi1 3 (16) LEE, Sangkyu, Université McGill (Superviseur: Issam El Naqa) Assessment of different machine learning techniques for multivariate radiation pneumonitis modeling (17) LEGENDRE, Félix, IRCM (Superviseur: Éric Lécuyer) Defining a novel mechanism of mRNA localization to centrosomes in Drosophila (18) MOUJABER, Ossama, Université McGill (Superviseur: Ursula Stochaj) Biomarkers for the Aging of Human Mesenchymal Stem Cells (19) PHENIX, Hilary, Université d’Ottawa (Superviseur: Mads Kaern) Identifability and Interence of Pathway Topology by Epistasis Analysis (20) ROCHETTE, Samuel, Université Laval (Superviseur: Christian R. Landry) “Pin” pointing the dynamic of protein interaction networks (PINs) (21) SALEH, Sadiq M., Université McGill (Superviseurs: Morag Park & Michael Hallett) Mouse Models Of Breast Cancer Identify Oncogene-Specific Stroma Associated With Breast Cancer Molecular Subtypes (22) TAMBUTET, Guillaume, IRCM (Superviseur: Yvan Guindon) Second Generation of Nucleoside Analogues Targeting Solid Tumor (23) ZHANG, Olivia, IRCM (Superviseurs: Éric Lécuyer & Jérôme Waldispühl) Define structured, unstructures and disordered regions in coding RNA sequences (24) ZHOU, Gina, Université McGill (Superviseur : David Juncker) Cost-effective multiplexed immunoassays with fepto-molar sensitivity using silver amplification and a desktop scanner 4