3rd International IMBG Meeting on Metals in Health and Environment

3rd International IMBG Meeting on Metals in Health and
Environment
Autrans
du 22 au 24 septembre 2008
Monday 22th. - Morning session
8 :30 - 9 :00 Stéphane Ménage
Welcome
Chair:
9:00 - 9:45 Bibudhendra Sarkar (The Hospital for Sick Children,
Toronto, Canada)
Genetic Defects of Copper Transport: Wilson and Menkes
diseases”
9:45 - 10:15 Murielle Bost (Centre Maladie Rare, Bron, France)
Wilson disease, a copper disorder: an update
Coffee break
10:45 - 11:15 Michel Seve (Centre d'Innovation en Biologie, Grenoble,
France)
Mammalian Zinc transporters: With a special focus on Zinc
transporter 8 (SLC30A8) and diabetes: a promising new
diagnostic and therapeutic target
11:15 - 11:45 Ulrich Schweizer (Neuroscience Research Center, Berlin,
Germany)
How does selenium enter the brain and what does it do there?
11:45 - 12:15 Isabelle Michaud-Soret (Lab Chimie et Biologie des
Métaux, Grenoble)
Inhibition of the global metalloregulator Fur (ferric uptake
regulator) with anti-FUR peptide aptamers.

Monday 22th. - Afternoon session
Chair:
14:15 - 15:00 Alain Favier (University of Grenoble, CEA, INAC, SCIB-
LAN)
Carcinogenic effect of metals is related not only to but their
induction of DNA damages but also to their inhibition of
DNA repair.
15:00 - 15:30 Peggy L. Carver (University of Michigan, Ann Arbor, MI,
USA)
Plasma Concentrations of Trace Metal Ions and their
Correlation with Infection in Patients Undergoing Long-Term
Home Total Parenteral Nutrition (TPN).
15:30 - 16:00 B. Gyurcsik (University of Szeged, Hungary)
Chimeric metallonucleases for gene theraphy.
Coffee Break
16:30 - 17:00 Joël Poupon
17:00 - 17:30 Josiane Arnaud (CHU de Grenoble, Pôle de Biologie)
Are plasma copper, zinc and selenium concentrations
modified in Metabolic Syndrome? The Immidiet Project
POSTER SESSION (à 19:30)

Tuesday 23th - Morning session
Chair:
8:30 - 9:15 Peter Sadler (Department of Chemistry, University of Warwick,
UK)
Design of therapeutic metal complexes
9:15 - 9:45 Éva J. Tóth (Centre de Biophysique Moléculaire, Orléans
France)
Smart contrast agents in Magnetic Resonance Imaging:
detecting calcium fluctuations and enzymatic activity.
9:45 - 10:15 Pascale Delangle (CEA Grenoble)
Gd3+ complexes derived from natural molecules: coordination
and water proton relaxation properties
Coffee break
10:45 - 11:15 Lukeš, I (Universita Karlova, Prague, Czech Republic)
Gd(III) Based Contrast Agents for MRI: Molecular Volume
vs. Efficiency.
11:15 - 11:45 Peter Faller (Lab. de Chimie de Coordination du CNRS,
Toulouse, France)
Metals in Alzheimer’s Disease: Bioinorganic Chemistry of
Amyloid-β
11:45 - 12:15 Daniella Valensin (University of Siena, Italy)
Zn2+ and Cu2+ Interactions with Rat and Human βAmyloid
(1-28) peptides in H2O/SDS Solutions by NMR and CD
spectroscopy.

Tuesday 23th - Afternoon session
Chair:
14:15 - 15:00 Silvio Aime (Det. of Chem. & Mol. Imaging Center Univ. of
Torino, Italy)
Metal containing Nano-sized Systems for MR-Molecular
Imaging Applications
15:00 - 15:30 Tamim Chalati (Institut Lavoisier, Université de Versailles,
France)
Nanoparticles of Porous Iron Carboxylates as New Drug
Carriers
15:30 - 16:00 Marion Giraud (Institut de Nanosciences et Cryogénie,
CEA-Grenoble)
Tuning the properties of lanthanides probes through ligand
design.
Coffee break
16:30 - 17:00 Vincent Pecoraro (University of Michigan, Ann Arbor, MI,
USA)
De Novo Design of Heterochromic and Diastereomeric
Metalloproteins.
17:00 - 17:30 Gérard Jaouen (Ecole Nationale Supérieure de Chimie de
Paris)
Activation of polyphenols via an intramolecular
organometallic "antenna": biomedical applications.
POSTER SESSION (à 7:00)

Wednesday 24th
Chair:
8:30 - 9:15 Carlo Barbante (Dpt. of Environmental Sciences, Univ. of
Venice, Italy)
The History of Heavy Metal Pollution Revealed by Polar and
Alpine Ice.
9:15 - 9:45 Isabelle Schalk (University Louis Pasteur, Strasbourg,
France)
The metal specificities of the Pseudomonas aeruginosa
siderophore-iron uptake pathways: tools for bioaugmentation-
assisted phytoextraction
9:45 - 10:15 Michel Meyer (Institut de Chimie Moléculaire, Dijon,
France)
Silica-gel-bound macrocycles: A molecular approach to
remove lead from drinking water.
Coffee break
10:45 - 11:15 Kirstin Adriaensen (Hasselt Univ., Environmental Biology
Group, Belgium)
Mechanisms of metal sequestration in the metal tolerant
ectomycorrhizal fungus Suillus sp.
11:15 - 11:45 Jacques Covès (Institut de Biologie Structurale, Grenoble)
CopH and CzcE, two novel periplasmic proteins from
Cupriavidus metallidurans CH34 with unusual modes of
copper binding.
11:45 - 12:15 Sylvain Bohic (Institut des Neurosciences, Grenoble)
Synchrotron based spectro-microscopy for cell biology.