A “GENIUS” Approach for Breast Cancer Prognostication Benjamin Haibe-Kains

A “GENIUS” Approach for Breast Cancer
Prognostication
Benjamin Haibe-Kains1,2
1Functional Genomics Unit, Institut Jules Bordet
2Machine Learning Group, Universit´e Libre de Bruxelles
Benjamin Haibe-Kains (ULB) Talk at Karolinska Institute May 18, 2009 1 / 83

Research Groups
Functional Genomics Unit - Jules Bordet Institute
Head: Prof. Christos Sotiriou.
8 researchers (1 prof, 5 postDocs, 2 PhD students), 5 technicians.
Research topics : Genomic analyses, clinical studies and translational
research.
Website :
http://www.bordet.be/en/services/medical/array/practical.htm.
National scientific collaborations : ULB, Erasme, ULg, Gembloux
International scientific collaborations : Genome Institute of Singapore,
John Radcliffe Hospital, Karolinska Institute and Hospital, MD
Anderson Cancer Center, Netherlands Cancer Institute, Swiss Institute
of Bioinformatics, NCI/NIH, Gustave-Roussy Institute, IDDI.
Benjamin Haibe-Kains (ULB) Talk at Karolinska Institute May 18, 2009 2 / 83

Research Groups
Machine Learning Group - Universit´e Libre de Bruxelles
Head: Prof. Gianluca Bontempi.
10 researchers (2 prof, 4 postDoc, 4 PhD students), 4 graduate
students.
Research topics : Bioinformatics, Classification, Regression, Time
series prediction, Sensor networks.
Website : http://www.ulb.ac.be/di/mlg.
Scientific collaborations inside ULB : IRIDIA (Sciences Appliqu´ees),
Physiologie Molculaire de la Cellule (IBMM), Conformation des
Macromolcules Biologiques et Bioinformatique (IBMM), CENOLI
(Sciences), Functional Genomics Unit (Institut Jules Bordet), Service
d’Anesthesie (Erasme).
Scientific collaborations outside ULB : UCL Machine Learning Group
(B), Politecnico di Milano (I), Universit´a del Sannio (I), George
Mason University (US).
Benjamin Haibe-Kains (ULB) Talk at Karolinska Institute May 18, 2009 3 / 83

Outline
1Introduction
IBreast Cancer
ITraditional Approach for Prognostication
IGene Expression Profiling Approach for Prognostication
2Global Prognostic Gene Signatures
3Breast Cancer Molecular Subtypes
4Local Prognostic Gene Signatures
5Conclusions
Benjamin Haibe-Kains (ULB) Talk at Karolinska Institute May 18, 2009 4 / 83

Introduction
Benjamin Haibe-Kains (ULB) Talk at Karolinska Institute May 18, 2009 5 / 83