Molecular subtypes identification to refine breast cancer prognosis Benjamin Haibe-Kains

Molecular subtypes identification to refine breast cancer
prognosis
Benjamin Haibe-Kains1,2
1Functional Genomics Unit, Institut Jules Bordet
2Machine Learning Group, Universit´e Libre de Bruxelles
October 16, 2008
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Research Groups
Machine Learning Group (Gianluca Bontempi)
10 researchers (2 Profs, 1 postDoc, 7 PhD students), 2 graduate
students).
Research topics : Bioinformatics, Classification, Regression, Time
series prediction, Sensor networks.
Website : http://www.ulb.ac.be/di/mlg.
Scientific collaborations in ULB : IRIDIA (Sciences Appliqu´ees),
Physiologie Molculaire de la Cellule (IBMM), Conformation des
Macromolcules Biologiques et Bioinformatique (IBMM), CENOLI
(Sciences), Functional Genomics Unit (Institut Jules Bordet), Service
d’Anesthesie (Erasme).
Scientific collaborations outside ULB : UCL Machine Learning Group
(B), Politecnico di Milano (I), Universit´a del Sannio (I), George
Mason University (US).
The MLG is part to the ”Groupe de Contact FNRS” on Machine
Learning and to CINBIOS: http://babylone.ulb.ac.be/Joomla/.
Benjamin Haibe-Kains (ULB) Visit to IGC October 16, 2008 2 / 76
Research Groups
Functional Genomics Unit (Christos Sotiriou)
9 researchers (1 Prof, 5 postDocs, 3 PhD students), 5 technicians.
Research topics : Genomic analyses, clinical studies and translational
research.
Website :
http://www.bordet.be/en/services/medical/array/practical.htm.
National scientific collaborations : ULB, Erasme, ULg, Gembloux,
IDDI.
International scientific collaborations : Genome Institute of Singapore,
John Radcliffe Hospital, Karolinska Institute and Hospital, MD
Anderson Cancer Center, Netherlands Cancer Institute, Swiss Institute
for Experimental Cancer Research, NCI/NIH, Gustave-Roussy
Institute.
Benjamin Haibe-Kains (ULB) Visit to IGC October 16, 2008 3 / 76
Summary
Introduction
IBreast Cancer
IPrognosis
IGene Expression Profiling
Breast Cancer Molecular Subtypes
Prognostic Gene Signatures
Subtypes and Prognosis
IGENIUS
Conclusion
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Part I
Introduction
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Molecular subtypes identification to refine breast cancer prognosis Benjamin Haibe-Kains

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