Bulletin électronique de veille Cancer Environnement N°16 du 02/04/2015
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Bulletin électronique de veille Cancer Environnement N°16 du 02/04/2015 Ce bulletin de veille signale mensuellement une sélection de documents identifiés dans le cadre de la veille cancer environnement. La méthodologie mise en œuvre est présentée dans la fiche du site cancer environnement : http://www.cancer-environnement.fr/334-Veille-scientifique.ce.aspx Publications récentes Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study. Exposition professionnelle aux perturbateurs endocriniens et risque de lymphome dans une étude européenne multicentrique. Costas L et al., Br J Cancer. 2015 Mar Background: Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against lymphoma. Methods :We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study.Results:Over 30 years of exposure to EDCs compared to no exposure was associated with a 24% increased risk of mature Bcell neoplasms (P-trend=0.02). Associations were observed among men, but not women.Conclusions:Prolonged occupational exposure to endocrine disruptors seems to be moderately associated with some lymphoma subtypes Residential Exposure to Estrogen Disrupting Hazardous Air Pollutants and Breast Cancer Risk: The California Teachers Study. Exposition résidentielle aux perturbateurs estrogéniques dangereux émis par atmosphériques et risque de cancer du sein : Etude auprès d’enseignants Californiens Liu R et al., Epidemiology. 2015 Mar les polluants BACKGROUND: Some studies show increased breast cancer risk from exposure to xenoestrogens, but few have explored exposures via ambient air, which could impact large populations. OBJECTIVES: This study explored the association between breast cancer risk and residential exposures to ambient estrogen disruptors among participants in a large cohort study, the California Teachers Study. 1 METHODS: Participants consisted of 112,379 women free of breast cancer and living at a California address in 1995/1996. Eleven hazardous air pollutants from the US Environmental Protection Agency 2002 list were identified as estrogen disruptors based on published endocrine disrupting chemical lists and literature review. Census-tract estrogen disruptor air concentrations modeled by the US Environmental Protection Agency in 2002 were assigned to participants' baseline addresses. Cox proportional hazards models were used to estimate hazard ratios associated with exposure to each estrogen disruptor and a summary measure of nine estrogenic hazardous air pollutants among all participants and selected subgroups, adjusting for age, race/birthplace, socioeconomic status, and known breast cancer risk factors. RESULTS: Five thousand three hundred sixty-one invasive breast cancer cases were identified between 1995 and 2010. No associations were found between residential exposure to ambient estrogen disruptors and overall breast cancer risk or hormone receptor-positive breast cancer risk, nor among targeted subgroups of participants (pre-/peri-menopausal women, post-menopausal women, never-smokers, non-movers, and never-smoking nonmovers). However, elevated risks for hormone receptor-negative tumors were observed for higher exposure to cadmium compounds and possibly inorganic arsenic among never-smoking non-movers. CONCLUSION: Long-term, low-dose exposure to ambient cadmium compounds or possibly inorganic arsenic may be a risk factor for breast cancer. Estimated dietary dioxin exposure and breast cancer risk among women from the French E3N prospective cohort Exposition à la dioxine alimentaire estimée et risque de cancer du sein parmi les femmes de la cohorte prospective française E3N Danjou A et al., Breast Cancer Research 2015 Mar Dioxins are environmental and persistent pollutants mostly emitted from combustion facilities (e.g. waste incinerators, metal and cement industries). Known to be endocrine disrupting chemicals, dioxins are suspected to increase breast cancer (BC) risk. Although diet is considered the primary source of dioxin exposure, no previous study has been published on dietary dioxin exposure in relation to BC risk. We aimed to assess dietary dioxin exposure among women from the E3N cohort and estimate BC risk associated with this exposure. Methods : The study included 63,830 women from the E3N cohort who completed a diet history questionnaire (DHQ) in 1993 and were followed until 2008. Dietary dioxin exposure was estimated by combining consumption data from the E3N DHQ and food dioxin contamination data from a French national monitoring program. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated by Cox models adjusted for BC risk factors. Results : Mean dietary dioxin exposure was estimated at 1.3 ± 0.4 pg/kg body weight (BW)/day. A 0.4 pg/kg BW/d increase in dioxin intake was not associated with overall BC risk (HR = 1.00; 95% CI: 0.96, 1.05). A significant decrease in risk of estrogen receptor negative (ER-)/progesterone receptor negative (PR-) tumors was observed among post-menopausal women in the upper quartile of estimated dioxin intake (HR for Q4 vs. Q1: 0.65; 95% CI: 0.45, 0.96; P for trend across quartiles = 0.0463). Conclusions : Overall, no association between estimated dietary dioxin exposure and BC risk was found among E3N women. Further studies should include both dietary and environmental exposures to determine whether low-dose dioxin exposure is associated with BC risk. 2 Anthropometric factors and endometrial cancer risk: A systematic review and dose-response meta-analysis of prospective studies. Facteurs anthropométriques et risque de cancer de l'endomètre : une revue systématique et une métaanalyse dose-réponse des études prospectives. Aune D et al., Ann Oncol. 2015 Mar Greater body mass index has been convincingly related to increased endometrial cancer risk, however, whether adiposity earlier in life or abdominal fatness, is an independent risk factor and whether weight gain or greater height increases the risk is not clear. METHODS: As part of the Continuous Update Project of the World Cancer Research Fund International we conducted a systematic review and meta-analysis of prospective studies of the association between anthropometric measures and endometrial cancer risk and searched PubMed and several other databases up to February 2015. Summary relative risks were calculated using a random effects model. RESULTS: Thirty prospective studies of BMI and endometrial cancer risk with 22320 cases among 6445402 participants were included. The summary relative risk (RR) for a 5 unit increment was 1.54 (95% CI: 1.47-1.61, I2=81%). Although the test for nonlinearity was significant, pnonlinearity<0.0001, and the curve was steeper within the overweight and obese BMI ranges, there was evidence of increased risk even within the high normal BMI range. The summary RR was 1.45 (95% CI: 1.28-1.64, I2=76%) per 5 BMI units for BMI in young adulthood, 1.18 (95% CI: 1.14-1.23, I2=67%) per 5 kg increase of weight, and 1.16 (95% CI: 1.12-1.20, I2=51%) per 5 kg of weight gained between young adulthood and study baseline, 1.27 (95% CI: 1.17-1.39, I2=71%) per 10 cm increase in waist circumference, 1.21 (95% CI: 1.13-1.29, I2=0%) per 0.1 unit increment in waist-to-hip ratio and 1.30 (95% CI: 1.19-1.41, I2=0%) per 10 cm increase in hips circumference. The summary RR was 1.15 (95% CI: 1.09-1.22, I2=61%) for a 10 cm increase in height. CONCLUSIONS: All measures of adiposity were associated with increased risk of endometrial cancer, and in addition increasing height was associated with increased risk. 3 Actualités et lettres d’information des acteurs Santé Environnement Région Rhône-Alpes National Agence Régionale de Santé Rhône-Alpes Agence nationale de sécurité sanitaire, de l’alimentation, de l’environnement et du travail Air Rhône-Alpes Bulletin de veille bibliographique Nota Bene Cancer de l’Institut National du Cancer (INCa) Lettre d’information de l’INCa Espace Régional de Santé Publique RhôneAlpes Institut national de recherche en sciences et technologies pour l’environnement et l’agriculture Fédération Rhône-Alpes de Protection de la Nature Lettre d’information de l’Institut National de Recherche et de Sécurité pour la prévention des accidents du travail et des maladies professionnelles Institut de Recherche en Santé Publique Lettre d’information “Ademe et vous” Lettre Santé-Environnement Rhône-Alpes de l’ORS Rhône-Alpes Lettre d’information de l’IReSP La lettre de la Société Française de Santé Environnement Société Française de Santé Publique Bulletin Flash e-mail SFSP Société Française de Médecine du Travail Nos partenaires Avec soutien de : Pour tout abonnement/désabonnement à cet e-bulletin ou pour nous faire part d'informations à diffuser dans les prochains numéros, n’hésitez pas à nous écrire à l'adresse suivante : [email protected] Afin de respecter la législation sur la propriété intellectuelle, le bulletin de veille électronique renvoie l’internaute à la source d’origine de chacune des ressources répertoriées. Il propose systématiquement des liens vers d’autres sites qui ne relèvent pas de son autorité. Il est à noter qu’il n’est pas responsable du contenu de ces sites, des liens qui y sont suggérés et des changements ou mises à jour qu’ils subissent. « La relecture et sélection des publications de ce bulletin électronique est réalisée par des membres du comité éditorial du portail cancer-environnement.fr avec la participation des professionnels de santé du Centre Léon Bérard et ses partenaires, sur la base de leur pertinence dans le champ ‘cancer, environnement et nutrition’. Dans la mesure où le contenu des sources et des informations recensées dans ce e-bulletin n’engagent que leurs auteurs, il appartient au lecteur d’en évaluer la qualité. » E-Bulletin réalisé par le Comité Editorial du portail http://www.cancer-environnement.fr/48-Qui-sommes-nous.ce.aspx 4
