Bulletin électronique de veille Cancer Environnement N°16 du 02/04/2015

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Bulletin électronique de veille Cancer Environnement
N°16 du 02/04/2015
Ce bulletin de veille signale mensuellement une sélection de documents identifiés dans le cadre de la
veille cancer environnement. La méthodologie mise en œuvre est présentée dans la fiche du site cancer
environnement : http://www.cancer-environnement.fr/334-Veille-scientifique.ce.aspx
Publications récentes
Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European
study.
Exposition professionnelle aux perturbateurs endocriniens et risque de lymphome dans une étude
européenne multicentrique.
Costas L et al., Br J Cancer. 2015 Mar
Background:
Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against
lymphoma. Methods :We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among
2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study.Results:Over
30 years of exposure to EDCs compared to no exposure was associated with a 24% increased risk of mature B-
cell neoplasms (P-trend=0.02). Associations were observed among men, but not women.Conclusions:Prolonged
occupational exposure to endocrine disruptors seems to be moderately associated with some lymphoma subtypes
Residential Exposure to Estrogen Disrupting Hazardous Air Pollutants and Breast Cancer Risk:
The California Teachers Study.
Exposition résidentielle aux perturbateurs estrogéniques dangereux émis par les polluants
atmosphériques et risque de cancer du sein : Etude auprès d’enseignants Californiens
Liu R et al., Epidemiology. 2015 Mar
BACKGROUND:
Some studies show increased breast cancer risk from exposure to xenoestrogens, but few have explored
exposures via ambient air, which could impact large populations.
OBJECTIVES:
This study explored the association between breast cancer risk and residential exposures to ambient estrogen
disruptors among participants in a large cohort study, the California Teachers Study.

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METHODS:
Participants consisted of 112,379 women free of breast cancer and living at a California address in 1995/1996.
Eleven hazardous air pollutants from the US Environmental Protection Agency 2002 list were identified as
estrogen disruptors based on published endocrine disrupting chemical lists and literature review. Census-tract
estrogen disruptor air concentrations modeled by the US Environmental Protection Agency in 2002 were
assigned to participants' baseline addresses. Cox proportional hazards models were used to estimate hazard ratios
associated with exposure to each estrogen disruptor and a summary measure of nine estrogenic hazardous air
pollutants among all participants and selected subgroups, adjusting for age, race/birthplace, socioeconomic
status, and known breast cancer risk factors.
RESULTS: Five thousand three hundred sixty-one invasive breast cancer cases were identified between 1995
and 2010. No associations were found between residential exposure to ambient estrogen disruptors and overall
breast cancer risk or hormone receptor-positive breast cancer risk, nor among targeted subgroups of participants
(pre-/peri-menopausal women, post-menopausal women, never-smokers, non-movers, and never-smoking non-
movers). However, elevated risks for hormone receptor-negative tumors were observed for higher exposure to
cadmium compounds and possibly inorganic arsenic among never-smoking non-movers.
CONCLUSION: Long-term, low-dose exposure to ambient cadmium compounds or possibly inorganic arsenic
may be a risk factor for breast cancer.
Estimated dietary dioxin exposure and breast cancer risk among women from the French E3N
prospective cohort
Exposition à la dioxine alimentaire estimée et risque de cancer du sein parmi les femmes de la cohorte
prospective française E3N
Danjou A et al., Breast Cancer Research 2015 Mar
Dioxins are environmental and persistent pollutants mostly emitted from combustion facilities (e.g. waste
incinerators, metal and cement industries). Known to be endocrine disrupting chemicals, dioxins are suspected to
increase breast cancer (BC) risk. Although diet is considered the primary source of dioxin exposure, no previous
study has been published on dietary dioxin exposure in relation to BC risk. We aimed to assess dietary dioxin
exposure among women from the E3N cohort and estimate BC risk associated with this exposure.
Methods :
The study included 63,830 women from the E3N cohort who completed a diet history questionnaire (DHQ) in
1993 and were followed until 2008. Dietary dioxin exposure was estimated by combining consumption data
from the E3N DHQ and food dioxin contamination data from a French national monitoring program. Hazard
ratios (HR) and 95% confidence intervals (CI) were estimated by Cox models adjusted for BC risk factors.
Results :
Mean dietary dioxin exposure was estimated at 1.3 ± 0.4 pg/kg body weight (BW)/day. A 0.4 pg/kg BW/d
increase in dioxin intake was not associated with overall BC risk (HR = 1.00; 95% CI: 0.96, 1.05). A significant
decrease in risk of estrogen receptor negative (ER-)/progesterone receptor negative (PR-) tumors was observed
among post-menopausal women in the upper quartile of estimated dioxin intake (HR for Q4 vs. Q1: 0.65; 95%
CI: 0.45, 0.96; P for trend across quartiles = 0.0463).
Conclusions :
Overall, no association between estimated dietary dioxin exposure and BC risk was found among E3N women.
Further studies should include both dietary and environmental exposures to determine whether low-dose dioxin
exposure is associated with BC risk.

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Anthropometric factors and endometrial cancer risk: A systematic review and dose-response
meta-analysis of prospective studies.
Facteurs anthropométriques et risque de cancer de l'endomètre : une revue systématique et une méta-
analyse dose-réponse des études prospectives.
Aune D et al., Ann Oncol. 2015 Mar
Greater body mass index has been convincingly related to increased endometrial cancer risk, however, whether
adiposity earlier in life or abdominal fatness, is an independent risk factor and whether weight gain or greater
height increases the risk is not clear.
METHODS: As part of the Continuous Update Project of the World Cancer Research Fund International we
conducted a systematic review and meta-analysis of prospective studies of the association between
anthropometric measures and endometrial cancer risk and searched PubMed and several other databases up to
February 2015. Summary relative risks were calculated using a random effects model.
RESULTS: Thirty prospective studies of BMI and endometrial cancer risk with 22320 cases among 6445402
participants were included. The summary relative risk (RR) for a 5 unit increment was 1.54 (95% CI: 1.47-1.61,
I2=81%). Although the test for nonlinearity was significant, pnonlinearity<0.0001, and the curve was steeper
within the overweight and obese BMI ranges, there was evidence of increased risk even within the high normal
BMI range. The summary RR was 1.45 (95% CI: 1.28-1.64, I2=76%) per 5 BMI units for BMI in young
adulthood, 1.18 (95% CI: 1.14-1.23, I2=67%) per 5 kg increase of weight, and 1.16 (95% CI: 1.12-1.20,
I2=51%) per 5 kg of weight gained between young adulthood and study baseline, 1.27 (95% CI: 1.17-1.39,
I2=71%) per 10 cm increase in waist circumference, 1.21 (95% CI: 1.13-1.29, I2=0%) per 0.1 unit increment in
waist-to-hip ratio and 1.30 (95% CI: 1.19-1.41, I2=0%) per 10 cm increase in hips circumference. The summary
RR was 1.15 (95% CI: 1.09-1.22, I2=61%) for a 10 cm increase in height.
CONCLUSIONS: All measures of adiposity were associated with increased risk of endometrial cancer, and in
addition increasing height was associated with increased risk.

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Actualités et lettres d’information des acteurs Santé Environnement
Région Rhône-Alpes
National
Agence Régionale de Santé Rhône-Alpes
Agence nationale de sécurité sanitaire, de
l’alimentation, de l’environnement et du
travail
Air Rhône-Alpes
Bulletin de veille bibliographique Nota Bene
Cancer de l’Institut National du Cancer
(INCa)
Lettre d’information de l’INCa
Espace Régional de Santé Publique Rhône-
Alpes
Institut national de recherche en sciences et
technologies pour l’environnement et
l’agriculture
Fédération Rhône-Alpes de Protection de la
Nature
Lettre d’information de l’Institut National de
Recherche et de Sécurité pour la prévention
des accidents du travail et des maladies
professionnelles
Institut de Recherche en Santé Publique
Lettre d’information “Ademe et vous”
Lettre Santé-Environnement Rhône-Alpes de
l’ORS Rhône-Alpes
Lettre d’information de l’IReSP
La lettre de la Société Française de Santé
Environnement
Société Française de Santé Publique Bulletin
Flash e-mail SFSP
Société Française de Médecine du Travail
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