la toxoplasmose

Para6-Toxoplasmose
1
!
LA#TOXOPLASMOSE#
!
!
!
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I. Agent!pathogène,!cycle!de!développement!
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Cycle!(p15)!:!
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W-!F!#!20(!$/#)'&*0!&++20&'#&$(!>2+*$#-(!@\)B!('!)(--2-#&$(!@M>GBD!

Para6-Toxoplasmose
2
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Bradizoïtes!;! &-%! <*0'! %(! $('$*2<($! 1#0%! 1(%! ]F%'(%! %&'2/%! 1#0%! 1(%! )(--2-(%! ,/$(00(%! @<&<#0'!
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!
!
II. Epidémiologie!
!
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L*$%!12!`WV\!;!-#!1&+&02'&*0!1(%!EVT!(0'$#k0(!-(!$/<(&-!1(%!]F%'(%D!

Para6-Toxoplasmose
3
III. La!maladie!
!
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!
!
!
!
!
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!

Para6-Toxoplasmose
4
!
IV. Diagnostic!biologique!
!
L(!1&#50*%'&)!1&$()'!(%'!1&77&)&-(!!,*2$!)(!,#$#%&'(A!1o!S!%#!,$/%(0)(!'&%%2-#&$(D!b0!,$#'&82(!#&0%&!
,$/7/$#4-(+(0'!20!1&#50*%'&)!&01&$()'A!diagnostic!sérologique.!V#0%!)($'#&0%!)#%!,$/)&%A!*0!7#&'!
20! 1&#50*%'&)! 1&$()'A! 0*'#++(0'! -*$%82(! -#! %/$*-*5&(! 0(! 1*00(! #2)20! &01&)(! @%F%'.+(!
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*+4&-&)#-A!('!)>(?!-(%!,($%*00(%!,-2%!d5/(%!1#0%!-(!LEYA!-#!+*(--(!*%%(2%(!('!-(!%#05p!
9 ^$*''&%A!#,,*%&'&*0%!)*-*$/(%!#2!3mm!
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9 E2-'2$(%!)(--2-#&$(%!@7&4$*4-#%'(%A!-&50/(%!1(!+*0*)F'(%B!
9 q&*-*5&(! +*-/)2-#&$(!;! "EY!r! 5.0(! qG! 12! ,#$#%&'(! 2'&-(! 1#0%! -(! 1&#50*%'&)! #0'/0#'#-! *2!
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!C'!(87#&#*-0!0(3!(D(38)'3-=:0)0+3!%7'3-=:80!%#:7!,8%-(307!:+0!(87#2#+?07(-#+!,'+(!&0!2',70!,0!&'!
*7#((0((0!
!
Evolution!des!Ac!au!cours!du!temps!(voir!p.9!du!poly)!
E>(?!-=&01&<&12!&++20*)*+,/'(0'!;!
W53!1.%!-#!G.$(!%(+#&0(!#,$.%!-#!)*0'#+&0#'&*0A!+#:&+#-(!#,$.%!20!+*&%!('!1&%,#$&'&*0!#,$.%!T!S!
I!+*&%D!
\<()!-(%!'()>0&82(%!+*1($0(%!*0!'$*2<(!1(%!'#2:!$/%&12(-%!4(#2)*2,!,-2%!-*05'(+,%D!
W5m!;!j!S!GO!N$%!#,$.%!-#!)*0'#+&0#'&*0A!,-#'(#2!<($%!-(!Q(!+*&%!('!1&+&02'&*0!<($%!T9I+*&%!%#0%!
N#+#&%!1&%,#$#k'$(!@(0'$(!G_!('!R__!r!'*:*,-#%+*%(!#0)&(00(BD!
e0'$(!R__!('!R___!;!'*:*,-#%+*%(!/<*-2'&<(D!
G_!gWX+L!;!%(2&-!1(!1/'()'&*0D!
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E*++(!-(!'#2:!/<*-2(!1#0%!-(!'(+,%A!&-!7#2'!#2!+*&0%!1(2:!+(%2$(%!,*2$!%#<*&$!*s!*0!%(!'$*2<(D!
!
Nomenclature!
V(%)$&,'&*0!1(!-=#)'(!4&*-*5&82(D!
g'&-&%#'&*0!1(!Q!'()>0&82(%!('!Q!&%*'F,(%!@W5m!'&'$/(%!(0!gWBD!
L(!4&*-*5&%'(!1*&'!&0'($,$/'($!-(%!$/%2-'#'%D!
!
Législation!
e:#+(0!,$/02,'&#-!@*4-&5#'*&$(!1(,2&%!GHtjBD!
e:#+(0!,$/0#'#-!1(,2&%!GHjO@%&!%/$*-*5&(!0/5#'&<(!;!(:#+(0%!+(0%2(-%@GHHQBBD! ! !
`2$<(&--#0)(!1(%!'$#0%,-#0'#'&*0%!;!1/,&%'#5(!1*00(2$!$()(<(2$!1(!'*2%!-(%!'&%%2%!@GHHTBD!
uWJ!;!1/,&%'#5(!1(!'*:*,-#%+*%(!>#2'(+(0'!$()*++#01/D!
!
Techniques!
Y/#)'&7%!)*++($)&#-&%/%D!
L#4*$#'*&$(%!%,/)&#-&%/%!1#0%!-#!'*:*,-#%+*%(!(:&%'#0'%D!!
!
ED0F30(3!@-#4*!%,/)&#-&%/!20&82(+(0'B!
W-!7#2'!1(%!)2-'2$(%!1(!'*:*,-#%+(%D!
b0!</$&7&(!%&!-(!%/$2+!-F%(!-(!'*:*,-#%+(!@#<()!12!)*+,-/+(0'!>2+#&0!7$#&%B!
g'&-(!,*2$!-(!1*%#5(!1(%!W53!('!W5mD!
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G)):+#9&:#70(20+20!-+,-70230!@(0!,($'(!1(!<&'(%%(B!
W5m!('!W53!;!'(%'!1(!Y(+&05'*0!

Para6-Toxoplasmose
5
"*%%&4&-&'/!1(!7#2:!,*%&'&7%!12%!S!1(%!7#)'(2$%!$>2+#'*U1(%A!&0'($7/$(0)(!#<()!1=#2'$(%!W53!
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!
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V&$()'(!;!%2%,(0%&*0!1(!'*:*,-#%+(!7&:/(D!
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b0!'$#<#&--(!#<()!-(!Q!+($)#,'*/'>#0*-!@,*2$!-F%($!-(%!W53B!,*2$!1&77/$(0)&($!W53!('!W5\D!
W01&$()'(!;!2'&-&%#'&*0!1=(:'$#&'%!,$*'/&82(%!82&!%*0'!7&:/%D!
"(2'!['$(!$/#-&%($!#<()!*2!%#0%!'$#&'(+(0'!#2!Q9+($)#,'*/'>#0*--D!
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