L`infection par Papillomavirus évolution spontanée, prévention…

L’infection par Papillomavirus
évolution spontanée,
prévention…
Pr Ph Simon
ULB Hôpital Erasme
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W-Age Standardised Rate
(/100 000 women-years)
0 to 1.49 (2)
1.5 to 2.99 (10)
3.0 to 4.49 (8)
4.5 to 5.99 (9)
6.0 to 7.49 (8)
7.5 to 8.99 (3)
9.0 to 11.49 (2)
Cervical cancer mortality in Europe
Source:
Globocan 2000,
IARC
Map produced by M. Arbyn
66000 femmes par an
66000 femmes par an
29000 d
29000 dé éc cè ès s

*Rate per 100,000 population (all ages).
Cervical cancer
Ferlay J et al. Globocan 2002. IARC 2004.
Incidence mondiale
500,000 femmes par ans développent un
cancer du col

A remarkably strong association in
cancer epidemiology
Newborn HBV vaccination and liver cancer in Taiwan0.1
Adult HBV vaccination and liver cancer in Korea0.6
Smoking cessation (< 50 years) and lung cancer0.1
BASELINE REFERENCE
Cigarette smoking and lung cancer10
Hepatitis C virus and liver cancer in Italy20
Hepatitis B virus and liver cancer in Greece50
Hepatitis B virus and liver cancer in Taiwan100
HPV and cervical cancer in Bangkok
HPV 16 and cervical cancer in Costa Rica
HPV 18 and cervical adenocarcinoma in the Philippines> 500
RR
1
Bosch FX et al. J Clin Pathol 2002; 55: 244–65.
The virus

Odds ratio for cervical cancer
HPV 16
Odds Ratio
110 100 1000
Combined
Herrero, 2005
Hammouda, 2005
Asato, 2004
Munoz, 2003
Franceschi, 2003
Altekruse, 2003
Thomas, 2001
Sasagawa, 2001
Hwang, 1999
Ferrera, 1999
Odds ratio for cervical cancer
HPV 18
Odds Ratio
110 100 1000
Combined
Herrero, 2005
Hammouda, 2005
Asato, 2004
Munoz, 2003
Franceschi, 2003
Altekruse, 2003
Sasagawa, 2001
Hwang, 1999
Ferrera, 1999
Odds ratio for cervical cancer
HPV 45
Odds Ratio
110 100 1000
Combined
Herrero, 2005
Hammouda, 2005
Munoz, 2003
Franceschi, 2003
Sasagawa, 2001
Odds ratio for cervical cancer
HPV 33
Odds Ratio
110 100 1000
Combined
Herrero, 2005
Asato, 2004
Munoz, 2003
Ferrera, 1999
Odds ratio for cervical cancer
HPV 59
Odds Ratio
110 100 1000
Combined
Asato, 2004
Munoz, 2003
Franceschi, 2003
Odds ratio for cervical cancer
HPV 31
Odds Ratio
110 100 1000
Combined
Herrero, 2005
Asato, 2004
Munoz, 2003
Sasagawa, 2001
Ferrera, 1999
Odds ratio for cervical cancer
HPV 35
Odds Ratio
110 100 1000
Combined
Asato, 2004
Munoz, 2003
Odds ratio for cervical cancer
HPV 52
Odds Ratio
110 100 1000
Combined
Herrero, 2005
Asato, 2004
Munoz, 2003
Sasagawa, 2001
Hwang, 1999
Ferrera, 1999
Odds ratio for cervical cancer
HPV 58
Odds Ratio
110 100 1000
Combined
Herrero, 2005
Asato, 2004
Munoz, 2003
Franceschi, 2003
Sasagawa, 2001
Hwang, 1999
Ferrera, 1999