Sodium benzoate et MIT – Louis

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DESS$DE$COSMETOLOGIE$
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SODIUM$BENZOATE$ET$MIT$
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TABLE$DES$MATIERES$
Introduction$............................................................................................................................$5!
1.!Benzoate$de$sodium$et$MIT$..............................................................................................$6!
1.1.!Identité,$propriétés$physiques$et$chimiques$............................................................................$6!
1.2.!Utilisation$...............................................................................................................................$7!
1.3.!Ce$que$l’on$cherche$sur$le$web$................................................................................................$8!
1.4.!Ce$que$le$web$nous$explique$...................................................................................................$9!
2.!Réglementation$..............................................................................................................$11!
2.1.!Européenne$..........................................................................................................................$11!
2.2.!Canadienne$...........................................................................................................................$13!
3.!Mécanisme$d’action$........................................................................................................$15!
3.1.!Acide$benzoïque$/$sodium$benzoate,$historique$....................................................................$15!
3.2.!MIT$.......................................................................................................................................$16!
4.!Moyens$d’obtention$.......................................................................................................$17!
4.1.!Sources$naturels$de$l’acide$benzoïque$...................................................................................$17!
4.2.!Source$chimique$du$benzoate$de$sodium$..............................................................................$17!
4.3.!Synthèse$chimique$des$thiazolinones$....................................................................................$17!
5.!Caractérisation$...............................................................................................................$20!
5.1.!Identification$Acide$Benzoïque$[Directive$95/32/CE]$.............................................................$20$!
5.2.!Dosage$de$l'acide$benzoïque$.................................................................................................$22!
5.3.!MI/MCI$.................................................................................................................................$23!
6.!Toxicité,$évaluation$des$risques$......................................................................................$24!
6.1.!Benzoate$de$sodium$.............................................................................................................$24!
6.2.!MIT$.......................................................................................................................................$25!
6.3.!Génotoxicité$et$sodium$benzoate$..........................................................................................$26!
6.4.!Hypersensibilité$et$MIT$.........................................................................................................$30!
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7.!Substitution$....................................................................................................................$35!
Conclusion$.............................................................................................................................$36!
Bibliographie$.........................................................................................................................$37!
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TABLE$DES$FIGURES$
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• Figure!1!:!S-/:!59746-3/Q.:!C:!34!2479P-8/:!C:0!432--30!6:;TE3/Q.:!!UUUUUUUUUUUUUUUUUUUUU!!!V!
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• Figure!2!:!WE;7XY0:!C:0!/0-7X/4T-3/;-;:0!UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU!!<M!
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• Figure!3!:!&9427/-;0!B-0/7/G:0!4.!B472X!7:07!Z4!:7!6![!\O!2[\\O!C[\\\]UUUUUUUUUUUUUUUUUUUUU!!?^!
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• Figure!4!:!89427/-;!B-0/7/G:!4.!"*!0:.3!B48!B472X!7:07!!!UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU!!?^!
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• Figure!5!:!&9427/-;0!B-0/7/G:0!4.J!B472X!7:070!_!34!"A*>"*!:7!"*O!*WO!*0-7X/4T-3/;-;:!!!!UUUUUUU!!L<!
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LISTE$DES$TABLEAUX$
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• Tableau!1!:!/C:;7/79O!B8-B8/9790!BXE0/Q.:0!:7!2X/5/Q.:0UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU!!M!
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• Tableau!2!:!+;78/:0!L^!4;C!`V!-F!';;:J!S!7-!&:P.347/-;!Z+A]!$-!<??L>?==^!-;!2-05:7/2!!!!
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• Tableau!3!:!)/07-8/Q.:O!.04P:!2-.84;7!:7!2-;2:;7847/-;!CR.7/3/047/-;!C.!"*!!UUUUUUUUUUUUUUU!<<!
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• Tableau!4!:!+FF:7!C.!B)!0.8!34!C/00-2/47/-;!C:!3R42/C:!6:;T-bQ.:!!UUUUUUUUUUUUUUUUUUUUUUUU!<@!
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• Tableau!5!:!Skin!irritaiton!and!sensitization!studies___________________________________!24!
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• Tableau!6!:!'6:8847/-;0!2X8-5-0-5/Q.:0!0.8!C:0!2.37.8:0!C:0!3E5BX-2E7:0!X.54/;0!!!!!!!!!!!!
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• Tableau!7!:!c89Q.:;2:!CR92X4;P:!C:!2X8-547/C:0!0d.80!C4;0!C:0!2.37.8:0!C:!3E5BX-2E7:0!
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• Tableau!8!:!"/28-;-E4.J!C4;0!3:0!2.37.8:0!X.54/;:0!C:!3E5BX-2E7:0!784/79:0!4.!6:;T-47:!!!!!!!!!!!
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• Tableau!10!:!'.P5:;747/-;!C.!74.J!C:!0:;0/6/3/047/-;!:7!74.J!C:!0:;0/6/3/047/-;!_!34!"*!!!!!!!!!!!!!!!
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