!"#$%&'()*+&,-."/"01'()#(2'%.$'(+&,-."341/1-1$'(5(67(8#1%(9:6;(5(<-$1=>(?$-%@'(
!"#$%&'(')'*$+,'-./0' '
/'
!
Quelle!stratégie!pour!éliminer!l’antigène!HBs!?!
Professeur!Didier!SAMUEL'''
12342'456+7"&'2"$&'89:$;;%<'=%,79%'4>6"7:38+&+"+9%<'?+&&%@$+A<'B9",C%'
D,+E'2"9+;3!$F<'DGH3!'IJK<'?+&&%@$+A<'B3L0J..<'B9",C%'
M,;%9#<'D,+7>'IJK<'?+&&%@$+A<'B3L0J..<'B9",C%'
'
'
NO",7+PQ,%'48;'%;7'&O%,E%&:66%'P&RC:;R&>%'69:7>+S$%'F$'E+9+:,'F%'&OT>6"7+7%'8U'V,'C:,;+FQ9%'
S$%'&"'P$>9+;:,'F%'&OT>6"7+7%'8'%;7'";;:C+>%'W'&"'F+;6"9+7+:,'F%'&O",7+PQ,%'48;'%7'W'&O"66"9+7+:,'
F%' &O",7+C:96;' ",7+' 48;U' X,' %AA%7' T"Y+7$%&&%#%,7' F",;' C%77%' ;+7$"7+:,' &O1(Z' F$' E+9$;' F%'
&OT>6"7+7%'8'%;7'+,F>7%C7"Y&%'F",;'&%';>9$#'%7'C%77%';+7$"7+:,'%;7'C:,;+F>9>%'C:##%'&%'Y$7'
69+,C+6"&'F$'79"+7%#%,7'F%'&OT>6"7+7%'CT9:,+S$%'8U'N"'C:,;7"7"7+:,'%;7'S$O+&';O"P+7'C%6%,F",7<'
;:+7';6:,7",>#%,7<';:+7';:$;'79"+7%#%,7<'FO$,'>E>,%#%,7'9"9%U'N%;'7T>9"6+%;' ",7+'E+9"&%;'8'
;:,7'C"6"Y&%;'%;;%,7+%&&%#%,7'F%'C:,795&%9'&"'9>6&+C"7+:,'E+9"&%'8<'F%'&"'9%,F9%'+,F>7%C7"Y&%'
#"+;',%';:,7'6";'C"6"Y&%;'F",;'&"'6&$6"97'F%;'C";'FO>&+#+,%9'&O",7+PQ,%'48;'%7'FO:Y7%,+9'$,%'
;>9:C:,E%9;+:,'",7+PQ,%'48;'['1,7+C:96;'",7+'48;U'
'
Quelle!est!l’histoire!naturelle!de!l’hépatite!chronique!B!?!
V,' %;7+#%' S$O%,' C";' FOT>6"7+7%' CT9:,+S$%' 8<' ;%$&;' /.' \' F%;' 6"7+%,7;' E:,7' >&+#+,%9'
;6:,7",>#%,7'&O",7+PQ,%'48;'"E%C';>9:C:,E%9;+:,'",7+PQ,%'48;'['",7+C:96;'",7+'48;'"69Q;'
-.3].'",;'FO>E:&$7+:,U'
=T%^'&%;'6"7+%,7;'",7+PQ,%'48%'6:;+7+A<'&%'7"$_'FO",7+PQ,%'48;';%#Y&%'Y"+;;%9'W'&"'6T";%'F%'
9>6:,;%'+##$,%'6"9'9"66:97'W'&"'6T";%'F%'7:&>9",C%'#"+;';%#Y&%'6%$'69>F+C7+A'F$'F%E%,+9'
F%'&O",7+PQ,%'48;U'
!"#$%&'()*+&,-."/"01'()#(2'%.$'(+&,-."341/1-1$'(5(67(8#1%(9:6;(5(<-$1=>(?$-%@'(
!"#$%&'(')'*$+,'-./0' '
-'
=T%^' &%;' 6"7+%,7;' S$+' :,7' $,%' T>6"7+7%' CT9:,+S$%' 8<' ",7+PQ,%' 48%' ,>P"7+A<' &"' C:#Y+,"+;:,'
FO$,'7"$_'FO",7+PQ,%'48;'A"+Y&%'%7'FO$,'1(Z'?48'+,F>7%C7"Y&%'F",;'&%';>9$#';%9"+7'69>F+C7+A'
FO$,%'6%97%'69:P9%;;+E%'F%'&O",7+PQ,%'48;U'
'
Disparition!de!l’antigène!HBs!sous!traitement.!N%';%$&'79"+7%#%,7'";;:C+>'"E%C'$,%'6%97%'F%'
&O",7+PQ,%' 48;' %7' &O"66"9+7+:,' FO",7+C:96;' ",7+' 48;' %;7' &O+,7%9A>9:,' 6%PR&>' `F",;' ' /.' \' F%;'
C";aU'N"'Y"+;;%'F$'7"$_'FO",7+PQ,%'48;'F",;'&%';>9$#'W'&"'/-Q#%'%7'W'&"'-0Q#%'';%#"+,%';:$;'
79"+7%#%,7'6:$99"+7'b79%'$7+&+;>%'C:##%'#"9S$%$9'69>F+C7+A'F%'9>6:,;%'E+9:&:P+S$%'%7'F",;'
C%97"+,;'C";'F%'6%97%'F%'&O",7+PQ,%'48;U'
Sous!analogue!nucléosidique!ou!nucléotidique<'&%'7"$_'FO",7+PQ,%'48;';:$;'79"+7%#%,7'%;7'
6%$'69>F+C7+A'FO$,%'F+;6"9+7+:,'F%'&O",7+PQ,%'48;';$9'&%'&:,P'7%9#%U'=%6%,F",7'$,'F>C&+,'79Q;'
9"6+F%'F$'7"$_'FO",7+PQ,%'48;';:$;'","&:P$%',$C&>:;+F+S$%'6:$99"+7'+F%,7+A+%9'F%;'6"7+%,7;'
6:$E",7' 6%9F9%' &O",7+PQ,%' 48;U' N%' 7"$_' F%' 6%97%' F%' &O",7+PQ,%' 48;' ;:$;' 79"+7%#%,7' 6"9'
","&:P$%',$C&>:;+F+S$%'%7',$C&>:7+F+S$%'%;7'6&$;'A"+Y&%'S$%';:$;'+,7%9A>9:,'6%PR&>U'
Les!traitements!combinés!c':,';"+7'S$%'&"'6%97%'F%'&O",7+PQ,%'48;'%;7'";;:C+>%'W'&O"#6&+7$F%''
F%' &"' 9>6:,;%' +###$,%' ",7+' 48?U' 2:$9' C%77%' 9"+;:,' +&' %;7' "66"9$' &:P+S$%' F%' 7%,7%9' F%;'
C:#Y+,"+;:,;' "E%C' FO$,%' 6"97' F%;' ","&:P$%;' ,$C&>:;+F+S$%;' :$' ,$C&>:7+F+S$%;' C"6"Y&%;'
FO+,T+Y%9'&"'9%6&+C"7+:,'E+9"&%'%7'FO"$79%'6"97'"E%C'&O+,7%9A%9:,'6%PR&>'C"6"Y&%'F%';7+#$&%9'$,%'
9>6:,;%'+##$,%'",7+'E+9"&%U'=%77%'"669:CT%'"'$,'9"7+:,,%&'&:P+S$%U'
2&$;+%$9;' %;;"+;' C:#Y+,>;' ";;:C+",7' F%;' ","&:P$%;' ,$C&>:7+F+S$%;' :$' ,$C&>:;+F+S$%;' "E%C'
&O+,7%9A>9:,' 6>PR&>' ;:+7' F",;' &%' #b#%' 7%#6;<' ;:+7' F%' A"d:,' ;>S$%,7+%&&%' F",;' F%;' :9F9%;'
F+AA>9%,7;' :,7' %,' A"+7' F:,,>' F%;' 9>;$&7"7;' F>C%E",7;' ,O"$P#%,7",7' 6";' &%' 7"$_' F%'
,>P"7+E"7+:,'F%'&O",7+PQ,%'48;'6"9'9"66:97'W'&O+,7%9A>9:,'6%PR&>';%$&U'
'
En! conclusion!c' (%;' 69:P9Q;' ;6%C7"C$&"+9%;' F",;' &%' 79"+7%#%,7' F%' &OT>6"7+7%' 8' :,7' >7>' A"+7;'
"E%C'&O"EQ,%#%,7'F%;'","&:P$%;',$C&>:;+F+S$%;':$',$C&>:7+F+S$%;'C"6"Y&%;'F%'#"+,7%,+9'&"'
E+9:;$669%;;+:,' %7' &O+,F>7%C7"Y+&+7>' F%' &O1(Z' F$' E+9$;' F%' &OT>6"7+7%' 8' ;$9' &%' &:,P' 7%9#%U'
=%6%,F",7'C%;'79"+7%#%,7;',%';$669+#%,7'6";'''&"'69>;%,C%'F%'CCC(Z1'F",;'&%'A:+%'%7'F:,C'
,%';$669+#%,7'6";'&%'9+;S$%'F%'9>"C7+E"7+:,'E+9"&%'8'W'&O"99b7'F%;'79"+7%#%,7;U'(%;'"669:CT%;'
!"#$%&'()*+&,-."/"01'()#(2'%.$'(+&,-."341/1-1$'(5(67(8#1%(9:6;(5(<-$1=>(?$-%@'(
!"#$%&'(')'*$+,'-./0' '
]'
C:#Y+,>%;' ,%' ;%' ;:,7' 6";' 9>E>&>%;' ;$6>9+%$9%;' W' &O+,7%9A>9:,' 6%PR&>' ;%$&' 6:$9' :Y7%,+9' &"'
6%97%' F%' &O",7+PQ,%' 48;U' NO:Y7%,7+:,' F%' &"' P$>9+;:,' C:#6&Q7%' %7' F%' &"' ;>9:' C:,E%9;+:,'
",7+PQ,%'48;''['",7+C:96;'",7+'48;'%;7'Y+%,'&O:Y@%C7+A'69+,C+6"&'F%'&"'9%CT%9CT%';$9'&%'E+9$;'F%'
&OT>6"7+7%'8'F",;'&%;'",,>%;'A$7$9%;U''
'
1 / 3 100%
La catégorie de ce document est-elle correcte?
Merci pour votre participation!

Faire une suggestion

Avez-vous trouvé des erreurs dans linterface ou les textes ? Ou savez-vous comment améliorer linterface utilisateur de StudyLib ? Nhésitez pas à envoyer vos suggestions. Cest très important pour nous !