RAPPEL Dans le cadre des Forums d’infectiologie organisés par le CIRI, nous vous rappelons que nous aurons le plaisir d’accueillir : le Dr. Giorgio TRINCHIERI le jeudi 7 mars 2013 à 11h à l’amphithéâtre Pasteur (RdC Tour Inserm CERVI) 21, avenue Tony Garnier – 69007 Lyon Titre de son intervention : « Microbiota and response to cancer therapy » Giorgio Trinchieri (MD, PhD) is an immunologist of worldwide notoriety who investigated for many years the role of proinflammatory cytokines and interferons in the regulation of haematopoiesis and innate immunity. His pioneer work is the discovery of Interleukin-12, its production and mode of action in antitumour immunity, infection and autoimmunity. As a former director of the Schering Plough Laboratory for Immunological Research in Dardilly (France), he established a program of biology and drug discovery for targeting innate immunity and developed protocols of cancer immunotherapy. His main focus of research is presently the role of inflammation, innate resistance, and immunity in carcinogenesis, cancer progression, and prevention or destruction of cancer. No need to say, his seminar will certainly be of great value for all researchers beyond those working on cancer. Looking forward to seeing you on march 7, 11:00 am ! Dominique Kaiserlian References Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, Taniguchi K, Yu GY, Osterreicher CH, Hung KE, Datz C, Feng Y, Fearon ER, Oukka M, Tessarollo L, Coppola V, Yarovinsky F, Cheroutre H, Eckmann L, Trinchieri G, Karin M. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature. 2012. 491(7423):254-8. Cataisson C, Salcedo R, Hakim S, Moffitt BA, Wright L, Yi M, Stephens R, Dai RM, Lyakh L, Schenten D, Yuspa HS, Trinchieri G. IL-1R-MyD88 signaling in keratinocyte transformation and carcinogenesis. J. Exp Med. 2012. 209(9):1689-702. Goldszmid RS, Caspar P, Rivollier A, White S, Dzutsev A, Hieny S, Kelsall B, Trinchieri G, Sher A. NK cell-derived interferon-γ orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infection. Immunity. 2012. 36(6):1047-59. Trinchieri G. Cancer and inflammation : an old intuition with rapidly evolving new concepts.. Annu Rev Immunol. 2012;30:677-706. Pour tout renseignement complémentaire, vous trouverez l’affiche de ce forum en pièce jointe. Merci aux visiteurs de se munir d’une pièce d’identité valide (carte d’identité ou passeport) pour accéder à l’amphithéâtre. Venez nombreux ! Béatrice RENAUDIN Assistante de l’Unité de Biologie des Infections Virales Emergentes CNR des Fièvres Hémorragiques Virales – CNR des Hantavirus Centre International de Recherche en Infectiologie (CIRI) INSTITUT PASTEUR 21, avenue Tony Garnier 69365 Lyon Cedex 07 Tél : +33.(0)4.37.28.24.40 Fax : +33.(0)4.37.28.24.41 [email protected]