lettre*d`information - Canceropole Grand ouest

!
Responsable*de*l’axe*Valorisation*des*produits*de*la*mer:*Pr*Sylvain*Routier*
sylvain.routier@univ;orleans.fr*;*02*38*49*48*53*
Responsable*du*Réseau*Canaux*ioniques*et*cancer*:*Pr*Christophe*Vandier*
christophe.vandier@univ;tours.fr*;*02*47*36*60*24*
* *
*
*LETTRE*D’INFORMATION*
SOMMAIRE* *
*
Actualités************************p1*
Zoom*sur…*la*soutenance*de*thèse*de*Camille*Juin******p2*
Zoom*sur…*la*soutenance*de*thèse*de*Laure*Peyta******p3*
Zoom*sur…*la*soutenance*de*thèse*de*Maxime*Guéguinou****p4*
Autres*soutenances*de*l’axe*et*du*réseau*******p5*
Publications"**********p6*
**************
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Axe*Valorisation*des*produits*de*la*mer*en*cancérologie*
et*Réseau*Canaux*ioniques*et*cancer*
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sylvain.routier@univ;orleans.fr*;*02*38*49*48*53*
Responsable*du*Réseau*Canaux*ioniques*et*cancer*:*Pr*Christophe*Vandier*
christophe.vandier@univ;tours.fr*;*02*47*36*60*24*
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Le*premier*objectif*de*la*thèse*était*de*comprendre*les*mécanismes*
à* l’origine* de* l’accumulation* des* cardiolipines* dans* les*
mitochondries*hépatiques*des*rats*cachectiques.">)7"%(3,34N".=-!"!&"
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Le* second* objectif* était* d’étudier* in# vitro# l’impact* de* la*
diminution* de* la* quantité* de* cardiolipines* sur* le*
gaspillage* énergétique* mitochondrial* hépatiqueF" H)%"
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"
Figure 1 : La dénutrition induite par le
cancer : balance énergétique négative
et conséquences chez le patient.

\
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G&%3776J4)".)"G)%6%)"$&+.4$%3+$)"3$%6,/"G3("5)"H30w"6+%(3$)554536()Q"
)7%"6-G56J4/".3+7"5)"G(&$)7747".)"-6;(3%6&+".)7"$)5545)7"/G6%I/5635)7"
.)"$3+$)(".4"7)6+")%".4"-/53+&-)F""
"
^+"01!8?"5Y/J46G)"3"-&+%(/"J4)"5)"$3+35"Cn8"/%36%"5&$3567/".3+7".)7"
+3+&.&-36+)7"56G6.6J4)7"O3GG)5/7"(3.)34N"56G6.6J4)7Q"3,)$"5)"$3+35"
$35$6J4)" #(36!F" >3" L&(-3%6&+" .)" $)" $&-G5)N)" $3+3536()" .3+7" $)%"
)+,6(&++)-)+%" 56G6.6J4)" )7%" ()7G&+73'5)" ._4+" 6+L54N" $35$6J4)"
$&+7%6%4%6L" -&.453+%" 53" -6;(3%6&+" .)7" $)5545)7" $3+$/()47)7" .4"7)6+"
36+76"J4)"5)"./,)5&GG)-)+%".)"-/%37%37)7"&77)47)7"OHI3+%Z-)".;-
#8?"01!8QF""
>3"%IA7)" .)" j3N6-)" 3,36%" G&4(" &'K)$%6L7" .)" $3(3$%/(67)(" 5)7" ,&6)7"
.Y)+%(/)7" .)" H30w"./G)+.3+%)7" .4" $3+35" Cn8" .3+7" 5)7" $)5545)7"
$3+$/()47)7" .4" $&5&+" )%" .)" 53" G(&7%3%)" G&4,3+%" 36+76" ./L6+6(" 4+)"
76;+3%4()" $35$6J4)" )%" .&+$" 4+)" (/G&+7)" GI=76&5&;6J4)" '6)+" ./L6+6)"
377&$6/)" 34" $&-G5)N)" L&(-/" G3("5)7" $3+34N"$35$6J4)7" O#(367" )%S&4"
l:<7Q")%"34"$3+35"Cn8F""C)7"%(3,34N"&+%"G)(-67".Y6.)+%6L6)(?".3+7"5)7"
$)5545)7" $3+$/()47)7" $&56J4)7?" 4+" +&4,)34" $&-G5)N)" $3+3536()"
377&$63+%" 5)7" $3+34N" l:<H!S#(36!SCn8SClaj!" 34" 7)6+" .)"
+3+&.&-36+)7"-)-'(3+36()7F"H)"$&-G5)N)?")+"(/;453+%"4+)")+%(/)"
$35$6J4)" 3$%6,/)" G3(" 53" ./G5/%6&+" )+" H30w" .4" (/%6$454-"
)+.&G537-6J4)" OC#H^"T" 7%&()*&G)(3%)." $35$64-" )+%(=Q" L3,&(67)" 53"
-6;(3%6&+"$)5545)7"$3+$/()47)7"$&56J4)7"O[6;4()"!QF""
H&--)" -67" )+" /,6.)+$)" .3+7" 5)" $3+$)(" .4" 7)6+?" 4+" 35e=5*
GI&7GI&56G6.)" .)" 7=+%IA7)" 5Y#I-56+)?" 6+I6'6%)4(" .4" $3+35" Cn8?"
.677&$6)" 5)" $&-G5)N)" I&(7" .)7" (3.)34N*56G6.)7" )%" .)" G547?" )7%"
$3G3'5)" .)" -&.6L6)(" 5Y3$%6&+" .Y3+%6$&(G7" -&+&$5&+34N"
%I/(3G)4%6J4)7" O<3+6%4+4-3'" )%" H/%4N6-3'Q" 74(" 53" -6;(3%6&+"
$)554536()"./G)+.3+%)".)"5Y6+L54N"C#H^F""
H"3+'.-5-J-OP8.-*+--
"
"
>)" G(&K)%" " H:anjD<De%?" L6+3+$/" .)" 011m" B" 01!!" G3(" 53" :/;6&+"
H)+%()?" /%36%" $&&(.&++/" G3(" %(&67"/J46G)7"&(5/3+367)7F" @)4N" .)"
'6&5&;6)" OHhj?" H]:C" i<:" \81!Q" .6(6;/)7" ()7G)$%6,)-)+%" G3(" ["
C$I&)+%;)+")%"k"h/+/.)%%6")%"4+)".)"$I6-6)?"C":&4%6)("OaH#D?"ij:"
H]:C"V8!!QF">)7"&'K)$%6L7".)"$)"G(&;(3--)"/%36)+%"T"
!8Q .)" $&+7%6%4)(" 4+" G53%)34" .)" %)7%7" '6&5&;6J4)7" G&4(" .&7)("
5Y3$%6,6%/" .)7" G(&%/6+)7" e6+37)7" .)7" ,&6)7" jD<" e6+37)7"
:3LSj^nS^:n"G467"<a8nSDnlS-l#:?" $)7",&6)7"+Y/%3+%"G547"
(/;45/)7".3+7".)"+&-'()4N"$3+$)(7?"
!\Q .)" ./,)5&GG)(" .)7" -&5/$45)7" $3G3'5)7" .Y6+I6')(" 5)7"
)+M=-)7".)"$)7".)4N",&6)7".)"76;+35673%6&+F"
Tests*biologiques""
>)7" /%4.)7" .)" 53" ,&6)" :3LSj^nS^:n?" 5)7" %)7%7" -67" 34" G&6+%" )%" 5)7"
6+I6'6%)4(7" .)" :D[" 7=+%I/%67/7" &+%" L36%" 5Y&'K)%" .Y4+" 3(%6$5)" .3+7" 53"
5)%%()".Y6+L&(-3%6&+".)"5Y3N)"W"K3+,6)(*L/,(6)("01!1"X?"$)%%)"G3(%6)".4"
G(&K)%"+)"7)(3".&+$"G37"./,)5&GG/)".)"+&4,)34F"
>3" ,&6)" <a8nSDe%S-l#:" )7%" 4+)" ,&6)" .)" 76;+35673%6&+" 74(3$%6,/)"
.3+7" .)" +&-'()4N" $3+$)(7F" C3" 74(3$%6,3%6&+" )7%" 4+" L3$%)4(" .)"
(/767%3+$)"B"53"$I6-6&%I/(3G6)".3+7"$)(%36+7"$3+$)(7F""
<a8n" )7%" 3$%6,/)" G3(" .)7" (/$)G%)4(7" B" %=(&76+)" e6+37)" )%" .)7"
(/$)G%)4(7" $&4G5/7" 34N" G(&%/6+)7" EF" i+)" L&67" 3$%6,/)?" <a8n" ,3"
GI&7GI&(=5)(" 4+" GI&7GI&56G6.)" -)-'(3+36()" 5)" <a<0" )+" <a<8F" H)"
.)(+6)(" 3" .)" 5Y3LL6+6%/" G&4(" .)7" .&-36+)7" <k" OG5)$e7%(6+"
I&-&5&;&47".&-36+Q".)7"e6+37)7"De%")%"<@n!")%",3"5)7"()$(4%)("B"53"
-)-'(3+)F"De%",3"="P%()"GI&7GI&(=5/)")%"3$%6,/)F"i+)"L&67"3$%6,/)?"
)55)",3"G&4,&6("GI&7GI&(=5)("4+";(3+."+&-'()".)"$6'5)7"$)554536()7"
6-G56J4/)7" .3+7" .6LL/()+%7" G(&$)7747" %)57" J4)" 5Y3+;6&;)+A7)?" 53"
G(&;()776&+" .4" $=$5)" $)554536()?" 53" 74(,6)" $)554536()?" 53"7=+%IA7)" .)"
;5=$&;A+)")%"53"$(&6773+$)"$)554536()"!"#"53"e6+37)"-l#:"34"7)6+".4"
$&-G5)N)"-l#:H!F"
@)7"6+I6'6%)4(7".)"-l#:")%".YDe%"&+%"./KB"/%/"./,)5&GG/7")%"%)7%/7"
)+" )77367" $56+6J4)7" .)" GI37)" a?" aa" )%" aaaF" ^N$)G%/" .3+7" 5)" $37" .4"
$3($6+&-)" (/+35?" 65" 3GG3(3o%" J4)" $)7" 6+I6'6%)4(7" &+%" .)7" )LL)%7"
./$),3+%7F"H)7"(/745%3%7"&+%"/%/"(/$)--)+%"$&-G(67"4+)"L&67"J4)"53"
,&6)"De%"36%"/%/"-6)4N"/%4.6/)F"@Y4+)"G3(%?"5)7".)4N"e6+37)7"De%")%"
-l#:"G)4,)+%"P%()"$&4($6($46%/)7"G3("5)"L36%"J4)"<@n!")7%"$3G3'5)"
.Y3$%6,)(".6()$%)-)+%"53"C9e6+37)F"@Y34%()"G3(%?"65")N67%)"4+)",&6)".)"
(/%(&$&+%(Z5)" .)" 5Y3$%6,3%6&+" .)" <a8n" G3(" -l#:F" D6+76?" 5&(7J4)"
-l#:")7%"6+I6'/)?"<a8n"+)"G)4%"G547"5YP%()F"D5&(7?"<a8n",3"P%()"G547"
3$%6,/)")%"B"%)(-)?"4+")LL)%"()'&+.".)"5Y3$%6,3%6&+".)"53",&6)")%".&+$"
.YDe%" )%" .)" -l#:" 7)" G(&.46%F" a5" 3GG3(3o%" J4)" 76" 5Y&+" ,)4%" 6+I6')("
)LL6$3$)-)+%"53",&6)?"53"e6+37)"J4Y65"L34%"$6'5)(")7%"53"G()-6A()".)"53"
,&6)" <a8n" -367" -l#:" G)4%*P%()" 3$%6,/)" 6+./G)+.3--)+%" .)" <a8n"
,63"+&%3--)+%"53",&6)":3LSj^nS^:nF""
"
H)%%)" 7%(3%/;6)" )7%" .Y34%3+%" G547" (/3567%)" J4)" <a8n" )%" -l#:"
3GG3(%6)++)+%" B" 53" -P-)" L3-655)" .)" e6+37)7" )%" J4)" .)" %(A7" '&+7"
6+I6'6%)4(7".&4'5)7"G)4,)+%"P%()"./,)5&GG/7F""
"
>)" G(&K)%" " H:anjD<De%?" L6+3+$/" .)" 011m" B" 01!!" G3(" 53" :/;6&+"
H)+%()?" /%36%" $&&(.&++/" G3(" %(&67"/J46G)7"&(5/3+367)7F" @)4N" .)"
'6&5&;6)" OHhj?" H]:C" i<:" \81!Q" .6(6;/)7" ()7G)$%6,)-)+%" G3(" ["
C$I&)+%;)+")%"k"h/+/.)%%6")%"4+)".)"$I6-6)?"C":&4%6)("OaH#D?"ij:"
H]:C"V8!!QF">)7"&'K)$%6L7".)"$)"G(&;(3--)"/%36)+%"T"
!2Q .)" $&+7%6%4)(" 4+" G53%)34" .)" %)7%7" '6&5&;6J4)7" G&4(" .&7)("
5Y3$%6,6%/" .)7" G(&%/6+)7" e6+37)7" .)7" ,&6)7" jD<" e6+37)7"
:3LSj^nS^:n"G467"<a8nSDnlS-l#:?" $)7",&6)7"+Y/%3+%"G547"
(/;45/)7".3+7".)"+&-'()4N"$3+$)(7?"
!9Q .)" ./,)5&GG)(" .)7" -&5/$45)7" $3G3'5)7" .Y6+I6')(" 5)7"
)+M=-)7".)"$)7".)4N",&6)7".)"76;+35673%6&+F"
Tests*biologiques""
>)7" /%4.)7" .)" 53" ,&6)" :3LSj^nS^:n?" 5)7" %)7%7" -67" 34" G&6+%" )%" 5)7"
6+I6'6%)4(7" .)" :D[" 7=+%I/%67/7" &+%" L36%" 5Y&'K)%" .Y4+" 3(%6$5)" .3+7" 53"
5)%%()".Y6+L&(-3%6&+".)"5Y3N)"W"K3+,6)(*L/,(6)("01!1"X?"$)%%)"G3(%6)".4"
G(&K)%"+)"7)(3".&+$"G37"./,)5&GG/)".)"+&4,)34F"
>3" ,&6)" <a8nSDe%S-l#:" )7%" 4+)" ,&6)" .)" 76;+35673%6&+" 74(3$%6,/)"
.3+7" .)" +&-'()4N" $3+$)(7F" C3" 74(3$%6,3%6&+" )7%" 4+" L3$%)4(" .)"
(/767%3+$)"B"53"$I6-6&%I/(3G6)".3+7"$)(%36+7"$3+$)(7F""
<a8n" )7%" 3$%6,/)" G3(" .)7" (/$)G%)4(7" B" %=(&76+)" e6+37)" )%" .)7"
(/$)G%)4(7" $&4G5/7" 34N" G(&%/6+)7" EF" i+)" L&67" 3$%6,/)?" <a8n" ,3"
GI&7GI&(=5)(" 4+" GI&7GI&56G6.)" -)-'(3+36()" 5)" <a<0" )+" <a<8F" H)"
.)(+6)(" 3" .)" 5Y3LL6+6%/" G&4(" .)7" .&-36+)7" <k" OG5)$e7%(6+"
I&-&5&;&47".&-36+Q".)7"e6+37)7"De%")%"<@n!")%",3"5)7"()$(4%)("B"53"
-)-'(3+)F"De%",3"="P%()"GI&7GI&(=5/)")%"3$%6,/)F"i+)"L&67"3$%6,/)?"
)55)",3"G&4,&6("GI&7GI&(=5)("4+";(3+."+&-'()".)"$6'5)7"$)554536()7"
6-G56J4/)7" .3+7" .6LL/()+%7" G(&$)7747" %)57" J4)" 5Y3+;6&;)+A7)?" 53"
G(&;()776&+" .4" $=$5)" $)554536()?" 53" 74(,6)" $)554536()?" 53"7=+%IA7)" .)"
;5=$&;A+)")%"53"$(&6773+$)"$)554536()"!"#"53"e6+37)"-l#:"34"7)6+".4"
$&-G5)N)"-l#:H!F"
@)7"6+I6'6%)4(7".)"-l#:")%".YDe%"&+%"./KB"/%/"./,)5&GG/7")%"%)7%/7"
)+" )77367" $56+6J4)7" .)" GI37)" a?" aa" )%" aaaF" ^N$)G%/" .3+7" 5)" $37" .4"
$3($6+&-)" (/+35?" 65" 3GG3(3o%" J4)" $)7" 6+I6'6%)4(7" &+%" .)7" )LL)%7"
./$),3+%7F"H)7"(/745%3%7"&+%"/%/"(/$)--)+%"$&-G(67"4+)"L&67"J4)"53"
,&6)"De%"36%"/%/"-6)4N"/%4.6/)F"@Y4+)"G3(%?"5)7".)4N"e6+37)7"De%")%"
-l#:"G)4,)+%"P%()"$&4($6($46%/)7"G3("5)"L36%"J4)"<@n!")7%"$3G3'5)"
.Y3$%6,)(".6()$%)-)+%"53"C9e6+37)F"@Y34%()"G3(%?"65")N67%)"4+)",&6)".)"
(/%(&$&+%(Z5)" .)" 5Y3$%6,3%6&+" .)" <a8n" G3(" -l#:F" D6+76?" 5&(7J4)"
-l#:")7%"6+I6'/)?"<a8n"+)"G)4%"G547"5YP%()F"D5&(7?"<a8n",3"P%()"G547"
3$%6,/)")%"B"%)(-)?"4+")LL)%"()'&+.".)"5Y3$%6,3%6&+".)"53",&6)")%".&+$"
.YDe%" )%" .)" -l#:" 7)" G(&.46%F" a5" 3GG3(3o%" J4)" 76" 5Y&+" ,)4%" 6+I6')("
)LL6$3$)-)+%"53",&6)?"53"e6+37)"J4Y65"L34%"$6'5)(")7%"53"G()-6A()".)"53"
,&6)" <a8n" -367" -l#:" G)4%*P%()" 3$%6,/)" 6+./G)+.3--)+%" .)" <a8n"
,63"+&%3--)+%"53",&6)":3LSj^nS^:nF""
"
H)%%)" 7%(3%/;6)" )7%" .Y34%3+%" G547" (/3567%)" J4)" <a8n" )%" -l#:"
3GG3(%6)++)+%" B" 53" -P-)" L3-655)" .)" e6+37)7" )%" J4)" .)" %(A7" '&+7"
6+I6'6%)4(7".&4'5)7"G)4,)+%"P%()"./,)5&GG/7F""
"
>)" G(&K)%" " H:anjD<De%?" L6+3+$/" .)" 011m" B" 01!!" G3(" 53" :/;6&+"
H)+%()?" /%36%" $&&(.&++/" G3(" %(&67"/J46G)7"&(5/3+367)7F" @)4N" .)"
'6&5&;6)" OHhj?" H]:C" i<:" \81!Q" .6(6;/)7" ()7G)$%6,)-)+%" G3(" ["
C$I&)+%;)+")%"k"h/+/.)%%6")%"4+)".)"$I6-6)?"C":&4%6)("OaH#D?"ij:"
H]:C"V8!!QF">)7"&'K)$%6L7".)"$)"G(&;(3--)"/%36)+%"T"
!VQ .)" $&+7%6%4)(" 4+" G53%)34" .)" %)7%7" '6&5&;6J4)7" G&4(" .&7)("
5Y3$%6,6%/" .)7" G(&%/6+)7" e6+37)7" .)7" ,&6)7" jD<" e6+37)7"
:3LSj^nS^:n"G467"<a8nSDnlS-l#:?" $)7",&6)7"+Y/%3+%"G547"
(/;45/)7".3+7".)"+&-'()4N"$3+$)(7?"
!qQ .)" ./,)5&GG)(" .)7" -&5/$45)7" $3G3'5)7" .Y6+I6')(" 5)7"
)+M=-)7".)"$)7".)4N",&6)7".)"76;+35673%6&+F"
Tests*biologiques""
>)7" /%4.)7" .)" 53" ,&6)" :3LSj^nS^:n?" 5)7" %)7%7" -67" 34" G&6+%" )%" 5)7"
6+I6'6%)4(7" .)" :D[" 7=+%I/%67/7" &+%" L36%" 5Y&'K)%" .Y4+" 3(%6$5)" .3+7" 53"
5)%%()".Y6+L&(-3%6&+".)"5Y3N)"W"K3+,6)(*L/,(6)("01!1"X?"$)%%)"G3(%6)".4"
G(&K)%"+)"7)(3".&+$"G37"./,)5&GG/)".)"+&4,)34F"
>3" ,&6)" <a8nSDe%S-l#:" )7%" 4+)" ,&6)" .)" 76;+35673%6&+" 74(3$%6,/)"
.3+7" .)" +&-'()4N" $3+$)(7F" C3" 74(3$%6,3%6&+" )7%" 4+" L3$%)4(" .)"
(/767%3+$)"B"53"$I6-6&%I/(3G6)".3+7"$)(%36+7"$3+$)(7F""
<a8n" )7%" 3$%6,/)" G3(" .)7" (/$)G%)4(7" B" %=(&76+)" e6+37)" )%" .)7"
(/$)G%)4(7" $&4G5/7" 34N" G(&%/6+)7" EF" i+)" L&67" 3$%6,/)?" <a8n" ,3"
GI&7GI&(=5)(" 4+" GI&7GI&56G6.)" -)-'(3+36()" 5)" <a<0" )+" <a<8F" H)"
.)(+6)(" 3" .)" 5Y3LL6+6%/" G&4(" .)7" .&-36+)7" <k" OG5)$e7%(6+"
I&-&5&;&47".&-36+Q".)7"e6+37)7"De%")%"<@n!")%",3"5)7"()$(4%)("B"53"
-)-'(3+)F"De%",3"="P%()"GI&7GI&(=5/)")%"3$%6,/)F"i+)"L&67"3$%6,/)?"
)55)",3"G&4,&6("GI&7GI&(=5)("4+";(3+."+&-'()".)"$6'5)7"$)554536()7"
6-G56J4/)7" .3+7" .6LL/()+%7" G(&$)7747" %)57" J4)" 5Y3+;6&;)+A7)?" 53"
G(&;()776&+" .4" $=$5)" $)554536()?" 53" 74(,6)" $)554536()?" 53"7=+%IA7)" .)"
;5=$&;A+)")%"53"$(&6773+$)"$)554536()"!"#"53"e6+37)"-l#:"34"7)6+".4"
$&-G5)N)"-l#:H!F"
@)7"6+I6'6%)4(7".)"-l#:")%".YDe%"&+%"./KB"/%/"./,)5&GG/7")%"%)7%/7"
)+" )77367" $56+6J4)7" .)" GI37)" a?" aa" )%" aaaF" ^N$)G%/" .3+7" 5)" $37" .4"
$3($6+&-)" (/+35?" 65" 3GG3(3o%" J4)" $)7" 6+I6'6%)4(7" &+%" .)7" )LL)%7"
./$),3+%7F"H)7"(/745%3%7"&+%"/%/"(/$)--)+%"$&-G(67"4+)"L&67"J4)"53"
,&6)"De%"36%"/%/"-6)4N"/%4.6/)F"@Y4+)"G3(%?"5)7".)4N"e6+37)7"De%")%"
-l#:"G)4,)+%"P%()"$&4($6($46%/)7"G3("5)"L36%"J4)"<@n!")7%"$3G3'5)"
.Y3$%6,)(".6()$%)-)+%"53"C9e6+37)F"@Y34%()"G3(%?"65")N67%)"4+)",&6)".)"
(/%(&$&+%(Z5)" .)" 5Y3$%6,3%6&+" .)" <a8n" G3(" -l#:F" D6+76?" 5&(7J4)"
-l#:")7%"6+I6'/)?"<a8n"+)"G)4%"G547"5YP%()F"D5&(7?"<a8n",3"P%()"G547"
3$%6,/)")%"B"%)(-)?"4+")LL)%"()'&+.".)"5Y3$%6,3%6&+".)"53",&6)")%".&+$"
.YDe%" )%" .)" -l#:" 7)" G(&.46%F" a5" 3GG3(3o%" J4)" 76" 5Y&+" ,)4%" 6+I6')("
)LL6$3$)-)+%"53",&6)?"53"e6+37)"J4Y65"L34%"$6'5)(")7%"53"G()-6A()".)"53"
,&6)" <a8n" -367" -l#:" G)4%*P%()"3$%6,/)" 6+./G)+.3--)+%" .)" <a8n"
,63"+&%3--)+%"53",&6)":3LSj^nS^:nF""
"
H)%%)" 7%(3%/;6)" )7%" .Y34%3+%" G547" (/3567%)" J4)" <a8n" )%" -l#:"
3GG3(%6)++)+%" B" 53" -P-)" L3-655)" .)" e6+37)7" )%" J4)" .)" %(A7" '&+7"
6+I6'6%)4(7".&4'5)7"G)4,)+%"P%()"./,)5&GG/7F""
"
>)" G(&K)%" " H:anjD<De%?" L6+3+$/" .)" 011m" B" 01!!" G3(" 53" :/;6&+"
H)+%()?" /%36%" $&&(.&++/" G3(" %(&67"/J46G)7"&(5/3+367)7F" @)4N" .)"
'6&5&;6)" OHhj?" H]:C" i<:" \81!Q" .6(6;/)7" ()7G)$%6,)-)+%" G3(" ["
C$I&)+%;)+")%"k"h/+/.)%%6")%"4+)".)"$I6-6)?"C":&4%6)("OaH#D?"ij:"
H]:C"V8!!QF">)7"&'K)$%6L7".)"$)"G(&;(3--)"/%36)+%"T"
!mQ .)" $&+7%6%4)(" 4+" G53%)34" .)" %)7%7" '6&5&;6J4)7" G&4(" .&7)("
5Y3$%6,6%/" .)7" G(&%/6+)7" e6+37)7" .)7" ,&6)7" jD<" e6+37)7"
:3LSj^nS^:n"G467"<a8nSDnlS-l#:?" $)7",&6)7"+Y/%3+%"G547"
(/;45/)7".3+7".)"+&-'()4N"$3+$)(7?"
01Q .)" ./,)5&GG)(" .)7" -&5/$45)7" $3G3'5)7" .Y6+I6')(" 5)7"
)+M=-)7".)"$)7".)4N",&6)7".)"76;+35673%6&+F"
Tests*biologiques""
>)7" /%4.)7" .)" 53" ,&6)" :3LSj^nS^:n?" 5)7" %)7%7" -67" 34" G&6+%" )%" 5)7"
6+I6'6%)4(7" .)" :D[" 7=+%I/%67/7" &+%" L36%" 5Y&'K)%" .Y4+" 3(%6$5)" .3+7" 53"
5)%%()".Y6+L&(-3%6&+".)"5Y3N)"W"K3+,6)(*L/,(6)("01!1"X?"$)%%)"G3(%6)".4"
G(&K)%"+)"7)(3".&+$"G37"./,)5&GG/)".)"+&4,)34F"
>3" ,&6)" <a8nSDe%S-l#:" )7%" 4+)" ,&6)" .)" 76;+35673%6&+" 74(3$%6,/)"
.3+7" .)" +&-'()4N" $3+$)(7F" C3" 74(3$%6,3%6&+" )7%" 4+" L3$%)4(" .)"
(/767%3+$)"B"53"$I6-6&%I/(3G6)".3+7"$)(%36+7"$3+$)(7F""
<a8n" )7%" 3$%6,/)" G3(" .)7" (/$)G%)4(7" B" %=(&76+)" e6+37)" )%" .)7"
(/$)G%)4(7" $&4G5/7" 34N" G(&%/6+)7" EF" i+)" L&67" 3$%6,/)?" <a8n" ,3"
GI&7GI&(=5)(" 4+" GI&7GI&56G6.)" -)-'(3+36()" 5)" <a<0" )+" <a<8F" H)"
.)(+6)(" 3" .)" 5Y3LL6+6%/" G&4(" .)7" .&-36+)7" <k" OG5)$e7%(6+"
I&-&5&;&47".&-36+Q".)7"e6+37)7"De%")%"<@n!")%",3"5)7"()$(4%)("B"53"
-)-'(3+)F"De%",3"="P%()"GI&7GI&(=5/)")%"3$%6,/)F"i+)"L&67"3$%6,/)?"
)55)",3"G&4,&6("GI&7GI&(=5)("4+";(3+."+&-'()".)"$6'5)7"$)554536()7"
6-G56J4/)7" .3+7" .6LL/()+%7" G(&$)7747" %)57" J4)" 5Y3+;6&;)+A7)?" 53"
G(&;()776&+" .4" $=$5)" $)554536()?" 53" 74(,6)" $)554536()?" 53"7=+%IA7)" .)"
;5=$&;A+)")%"53"$(&6773+$)"$)554536()"!"#"53"e6+37)"-l#:"34"7)6+".4"
$&-G5)N)"-l#:H!F"
@)7"6+I6'6%)4(7".)"-l#:")%".YDe%"&+%"./KB"/%/"./,)5&GG/7")%"%)7%/7"
)+" )77367" $56+6J4)7" .)" GI37)" a?" aa" )%" aaaF" ^N$)G%/" .3+7" 5)" $37" .4"
$3($6+&-)" (/+35?" 65" 3GG3(3o%" J4)" $)7" 6+I6'6%)4(7" &+%" .)7" )LL)%7"
./$),3+%7F"H)7"(/745%3%7"&+%"/%/"(/$)--)+%"$&-G(67"4+)"L&67"J4)"53"
,&6)"De%"36%"/%/"-6)4N"/%4.6/)F"@Y4+)"G3(%?"5)7".)4N"e6+37)7"De%")%"
-l#:"G)4,)+%"P%()"$&4($6($46%/)7"G3("5)"L36%"J4)"<@n!")7%"$3G3'5)"
.Y3$%6,)(".6()$%)-)+%"53"C9e6+37)F"@Y34%()"G3(%?"65")N67%)"4+)",&6)".)"
(/%(&$&+%(Z5)" .)" 5Y3$%6,3%6&+" .)" <a8n" G3(" -l#:F" D6+76?" 5&(7J4)"
-l#:")7%"6+I6'/)?"<a8n"+)"G)4%"G547"5YP%()F"D5&(7?"<a8n",3"P%()"G547"
3$%6,/)")%"B"%)(-)?"4+")LL)%"()'&+.".)"5Y3$%6,3%6&+".)"53",&6)")%".&+$"
.YDe%" )%" .)" -l#:" 7)" G(&.46%F" a5" 3GG3(3o%" J4)" 76" 5Y&+" ,)4%" 6+I6')("
)LL6$3$)-)+%"53",&6)?"53"e6+37)"J4Y65"L34%"$6'5)(")7%"53"G()-6A()".)"53"
,&6)" <a8n" -367" -l#:" G)4%*P%()" 3$%6,/)" 6+./G)+.3--)+%" .)" <a8n"
,63"+&%3--)+%"53",&6)":3LSj^nS^:nF""
"
H)%%)" 7%(3%/;6)" )7%" .Y34%3+%" G547" (/3567%)" J4)" <a8n" )%" -l#:"
3GG3(%6)++)+%" B" 53" -P-)" L3-655)" .)" e6+37)7" )%" J4)" .)" %(A7" '&+7"
6+I6'6%)4(7".&4'5)7"G)4,)+%"P%()"./,)5&GG/7F""
"
>)" G(&K)%" " H:anjD<De%?" L6+3+$/" .)" 011m"B" 01!!" G3(" 53" :/;6&+"
H)+%()?" /%36%" $&&(.&++/" G3(" %(&67"/J46G)7"&(5/3+367)7F" @)4N" .)"
'6&5&;6)" OHhj?" H]:C" i<:" \81!Q" .6(6;/)7" ()7G)$%6,)-)+%" G3(" ["
C$I&)+%;)+")%"k"h/+/.)%%6")%"4+)".)"$I6-6)?"C":&4%6)("OaH#D?"ij:"
H]:C"V8!!QF">)7"&'K)$%6L7".)"$)"G(&;(3--)"/%36)+%"T"
0!Q .)" $&+7%6%4)(" 4+" G53%)34" .)" %)7%7" '6&5&;6J4)7" G&4(" .&7)("
5Y3$%6,6%/" .)7" G(&%/6+)7" e6+37)7" .)7" ,&6)7" jD<" e6+37)7"
:3LSj^nS^:n"G467"<a8nSDnlS-l#:?" $)7",&6)7"+Y/%3+%"G547"
(/;45/)7".3+7".)"+&-'()4N"$3+$)(7?"
00Q .)" ./,)5&GG)(" .)7" -&5/$45)7" $3G3'5)7" .Y6+I6')(" 5)7"
)+M=-)7".)"$)7".)4N",&6)7".)"76;+35673%6&+F"
Tests*biologiques""
>)7" /%4.)7" .)" 53" ,&6)" :3LSj^nS^:n?" 5)7" %)7%7" -67" 34" G&6+%" )%" 5)7"
6+I6'6%)4(7" .)" :D[" 7=+%I/%67/7" &+%" L36%" 5Y&'K)%" .Y4+" 3(%6$5)" .3+7" 53"
5)%%()".Y6+L&(-3%6&+".)"5Y3N)"W"K3+,6)(*L/,(6)("01!1"X?"$)%%)"G3(%6)".4"
G(&K)%"+)"7)(3".&+$"G37"./,)5&GG/)".)"+&4,)34F"
>3" ,&6)" <a8nSDe%S-l#:" )7%" 4+)" ,&6)" .)" 76;+35673%6&+" 74(3$%6,/)"
.3+7" .)" +&-'()4N" $3+$)(7F" C3" 74(3$%6,3%6&+" )7%" 4+" L3$%)4(" .)"
(/767%3+$)"B"53"$I6-6&%I/(3G6)".3+7"$)(%36+7"$3+$)(7F""
<a8n" )7%" 3$%6,/)" G3(" .)7" (/$)G%)4(7" B" %=(&76+)" e6+37)" )%" .)7"
(/$)G%)4(7" $&4G5/7" 34N" G(&%/6+)7" EF" i+)" L&67" 3$%6,/)?" <a8n" ,3"
GI&7GI&(=5)(" 4+" GI&7GI&56G6.)" -)-'(3+36()" 5)" <a<0" )+" <a<8F" H)"
.)(+6)(" 3" .)" 5Y3LL6+6%/" G&4(" .)7" .&-36+)7" <k" OG5)$e7%(6+"
I&-&5&;&47".&-36+Q".)7"e6+37)7"De%")%"<@n!")%",3"5)7"()$(4%)("B"53"
-)-'(3+)F"De%",3"="P%()"GI&7GI&(=5/)")%"3$%6,/)F"i+)"L&67"3$%6,/)?"
)55)",3"G&4,&6("GI&7GI&(=5)("4+";(3+."+&-'()".)"$6'5)7"$)554536()7"
6-G56J4/)7" .3+7" .6LL/()+%7" G(&$)7747" %)57" J4)" 5Y3+;6&;)+A7)?" 53"
G(&;()776&+" .4" $=$5)" $)554536()?" 53" 74(,6)" $)554536()?" 53"7=+%IA7)" .)"
;5=$&;A+)")%"53"$(&6773+$)"$)554536()"!"#"53"e6+37)"-l#:"34"7)6+".4"
$&-G5)N)"-l#:H!F"
@)7"6+I6'6%)4(7".)"-l#:")%".YDe%"&+%"./KB"/%/"./,)5&GG/7")%"%)7%/7"
)+" )77367" $56+6J4)7" .)" GI37)" a?" aa" )%" aaaF" ^N$)G%/" .3+7" 5)" $37" .4"
$3($6+&-)" (/+35?" 65" 3GG3(3o%" J4)" $)7" 6+I6'6%)4(7" &+%" .)7" )LL)%7"
./$),3+%7F"H)7"(/745%3%7"&+%"/%/"(/$)--)+%"$&-G(67"4+)"L&67"J4)"53"
,&6)"De%"36%"/%/"-6)4N"/%4.6/)F"@Y4+)"G3(%?"5)7".)4N"e6+37)7"De%")%"
-l#:"G)4,)+%"P%()"$&4($6($46%/)7"G3("5)"L36%"J4)"<@n!")7%"$3G3'5)"
.Y3$%6,)(".6()$%)-)+%"53"C9e6+37)F"@Y34%()"G3(%?"65")N67%)"4+)",&6)".)"
(/%(&$&+%(Z5)" .)" 5Y3$%6,3%6&+" .)" <a8n" G3(" -l#:F" D6+76?" 5&(7J4)"
-l#:")7%"6+I6'/)?"<a8n"+)"G)4%"G547"5YP%()F"D5&(7?"<a8n",3"P%()"G547"
3$%6,/)")%"B"%)(-)?"4+")LL)%"()'&+.".)"5Y3$%6,3%6&+".)"53",&6)")%".&+$"
.YDe%" )%" .)" -l#:" 7)" G(&.46%F" a5" 3GG3(3o%" J4)" 76" 5Y&+" ,)4%" 6+I6')("
)LL6$3$)-)+%"53",&6)?"53"e6+37)"J4Y65"L34%"$6'5)(")7%"53"G()-6A()".)"53"
,&6)" <a8n" -367" -l#:" G)4%*P%()" 3$%6,/)" 6+./G)+.3--)+%" .)" <a8n"
,63"+&%3--)+%"53",&6)":3LSj^nS^:nF""
"
H)%%)" 7%(3%/;6)" )7%" .Y34%3+%" G547" (/3567%)" J4)" <a8n" )%" -l#:"
3GG3(%6)++)+%" B" 53" -P-)" L3-655)" .)" e6+37)7" )%" J4)" .)" %(A7" '&+7"
6+I6'6%)4(7".&4'5)7"G)4,)+%"P%()"./,)5&GG/7F""
"
>)" G(&K)%" " H:anjD<De%?" L6+3+$/" .)" 011m" B" 01!!" G3(" 53" :/;6&+"
H)+%()?" /%36%" $&&(.&++/" G3(" %(&67"/J46G)7"&(5/3+367)7F" @)4N" .)"
'6&5&;6)" OHhj?" H]:C" i<:" \81!Q" .6(6;/)7" ()7G)$%6,)-)+%" G3(" ["
C$I&)+%;)+")%"k"h/+/.)%%6")%"4+)".)"$I6-6)?"C":&4%6)("OaH#D?"ij:"
H]:C"V8!!QF">)7"&'K)$%6L7".)"$)"G(&;(3--)"/%36)+%"T"
08Q .)" $&+7%6%4)(" 4+" G53%)34" .)" %)7%7" '6&5&;6J4)7" G&4(" .&7)("
5Y3$%6,6%/" .)7" G(&%/6+)7" e6+37)7" .)7" ,&6)7" jD<" e6+37)7"
:3LSj^nS^:n"G467"<a8nSDnlS-l#:?" $)7",&6)7"+Y/%3+%"G547"
(/;45/)7".3+7".)"+&-'()4N"$3+$)(7?"
0\Q .)" ./,)5&GG)(" .)7" -&5/$45)7" $3G3'5)7" .Y6+I6')(" 5)7"
)+M=-)7".)"$)7".)4N",&6)7".)"76;+35673%6&+F"
Tests*biologiques""
>)7" /%4.)7" .)" 53" ,&6)" :3LSj^nS^:n?" 5)7" %)7%7" -67" 34" G&6+%" )%" 5)7"
6+I6'6%)4(7" .)" :D[" 7=+%I/%67/7" &+%" L36%" 5Y&'K)%" .Y4+" 3(%6$5)" .3+7" 53"
5)%%()".Y6+L&(-3%6&+".)"5Y3N)"W"K3+,6)(*L/,(6)("01!1"X?"$)%%)"G3(%6)".4"
G(&K)%"+)"7)(3".&+$"G37"./,)5&GG/)".)"+&4,)34F"
>3" ,&6)" <a8nSDe%S-l#:" )7%" 4+)" ,&6)" .)" 76;+35673%6&+" 74(3$%6,/)"
.3+7" .)" +&-'()4N" $3+$)(7F" C3" 74(3$%6,3%6&+" )7%" 4+" L3$%)4(" .)"
(/767%3+$)"B"53"$I6-6&%I/(3G6)".3+7"$)(%36+7"$3+$)(7F""
<a8n" )7%" 3$%6,/)" G3(" .)7" (/$)G%)4(7" B" %=(&76+)" e6+37)" )%" .)7"
(/$)G%)4(7" $&4G5/7" 34N" G(&%/6+)7" EF" i+)" L&67" 3$%6,/)?" <a8n" ,3"
GI&7GI&(=5)(" 4+" GI&7GI&56G6.)" -)-'(3+36()" 5)" <a<0" )+" <a<8F" H)"
.)(+6)(" 3" .)" 5Y3LL6+6%/" G&4(" .)7" .&-36+)7" <k" OG5)$e7%(6+"
I&-&5&;&47".&-36+Q".)7"e6+37)7"De%")%"<@n!")%",3"5)7"()$(4%)("B"53"
-)-'(3+)F"De%",3"="P%()"GI&7GI&(=5/)")%"3$%6,/)F"i+)"L&67"3$%6,/)?"
)55)",3"G&4,&6("GI&7GI&(=5)("4+";(3+."+&-'()".)"$6'5)7"$)554536()7"
6-G56J4/)7" .3+7" .6LL/()+%7" G(&$)7747" %)57" J4)" 5Y3+;6&;)+A7)?" 53"
G(&;()776&+" .4" $=$5)" $)554536()?" 53" 74(,6)" $)554536()?" 53"7=+%IA7)" .)"
;5=$&;A+)")%"53"$(&6773+$)"$)554536()"!"#"53"e6+37)"-l#:"34"7)6+".4"
$&-G5)N)"-l#:H!F"
@)7"6+I6'6%)4(7".)"-l#:")%".YDe%"&+%"./KB"/%/"./,)5&GG/7")%"%)7%/7"
)+" )77367" $56+6J4)7".)" GI37)" a?" aa" )%" aaaF" ^N$)G%/" .3+7" 5)" $37" .4"
$3($6+&-)" (/+35?" 65" 3GG3(3o%" J4)" $)7" 6+I6'6%)4(7" &+%" .)7" )LL)%7"
./$),3+%7F"H)7"(/745%3%7"&+%"/%/"(/$)--)+%"$&-G(67"4+)"L&67"J4)"53"
,&6)"De%"36%"/%/"-6)4N"/%4.6/)F"@Y4+)"G3(%?"5)7".)4N"e6+37)7"De%")%"
-l#:"G)4,)+%"P%()"$&4($6($46%/)7"G3("5)"L36%"J4)"<@n!")7%"$3G3'5)"
.Y3$%6,)(".6()$%)-)+%"53"C9e6+37)F"@Y34%()"G3(%?"65")N67%)"4+)",&6)".)"
(/%(&$&+%(Z5)" .)" 5Y3$%6,3%6&+" .)" <a8n" G3(" -l#:F" D6+76?" 5&(7J4)"
-l#:")7%"6+I6'/)?"<a8n"+)"G)4%"G547"5YP%()F"D5&(7?"<a8n",3"P%()"G547"
3$%6,/)")%"B"%)(-)?"4+")LL)%"()'&+.".)"5Y3$%6,3%6&+".)"53",&6)")%".&+$"
.YDe%" )%" .)" -l#:" 7)" G(&.46%F" a5" 3GG3(3o%" J4)" 76" 5Y&+" ,)4%" 6+I6')("
)LL6$3$)-)+%"53",&6)?"53"e6+37)"J4Y65"L34%"$6'5)(")7%"53"G()-6A()".)"53"
,&6)" <a8n" -367" -l#:" G)4%*P%()" 3$%6,/)" 6+./G)+.3--)+%" .)" <a8n"
,63"+&%3--)+%"53",&6)":3LSj^nS^:nF""
"
H)%%)" 7%(3%/;6)" )7%" .Y34%3+%" G547" (/3567%)" J4)" <a8n" )%" -l#:"
3GG3(%6)++)+%" B" 53" -P-)" L3-655)" .)" e6+37)7" )%" J4)" .)" %(A7" '&+7"
6+I6'6%)4(7".&4'5)7"G)4,)+%"P%()"./,)5&GG/7F""
"
La*soutenance*de*thèse*de*Maxime*Guéguinou*–*14*décembre*2015*à*Tours
i+" $&-G5)N)" .6LL/()+%" .)" $)546" &'7)(,/" .3+7"
5)7"$)5545)7".)"$3+$)(".4"7)6+")%".4"$&5&+"3"/%/"./$(6%".3+7".)7"
$)5545)7" $3+$/()47)7" G(&7%3%6J4)7F" a5" 7Y3;6%" .Y4+" $&-G5)N)"
Cn8SClaj!S#(360" (/;453+%" 4+)" )+%(/)" $35$6J4)" .)" %=G)" C#H^"
)77)+%6)55)" B" 53"-6;(3%6&+" $)554536()" 73+7" 3LL)$%)(" 53"
G(&56L/(3%6&+F" D6+76?" 65" G&4((36%" )N67%)(" 4+)" ()53%6&+" )+%()"53"
+3%4()" .)" $)7" $&-G5)N)7" )%" 5)" %(&G67-)" -/%37%3%6J4)" .)"
.6LL/()+%7" $3+$)(7"T" .3+7" 5)" $3+$)(" .4" 7)6+?" 35&(7" J4)" 5)"
$&-G5)N)" #(36!SCn8" (/;45)" 4+)" )+%(/)" $&+7%6%4%6,)" .)" H30w"
L3,&(673+%" 5)" ./,)5&GG)-)+%" .)" -/%37%37)7" &77)47)7?" 5)7"
$&-G5)N)7" l:<S#(36SClaj!" 377&$6/7" B" Cn8" (/;45)(36)+%" 4+)"
)+%(/)" C#H^" L3,&(673+%" 5)" ./,)5&GG)-)+%" .)" -/%37%37)7"
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G(&7%3%6J4)FH)" %(3,365" )7%" 5)" L(46%" .Y4+)" $&553'&(3%6&+" /%(&6%)"
)+%()"5)7" '6&5&;67%)7?"5)7" "$56+6$6)+7" )%" 5)7"$I6-67%)7" .4"(/7)34"
H3+34N"6&+6J4)7")%"$3+$)(F""
"
D4"$&4(7"73"%IA7)?"j3N6-)"3"&'%)+4"4+)"'&4(7)".)"$&+;(A7".)"
5Y3N)" `35&(673%6&+" .)7" G(&.46%7" .)" 53" -)(" )+" $3+$/(&5&;6)" 546"
G)(-)%%3+%" .)" G3(%6$6G)(" B" 4+" $&+;(A7" .4" E(&4G)" @)"
:)$I)($I)" ^4(&G/)+?" 5)" E@:^" H]:C" S^4(&G)3+" H35$64-"
C&$6)%=F"C)7"%(3,34N"&+%"/%/"(/$&-G)+7/7"G3("4+"G(6N"G&7%)(".)"
>6;4)" ]3%6&+35)" $&+%()" 5)" $3+$)(" 34N" U&4(+/)7" :)$I)($I)"
l&4(7*<&6%6)(7*>6-&;)7"01!\")%""&+%"/%/"7/5)$%6&++/7"G&4("4+)"
G(/7)+%3%6&+" &(35)" .3+7" 5)" $3.()" .)7" 7)776&+7" K)4+)7"
$I)($I)4(7" .)7" qA-)7" K&4(+/)7" .4"H3+$/(&GZ5)"E(3+." #4)7%"
34N" C3'5)7" .Y#5&++)"T" W"H&-G5)N)" $3+3536()" Cn8S#(36!Sl:<H!"
.3+7" 53" -6;(3%6&+" .)7" $)5545)7" $3+$/()47)7" $&56J4)7"kHl!!9"
T")LL)%".4"H/%4N6-3'")%",&6)"DnlS:3$"XF"
"
>)"K4(=".)"%IA7)"/%36%")+"G3(%6)"$&-G&7/"G3(".)7"-)-'()7".4"
:/7)34T" #56,6)(" j6;+)+" Oh()7%Q?" h(4+&" H&+7%3+%6+" O<&6%6)(7Q?"
lI6)((=" >)$&-%)" Ol&4(7Q?"HI(67%&GI)" `3+.6)(" )%" j3(6)" <&%6)(*
H3(%)()34"Ol&4(7QF"
"
j3N6-)"E4/;46+&4" 3" G3(" 3655)4(7" &'%)+4" 4+" G&7%*.&$%&(3%" B"
<)++"C%3%)"i+6,)(76%=?"H&55);)"&L"j).6$6+)?"k)(7I)="$I)M"5)"<(F"
j&I3-)."l()'3e?"@G%"&L"H)55453("3+."-&5)$453("GI=76&5&;=F"
"
Publications*
*"E4/;46+&4"j")%"35?"#+$&%3(;)%?")+"(/,676&+"L3,&(3'5)"
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*" C),(36+" Hj?" k3)5%)(7" U<?" HI3+%Z-)" D?" H&4%I&+*E&4(,A7" k?" E4);46+&4" j?"
<&%6)(*H3(%)()34" j?" `3+.6)(" H?" U3LL(A7" <DF" #(;" h6&-&5" HI)-F" @6E353$%&7=5*
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:.88+8.4-:#1:D'.+4.4-:&8"T+.4/-

2
Responsable*de*l’axe*Valorisation*des*produits*de*la*mer:*Pr*Sylvain*Routier*
sylvain.routier@univ;orleans.fr*;*02*38*49*48*53*
Responsable*du*Réseau*Canaux*ioniques*et*cancer*:*Pr*Christophe*Vandier*
christophe.vandier@univ;tours.fr*;*02*47*36*60*24*
* *
"
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"
!
Actualités*
"
!A*vos*agendas."^+"01!\?"5_3N)"`35&(673%6&+".)7"G(&.46%7".)"53"-)("LP%)(3"7)7"!1"3+7"._)N67%)+$)F"
<&4("-3(J4)("5_/,/+)-)+%?"5)"$&55&J4)".)"5_3N)"$I3+;)(3"J4)5J4)"G)4".)"L&(-3%")%".)"56)4F"
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Dans*l’attente*des*prochains*dossiers…*
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)+M=-)7".)"$)7".)4N",&6)7".)"76;+35673%6&+F"
Tests*biologiques""
>)7" /%4.)7" .)" 53" ,&6)" :3LSj^nS^:n?" 5)7" %)7%7" -67" 34" G&6+%" )%" 5)7"
6+I6'6%)4(7" .)" :D[" 7=+%I/%67/7" &+%" L36%" 5Y&'K)%" .Y4+" 3(%6$5)" .3+7" 53"
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Tests*biologiques""
>)7" /%4.)7" .)" 53" ,&6)" :3LSj^nS^:n?" 5)7" %)7%7" -67" 34" G&6+%" )%" 5)7"
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Tests*biologiques""
>)7" /%4.)7" .)" 53" ,&6)" :3LSj^nS^:n?" 5)7" %)7%7" -67" 34" G&6+%" )%" 5)7"
6+I6'6%)4(7" .)" :D[" 7=+%I/%67/7" &+%" L36%" 5Y&'K)%" .Y4+" 3(%6$5)" .3+7" 53"
5)%%()".Y6+L&(-3%6&+".)"5Y3N)"W"K3+,6)(*L/,(6)("01!1"X?"$)%%)"G3(%6)".4"
G(&K)%"+)"7)(3".&+$"G37"./,)5&GG/)".)"+&4,)34F"
>3" ,&6)" <a8nSDe%S-l#:" )7%" 4+)" ,&6)" .)" 76;+35673%6&+" 74(3$%6,/)"
.3+7" .)" +&-'()4N" $3+$)(7F" C3" 74(3$%6,3%6&+" )7%" 4+" L3$%)4(" .)"
(/767%3+$)"B"53"$I6-6&%I/(3G6)".3+7"$)(%36+7"$3+$)(7F""
<a8n" )7%" 3$%6,/)" G3(" .)7" (/$)G%)4(7" B" %=(&76+)" e6+37)" )%" .)7"
(/$)G%)4(7" $&4G5/7" 34N" G(&%/6+)7" EF" i+)" L&67" 3$%6,/)?" <a8n" ,3"
GI&7GI&(=5)(" 4+" GI&7GI&56G6.)" -)-'(3+36()" 5)" <a<0" )+" <a<8F" H)"
.)(+6)(" 3" .)" 5Y3LL6+6%/" G&4(" .)7" .&-36+)7" <k" OG5)$e7%(6+"
I&-&5&;&47".&-36+Q".)7"e6+37)7"De%")%"<@n!")%",3"5)7"()$(4%)("B"53"
-)-'(3+)F"De%",3"="P%()"GI&7GI&(=5/)")%"3$%6,/)F"i+)"L&67"3$%6,/)?"
)55)",3"G&4,&6("GI&7GI&(=5)("4+";(3+."+&-'()".)"$6'5)7"$)554536()7"
6-G56J4/)7" .3+7" .6LL/()+%7" G(&$)7747" %)57" J4)" 5Y3+;6&;)+A7)?" 53"
G(&;()776&+" .4" $=$5)" $)554536()?" 53" 74(,6)" $)554536()?" 53"7=+%IA7)" .)"
;5=$&;A+)")%"53"$(&6773+$)"$)554536()"!"#"53"e6+37)"-l#:"34"7)6+".4"
$&-G5)N)"-l#:H!F"
@)7"6+I6'6%)4(7".)"-l#:")%".YDe%"&+%"./KB"/%/"./,)5&GG/7")%"%)7%/7"
)+" )77367" $56+6J4)7" .)" GI37)" a?" aa" )%" aaaF" ^N$)G%/" .3+7" 5)" $37" .4"
$3($6+&-)" (/+35?" 65" 3GG3(3o%" J4)" $)7" 6+I6'6%)4(7" &+%" .)7" )LL)%7"
./$),3+%7F"H)7"(/745%3%7"&+%"/%/"(/$)--)+%"$&-G(67"4+)"L&67"J4)"53"
,&6)"De%"36%"/%/"-6)4N"/%4.6/)F"@Y4+)"G3(%?"5)7".)4N"e6+37)7"De%")%"
-l#:"G)4,)+%"P%()"$&4($6($46%/)7"G3("5)"L36%"J4)"<@n!")7%"$3G3'5)"
.Y3$%6,)(".6()$%)-)+%"53"C9e6+37)F"@Y34%()"G3(%?"65")N67%)"4+)",&6)".)"
(/%(&$&+%(Z5)" .)" 5Y3$%6,3%6&+" .)" <a8n" G3(" -l#:F" D6+76?" 5&(7J4)"
-l#:")7%"6+I6'/)?"<a8n"+)"G)4%"G547"5YP%()F"D5&(7?"<a8n",3"P%()"G547"
3$%6,/)")%"B"%)(-)?"4+")LL)%"()'&+.".)"5Y3$%6,3%6&+".)"53",&6)")%".&+$"
.YDe%" )%" .)" -l#:" 7)" G(&.46%F" a5" 3GG3(3o%" J4)" 76" 5Y&+" ,)4%" 6+I6')("
)LL6$3$)-)+%"53",&6)?"53"e6+37)"J4Y65"L34%"$6'5)(")7%"53"G()-6A()".)"53"
,&6)" <a8n" -367" -l#:" G)4%*P%()" 3$%6,/)" 6+./G)+.3--)+%" .)" <a8n"
,63"+&%3--)+%"53",&6)":3LSj^nS^:nF""
"
H)%%)" 7%(3%/;6)" )7%" .Y34%3+%" G547" (/3567%)" J4)" <a8n" )%" -l#:"
3GG3(%6)++)+%" B" 53" -P-)" L3-655)" .)" e6+37)7" )%" J4)" .)" %(A7" '&+7"
6+I6'6%)4(7".&4'5)7"G)4,)+%"P%()"./,)5&GG/7F""
"
"
"
"
"
>)" G(&K)%" " H:anjD<De%?" L6+3+$/" .)" 011m" B" 01!!" G3(" 53" :/;6&+"
H)+%()?" /%36%" $&&(.&++/" G3(" %(&67"/J46G)7"&(5/3+367)7F" @)4N" .)"
'6&5&;6)" OHhj?" H]:C" i<:" \81!Q" .6(6;/)7" ()7G)$%6,)-)+%" G3(" ["
C$I&)+%;)+")%"k"h/+/.)%%6")%"4+)".)"$I6-6)?"C":&4%6)("OaH#D?"ij:"
H]:C"V8!!QF">)7"&'K)$%6L7".)"$)"G(&;(3--)"/%36)+%"T"
8!Q .)" $&+7%6%4)(" 4+" G53%)34" .)" %)7%7" '6&5&;6J4)7" G&4(" .&7)("
5Y3$%6,6%/" .)7" G(&%/6+)7" e6+37)7" .)7" ,&6)7" jD<" e6+37)7"
:3LSj^nS^:n"G467"<a8nSDnlS-l#:?" $)7",&6)7"+Y/%3+%"G547"
(/;45/)7".3+7".)"+&-'()4N"$3+$)(7?"
80Q .)" ./,)5&GG)(" .)7" -&5/$45)7" $3G3'5)7" .Y6+I6')(" 5)7"
)+M=-)7".)"$)7".)4N",&6)7".)"76;+35673%6&+F"
Tests*biologiques""
>)7" /%4.)7" .)" 53" ,&6)" :3LSj^nS^:n?" 5)7" %)7%7" -67" 34" G&6+%" )%" 5)7"
6+I6'6%)4(7" .)" :D[" 7=+%I/%67/7" &+%" L36%" 5Y&'K)%" .Y4+" 3(%6$5)" .3+7" 53"
5)%%()".Y6+L&(-3%6&+".)"5Y3N)"W"K3+,6)(*L/,(6)("01!1"X?"$)%%)"G3(%6)".4"
G(&K)%"+)"7)(3".&+$"G37"./,)5&GG/)".)"+&4,)34F"
>3" ,&6)" <a8nSDe%S-l#:" )7%" 4+)" ,&6)" .)" 76;+35673%6&+" 74(3$%6,/)"
.3+7" .)" +&-'()4N" $3+$)(7F" C3" 74(3$%6,3%6&+" )7%" 4+" L3$%)4(" .)"
(/767%3+$)"B"53"$I6-6&%I/(3G6)".3+7"$)(%36+7"$3+$)(7F""
<a8n" )7%" 3$%6,/)" G3(" .)7" (/$)G%)4(7" B" %=(&76+)" e6+37)" )%" .)7"
(/$)G%)4(7" $&4G5/7" 34N" G(&%/6+)7" EF" i+)" L&67" 3$%6,/)?" <a8n" ,3"
GI&7GI&(=5)(" 4+" GI&7GI&56G6.)" -)-'(3+36()" 5)" <a<0" )+" <a<8F" H)"
.)(+6)(" 3" .)" 5Y3LL6+6%/" G&4(".)7" .&-36+)7" <k" OG5)$e7%(6+"
I&-&5&;&47".&-36+Q".)7"e6+37)7"De%")%"<@n!")%",3"5)7"()$(4%)("B"53"
-)-'(3+)F"De%",3"="P%()"GI&7GI&(=5/)")%"3$%6,/)F"i+)"L&67"3$%6,/)?"
)55)",3"G&4,&6("GI&7GI&(=5)("4+";(3+."+&-'()".)"$6'5)7"$)554536()7"
6-G56J4/)7" .3+7" .6LL/()+%7"G(&$)7747" %)57" J4)" 5Y3+;6&;)+A7)?" 53"
G(&;()776&+" .4" $=$5)" $)554536()?" 53" 74(,6)" $)554536()?" 53"7=+%IA7)" .)"
;5=$&;A+)")%"53"$(&6773+$)"$)554536()"!"#"53"e6+37)"-l#:"34"7)6+".4"
$&-G5)N)"-l#:H!F"
@)7"6+I6'6%)4(7".)"-l#:")%".YDe%"&+%"./KB"/%/"./,)5&GG/7")%"%)7%/7"
)+" )77367" $56+6J4)7" .)" GI37)" a?" aa" )%" aaaF" ^N$)G%/" .3+7" 5)" $37" .4"
$3($6+&-)" (/+35?" 65" 3GG3(3o%" J4)" $)7" 6+I6'6%)4(7" &+%" .)7" )LL)%7"
./$),3+%7F"H)7"(/745%3%7"&+%"/%/"(/$)--)+%"$&-G(67"4+)"L&67"J4)"53"
,&6)"De%"36%"/%/"-6)4N"/%4.6/)F"@Y4+)"G3(%?"5)7".)4N"e6+37)7"De%")%"
-l#:"G)4,)+%"P%()"$&4($6($46%/)7"G3("5)"L36%"J4)"<@n!")7%"$3G3'5)"
.Y3$%6,)(".6()$%)-)+%"53"C9e6+37)F"@Y34%()"G3(%?"65")N67%)"4+)",&6)".)"
(/%(&$&+%(Z5)" .)" 5Y3$%6,3%6&+" .)" <a8n" G3(" -l#:F" D6+76?" 5&(7J4)"
-l#:")7%"6+I6'/)?"<a8n"+)"G)4%"G547"5YP%()F"D5&(7?"<a8n",3"P%()"G547"
3$%6,/)")%"B"%)(-)?"4+")LL)%"()'&+.".)"5Y3$%6,3%6&+".)"53",&6)")%".&+$"
.YDe%" )%" .)" -l#:" 7)" G(&.46%F" a5" 3GG3(3o%" J4)" 76" 5Y&+" ,)4%" 6+I6')("
)LL6$3$)-)+%"53",&6)?"53"e6+37)"J4Y65"L34%"$6'5)(")7%"53"G()-6A()".)"53"
,&6)" <a8n" -367" -l#:" G)4%*P%()" 3$%6,/)" 6+./G)+.3--)+%" .)" <a8n"
,63"+&%3--)+%"53",&6)":3LSj^nS^:nF""
"
H)%%)" 7%(3%/;6)" )7%" .Y34%3+%" G547" (/3567%)" J4)" <a8n" )%" -l#:"
3GG3(%6)++)+%" B" 53" -P-)" L3-655)" .)" e6+37)7" )%" J4)" .)" %(A7" '&+7"
6+I6'6%)4(7".&4'5)7"G)4,)+%"P%()"./,)5&GG/7F""
"
"
"
"
>)" G(&K)%" " H:anjD<De%?" L6+3+$/" .)" 011m" B" 01!!" G3(" 53" :/;6&+"
H)+%()?" /%36%" $&&(.&++/" G3(" %(&67"/J46G)7"&(5/3+367)7F" @)4N" .)"
'6&5&;6)" OHhj?" H]:C" i<:" \81!Q" .6(6;/)7" ()7G)$%6,)-)+%" G3(" ["
C$I&)+%;)+")%"k"h/+/.)%%6")%"4+)".)"$I6-6)?"C":&4%6)("OaH#D?"ij:"
H]:C"V8!!QF">)7"&'K)$%6L7".)"$)"G(&;(3--)"/%36)+%"T"
88Q .)" $&+7%6%4)(" 4+" G53%)34" .)" %)7%7" '6&5&;6J4)7" G&4(" .&7)("
5Y3$%6,6%/" .)7" G(&%/6+)7" e6+37)7" .)7" ,&6)7" jD<" e6+37)7"
:3LSj^nS^:n"G467"<a8nSDnlS-l#:?" $)7",&6)7"+Y/%3+%"G547"
(/;45/)7".3+7".)"+&-'()4N"$3+$)(7?"
8\Q .)" ./,)5&GG)(" .)7" -&5/$45)7" $3G3'5)7" .Y6+I6')(" 5)7"
)+M=-)7".)"$)7".)4N",&6)7".)"76;+35673%6&+F"
Tests*biologiques""
>)7" /%4.)7" .)" 53" ,&6)" :3LSj^nS^:n?" 5)7" %)7%7" -67" 34" G&6+%" )%" 5)7"
6+I6'6%)4(7" .)" :D[" 7=+%I/%67/7" &+%" L36%" 5Y&'K)%" .Y4+" 3(%6$5)" .3+7" 53"
5)%%()".Y6+L&(-3%6&+".)"5Y3N)"W"K3+,6)(*L/,(6)("01!1"X?"$)%%)"G3(%6)".4"
G(&K)%"+)"7)(3".&+$"G37"./,)5&GG/)".)"+&4,)34F"
>3" ,&6)" <a8nSDe%S-l#:" )7%" 4+)" ,&6)" .)" 76;+35673%6&+" 74(3$%6,/)"
.3+7" .)" +&-'()4N" $3+$)(7F" C3" 74(3$%6,3%6&+" )7%" 4+" L3$%)4(" .)"
(/767%3+$)"B"53"$I6-6&%I/(3G6)".3+7"$)(%36+7"$3+$)(7F""
<a8n" )7%" 3$%6,/)" G3(" .)7" (/$)G%)4(7" B" %=(&76+)" e6+37)" )%" .)7"
(/$)G%)4(7" $&4G5/7" 34N" G(&%/6+)7" EF" i+)" L&67" 3$%6,/)?" <a8n" ,3"
GI&7GI&(=5)(" 4+" GI&7GI&56G6.)" -)-'(3+36()" 5)" <a<0" )+" <a<8F" H)"
.)(+6)(" 3" .)" 5Y3LL6+6%/" G&4(" .)7" .&-36+)7" <k" OG5)$e7%(6+"
I&-&5&;&47".&-36+Q".)7"e6+37)7"De%")%"<@n!")%",3"5)7"()$(4%)("B"53"
-)-'(3+)F"De%",3"="P%()"GI&7GI&(=5/)")%"3$%6,/)F"i+)"L&67"3$%6,/)?"
)55)",3"G&4,&6("GI&7GI&(=5)("4+";(3+."+&-'()".)"$6'5)7"$)554536()7"
6-G56J4/)7" .3+7" .6LL/()+%7" G(&$)7747" %)57" J4)" 5Y3+;6&;)+A7)?" 53"
G(&;()776&+" .4" $=$5)" $)554536()?" 53" 74(,6)" $)554536()?" 53"7=+%IA7)" .)"
;5=$&;A+)")%"53"$(&6773+$)"$)554536()"!"#"53"e6+37)"-l#:"34"7)6+".4"
$&-G5)N)"-l#:H!F"
@)7"6+I6'6%)4(7".)"-l#:")%".YDe%"&+%"./KB"/%/"./,)5&GG/7")%"%)7%/7"
)+" )77367" $56+6J4)7" .)" GI37)" a?" aa" )%" aaaF" ^N$)G%/" .3+7" 5)" $37" .4"
$3($6+&-)" (/+35?" 65" 3GG3(3o%" J4)" $)7" 6+I6'6%)4(7" &+%" .)7" )LL)%7"
./$),3+%7F"H)7"(/745%3%7"&+%"/%/"(/$)--)+%"$&-G(67"4+)"L&67"J4)"53"
,&6)"De%"36%"/%/"-6)4N"/%4.6/)F"@Y4+)"G3(%?"5)7".)4N"e6+37)7"De%")%"
-l#:"G)4,)+%"P%()"$&4($6($46%/)7"G3("5)"L36%"J4)"<@n!")7%"$3G3'5)"
.Y3$%6,)(".6()$%)-)+%"53"C9e6+37)F"@Y34%()"G3(%?"65")N67%)"4+)",&6)".)"
(/%(&$&+%(Z5)" .)" 5Y3$%6,3%6&+" .)" <a8n" G3(" -l#:F" D6+76?" 5&(7J4)"
-l#:")7%"6+I6'/)?"<a8n"+)"G)4%"G547"5YP%()F"D5&(7?"<a8n",3"P%()"G547"
3$%6,/)")%"B"%)(-)?"4+")LL)%"()'&+.".)"5Y3$%6,3%6&+".)"53",&6)")%".&+$"
.YDe%" )%" .)" -l#:" 7)" G(&.46%F" a5" 3GG3(3o%" J4)" 76" 5Y&+" ,)4%" 6+I6')("
)LL6$3$)-)+%"53",&6)?"53"e6+37)"J4Y65"L34%"$6'5)(")7%"53"G()-6A()".)"53"
,&6)" <a8n" -367" -l#:" G)4%*P%()" 3$%6,/)" 6+./G)+.3--)+%".)" <a8n"
,63"+&%3--)+%"53",&6)":3LSj^nS^:nF""
"
H)%%)" 7%(3%/;6)" )7%" .Y34%3+%" G547" (/3567%)" J4)" <a8n" )%" -l#:"
3GG3(%6)++)+%" B" 53" -P-)" L3-655)" .)" e6+37)7" )%" J4)" .)" %(A7" '&+7"
6+I6'6%)4(7".&4'5)7"G)4,)+%"P%()"./,)5&GG/7F""
"
"
"
"
>)" G(&K)%" " H:anjD<De%?" L6+3+$/" .)" 011m" B" 01!!" G3(" 53" :/;6&+"
H)+%()?" /%36%" $&&(.&++/" G3(" %(&67"/J46G)7"&(5/3+367)7F" @)4N" .)"
'6&5&;6)" OHhj?" H]:C" i<:" \81!Q" .6(6;/)7" ()7G)$%6,)-)+%" G3(" ["
C$I&)+%;)+")%"k"h/+/.)%%6")%"4+)".)"$I6-6)?"C":&4%6)("OaH#D?"ij:"
H]:C"V8!!QF">)7"&'K)$%6L7".)"$)"G(&;(3--)"/%36)+%"T"
82Q .)" $&+7%6%4)(" 4+" G53%)34" .)" %)7%7" '6&5&;6J4)7" G&4(" .&7)("
5Y3$%6,6%/" .)7" G(&%/6+)7" e6+37)7" .)7" ,&6)7" jD<" e6+37)7"
:3LSj^nS^:n"G467"<a8nSDnlS-l#:?" $)7",&6)7"+Y/%3+%"G547"
(/;45/)7".3+7".)"+&-'()4N"$3+$)(7?"
89Q .)" ./,)5&GG)(" .)7" -&5/$45)7" $3G3'5)7" .Y6+I6')(" 5)7"
)+M=-)7".)"$)7".)4N",&6)7".)"76;+35673%6&+F"
Tests*biologiques""
>)7" /%4.)7" .)" 53" ,&6)" :3LSj^nS^:n?" 5)7" %)7%7" -67" 34" G&6+%" )%" 5)7"
6+I6'6%)4(7" .)" :D[" 7=+%I/%67/7" &+%" L36%" 5Y&'K)%" .Y4+" 3(%6$5)" .3+7" 53"
5)%%()".Y6+L&(-3%6&+".)"5Y3N)"W"K3+,6)(*L/,(6)("01!1"X?"$)%%)"G3(%6)".4"
G(&K)%"+)"7)(3".&+$"G37"./,)5&GG/)".)"+&4,)34F"
>3" ,&6)" <a8nSDe%S-l#:" )7%" 4+)" ,&6)" .)" 76;+35673%6&+" 74(3$%6,/)"
.3+7" .)" +&-'()4N" $3+$)(7F" C3" 74(3$%6,3%6&+" )7%" 4+" L3$%)4(" .)"
(/767%3+$)"B"53"$I6-6&%I/(3G6)".3+7"$)(%36+7"$3+$)(7F""
<a8n" )7%" 3$%6,/)" G3(" .)7" (/$)G%)4(7" B" %=(&76+)" e6+37)" )%" .)7"
(/$)G%)4(7" $&4G5/7" 34N" G(&%/6+)7" EF" i+)" L&67" 3$%6,/)?" <a8n" ,3"
GI&7GI&(=5)(" 4+" GI&7GI&56G6.)" -)-'(3+36()" 5)" <a<0" )+" <a<8F" H)"
.)(+6)(" 3" .)" 5Y3LL6+6%/" G&4(" .)7" .&-36+)7" <k" OG5)$e7%(6+"
I&-&5&;&47".&-36+Q".)7"e6+37)7"De%")%"<@n!")%",3"5)7"()$(4%)("B"53"
-)-'(3+)F"De%",3"="P%()"GI&7GI&(=5/)")%"3$%6,/)F"i+)"L&67"3$%6,/)?"
)55)",3"G&4,&6("GI&7GI&(=5)("4+";(3+."+&-'()".)"$6'5)7"$)554536()7"
6-G56J4/)7" .3+7" .6LL/()+%7" G(&$)7747" %)57" J4)" 5Y3+;6&;)+A7)?" 53"
G(&;()776&+" .4" $=$5)"$)554536()?" 53" 74(,6)" $)554536()?" 53" 7=+%IA7)" .)"
;5=$&;A+)")%"53"$(&6773+$)"$)554536()"!"#"53"e6+37)"-l#:"34"7)6+".4"
$&-G5)N)"-l#:H!F"
@)7"6+I6'6%)4(7".)"-l#:")%".YDe%"&+%"./KB"/%/"./,)5&GG/7")%"%)7%/7"
)+" )77367" $56+6J4)7" .)" GI37)" a?" aa" )%"aaaF" ^N$)G%/" .3+7" 5)" $37" .4"
$3($6+&-)" (/+35?" 65" 3GG3(3o%" J4)" $)7" 6+I6'6%)4(7" &+%" .)7" )LL)%7"
./$),3+%7F"H)7"(/745%3%7"&+%"/%/"(/$)--)+%"$&-G(67"4+)"L&67"J4)"53"
,&6)"De%"36%"/%/"-6)4N"/%4.6/)F"@Y4+)"G3(%?"5)7".)4N"e6+37)7"De%")%"
-l#:"G)4,)+%"P%()"$&4($6($46%/)7"G3("5)"L36%"J4)"<@n!")7%"$3G3'5)"
.Y3$%6,)(".6()$%)-)+%"53"C9e6+37)F"@Y34%()"G3(%?"65")N67%)"4+)",&6)".)"
(/%(&$&+%(Z5)" .)" 5Y3$%6,3%6&+" .)" <a8n" G3(" -l#:F" D6+76?" 5&(7J4)"
-l#:")7%"6+I6'/)?"<a8n"+)"G)4%"G547"5YP%()F"D5&(7?"<a8n",3"P%()"G547"
3$%6,/)")%"B"%)(-)?"4+")LL)%"()'&+.".)"5Y3$%6,3%6&+".)"53",&6)")%".&+$"
.YDe%" )%" .)" -l#:" 7)" G(&.46%F" a5" 3GG3(3o%" J4)" 76" 5Y&+" ,)4%" 6+I6')("
)LL6$3$)-)+%"53",&6)?"53"e6+37)"J4Y65"L34%"$6'5)(")7%"53"G()-6A()".)"53"
,&6)" <a8n" -367" -l#:" G)4%*P%()" 3$%6,/)" 6+./G)+.3--)+%" .)" <a8n"
,63"+&%3--)+%"53",&6)":3LSj^nS^:nF""
"
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"
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"
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"
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""
D"5_6774".4"$&+;(A7?"5)".&$%&(3+%"7)(3"7&556$6%/"G&4(T"
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"
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"
Dans*l’attente*des*prochains*dossiers…*
"
"
"
>)" G(&K)%" " H:anjD<De%?" L6+3+$/" .)" 011m" B" 01!!" G3(" 53" :/;6&+"
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'6&5&;6)" OHhj?" H]:C" i<:" \81!Q" .6(6;/)7" ()7G)$%6,)-)+%" G3(" ["
C$I&)+%;)+")%"k"h/+/.)%%6")%"4+)".)"$I6-6)?"C":&4%6)("OaH#D?"ij:"
H]:C"V8!!QF">)7"&'K)$%6L7".)"$)"G(&;(3--)"/%36)+%"T"
8VQ .)" $&+7%6%4)(" 4+" G53%)34" .)" %)7%7" '6&5&;6J4)7" G&4(" .&7)("
5Y3$%6,6%/" .)7" G(&%/6+)7" e6+37)7" .)7" ,&6)7" jD<" e6+37)7"
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8qQ .)" ./,)5&GG)(" .)7" -&5/$45)7" $3G3'5)7" .Y6+I6')(" 5)7"
)+M=-)7".)"$)7".)4N",&6)7".)"76;+35673%6&+F"
Tests*biologiques""
>)7" /%4.)7" .)" 53" ,&6)" :3LSj^nS^:n?" 5)7" %)7%7" -67" 34" G&6+%" )%" 5)7"
6+I6'6%)4(7" .)" :D[" 7=+%I/%67/7" &+%" L36%" 5Y&'K)%" .Y4+" 3(%6$5)" .3+7" 53"
5)%%()".Y6+L&(-3%6&+".)"5Y3N)"W"K3+,6)(*L/,(6)("01!1"X?"$)%%)"G3(%6)".4"
G(&K)%"+)"7)(3".&+$"G37"./,)5&GG/)".)"+&4,)34F"
>3" ,&6)" <a8nSDe%S-l#:" )7%" 4+)" ,&6)" .)" 76;+35673%6&+" 74(3$%6,/)"
.3+7" .)" +&-'()4N" $3+$)(7F" C3" 74(3$%6,3%6&+" )7%" 4+" L3$%)4(" .)"
(/767%3+$)"B"53"$I6-6&%I/(3G6)".3+7"$)(%36+7"$3+$)(7F""
<a8n" )7%" 3$%6,/)" G3(" .)7" (/$)G%)4(7" B" %=(&76+)" e6+37)" )%" .)7"
(/$)G%)4(7" $&4G5/7" 34N" G(&%/6+)7" EF" i+)" L&67" 3$%6,/)?" <a8n" ,3"
GI&7GI&(=5)(" 4+" GI&7GI&56G6.)" -)-'(3+36()" 5)" <a<0" )+" <a<8F" H)"
.)(+6)(" 3" .)" 5Y3LL6+6%/" G&4(" .)7" .&-36+)7" <k" OG5)$e7%(6+"
I&-&5&;&47".&-36+Q".)7"e6+37)7"De%")%"<@n!")%",3"5)7"()$(4%)("B"53"
-)-'(3+)F"De%",3"="P%()"GI&7GI&(=5/)")%"3$%6,/)F"i+)"L&67"3$%6,/)?"
)55)",3"G&4,&6("GI&7GI&(=5)("4+";(3+."+&-'()".)"$6'5)7"$)554536()7"
6-G56J4/)7" .3+7" .6LL/()+%7" G(&$)7747" %)57" J4)" 5Y3+;6&;)+A7)?" 53"
G(&;()776&+" .4" $=$5)" $)554536()?" 53" 74(,6)" $)554536()?" 53"7=+%IA7)" .)"
;5=$&;A+)")%"53"$(&6773+$)"$)554536()"!"#"53"e6+37)"-l#:"34"7)6+".4"
$&-G5)N)"-l#:H!F"
@)7"6+I6'6%)4(7".)"-l#:")%".YDe%"&+%"./KB"/%/"./,)5&GG/7")%"%)7%/7"
)+" )77367" $56+6J4)7" .)" GI37)" a?" aa" )%" aaaF" ^N$)G%/" .3+7" 5)" $37" .4"
$3($6+&-)" (/+35?" 65" 3GG3(3o%" J4)" $)7" 6+I6'6%)4(7" &+%" .)7" )LL)%7"
./$),3+%7F"H)7"(/745%3%7"&+%"/%/"(/$)--)+%"$&-G(67"4+)"L&67"J4)"53"
,&6)"De%"36%"/%/"-6)4N"/%4.6/)F"@Y4+)"G3(%?"5)7".)4N"e6+37)7"De%")%"
-l#:"G)4,)+%"P%()"$&4($6($46%/)7"G3("5)"L36%"J4)"<@n!")7%"$3G3'5)"
.Y3$%6,)(".6()$%)-)+%"53"C9e6+37)F"@Y34%()"G3(%?"65")N67%)"4+)",&6)".)"
(/%(&$&+%(Z5)" .)" 5Y3$%6,3%6&+" .)" <a8n" G3(" -l#:F" D6+76?" 5&(7J4)"
-l#:")7%"6+I6'/)?"<a8n"+)"G)4%"G547"5YP%()F"D5&(7?"<a8n",3"P%()"G547"
3$%6,/)")%"B"%)(-)?"4+")LL)%"()'&+.".)"5Y3$%6,3%6&+".)"53",&6)")%".&+$"
.YDe%" )%" .)" -l#:" 7)" G(&.46%F" a5" 3GG3(3o%" J4)" 76" 5Y&+" ,)4%" 6+I6')("
)LL6$3$)-)+%"53",&6)?"53"e6+37)"J4Y65"L34%"$6'5)(")7%"53"G()-6A()".)"53"
,&6)" <a8n" -367" -l#:" G)4%*P%()" 3$%6,/)" 6+./G)+.3--)+%" .)" <a8n"
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"
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3GG3(%6)++)+%" B" 53" -P-)" L3-655)" .)" e6+37)7" )%" J4)" .)" %(A7" '&+7"
6+I6'6%)4(7".&4'5)7"G)4,)+%"P%()"./,)5&GG/7F""
"
>)" G(&K)%" " H:anjD<De%?" L6+3+$/" .)" 011m" B" 01!!" G3(" 53" :/;6&+"
H)+%()?" /%36%" $&&(.&++/" G3(" %(&67"/J46G)7"&(5/3+367)7F" @)4N" .)"
'6&5&;6)" OHhj?" H]:C" i<:" \81!Q" .6(6;/)7" ()7G)$%6,)-)+%" G3(" ["
C$I&)+%;)+")%"k"h/+/.)%%6")%"4+)".)"$I6-6)?"C":&4%6)("OaH#D?"ij:"
H]:C"V8!!QF">)7"&'K)$%6L7".)"$)"G(&;(3--)"/%36)+%"T"
8mQ .)" $&+7%6%4)(" 4+" G53%)34" .)" %)7%7" '6&5&;6J4)7" G&4(" .&7)("
5Y3$%6,6%/" .)7" G(&%/6+)7" e6+37)7" .)7" ,&6)7" jD<" e6+37)7"
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)+M=-)7".)"$)7".)4N",&6)7".)"76;+35673%6&+F"
Tests*biologiques""
>)7" /%4.)7" .)" 53" ,&6)" :3LSj^nS^:n?" 5)7" %)7%7" -67" 34" G&6+%" )%" 5)7"
6+I6'6%)4(7" .)" :D[" 7=+%I/%67/7" &+%" L36%" 5Y&'K)%" .Y4+" 3(%6$5)" .3+7" 53"
5)%%()".Y6+L&(-3%6&+".)"5Y3N)"W"K3+,6)(*L/,(6)("01!1"X?"$)%%)"G3(%6)".4"
G(&K)%"+)"7)(3".&+$"G37"./,)5&GG/)".)"+&4,)34F"
>3" ,&6)" <a8nSDe%S-l#:" )7%" 4+)" ,&6)" .)" 76;+35673%6&+" 74(3$%6,/)"
.3+7" .)" +&-'()4N" $3+$)(7F" C3" 74(3$%6,3%6&+" )7%" 4+" L3$%)4(" .)"
(/767%3+$)"B"53"$I6-6&%I/(3G6)".3+7"$)(%36+7"$3+$)(7F""
<a8n" )7%" 3$%6,/)" G3(" .)7" (/$)G%)4(7" B" %=(&76+)" e6+37)" )%" .)7"
(/$)G%)4(7" $&4G5/7" 34N" G(&%/6+)7" EF" i+)" L&67" 3$%6,/)?" <a8n" ,3"
GI&7GI&(=5)(" 4+" GI&7GI&56G6.)" -)-'(3+36()" 5)" <a<0" )+" <a<8F" H)"
.)(+6)(" 3" .)" 5Y3LL6+6%/" G&4(" .)7" .&-36+)7" <k" OG5)$e7%(6+"
I&-&5&;&47".&-36+Q".)7"e6+37)7"De%")%"<@n!")%",3"5)7"()$(4%)("B"53"
-)-'(3+)F"De%",3"="P%()"GI&7GI&(=5/)")%"3$%6,/)F"i+)"L&67"3$%6,/)?"
)55)",3"G&4,&6("GI&7GI&(=5)("4+";(3+."+&-'()".)"$6'5)7"$)554536()7"
6-G56J4/)7" .3+7" .6LL/()+%7" G(&$)7747" %)57" J4)" 5Y3+;6&;)+A7)?" 53"
G(&;()776&+" .4" $=$5)" $)554536()?" 53" 74(,6)" $)554536()?" 53"7=+%IA7)" .)"
;5=$&;A+)")%"53"$(&6773+$)"$)554536()"!"#"53"e6+37)"-l#:"34"7)6+".4"
$&-G5)N)"-l#:H!F"
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,&6)"De%"36%"/%/"-6)4N"/%4.6/)F"@Y4+)"G3(%?"5)7".)4N"e6+37)7"De%")%"
-l#:"G)4,)+%"P%()"$&4($6($46%/)7"G3("5)"L36%"J4)"<@n!")7%"$3G3'5)"
.Y3$%6,)(".6()$%)-)+%"53"C9e6+37)F"@Y34%()"G3(%?"65")N67%)"4+)",&6)".)"
(/%(&$&+%(Z5)" .)" 5Y3$%6,3%6&+" .)" <a8n" G3(" -l#:F" D6+76?" 5&(7J4)"
-l#:")7%"6+I6'/)?"<a8n"+)"G)4%"G547"5YP%()F"D5&(7?"<a8n",3"P%()"G547"
3$%6,/)")%"B"%)(-)?"4+")LL)%"()'&+.".)"5Y3$%6,3%6&+".)"53",&6)")%".&+$"
.YDe%" )%" .)" -l#:" 7)" G(&.46%F" a5" 3GG3(3o%" J4)" 76" 5Y&+" ,)4%" 6+I6')("
)LL6$3$)-)+%"53",&6)?"53"e6+37)"J4Y65"L34%"$6'5)(")7%"53"G()-6A()".)"53"
,&6)" <a8n" -367" -l#:" G)4%*P%()" 3$%6,/)" 6+./G)+.3--)+%" .)" <a8n"
,63"+&%3--)+%"53",&6)":3LSj^nS^:nF""
"
H)%%)" 7%(3%/;6)" )7%" .Y34%3+%" G547" (/3567%)" J4)" <a8n" )%" -l#:"
3GG3(%6)++)+%" B" 53" -P-)" L3-655)" .)" e6+37)7" )%" J4)" .)" %(A7" '&+7"
6+I6'6%)4(7".&4'5)7"G)4,)+%"P%()"./,)5&GG/7F""
"
"
"
"
!
>)" G(&K)%" " H:anjD<De%?" L6+3+$/" .)" 011m" B" 01!!" G3(" 53" :/;6&+"
H)+%()?" /%36%" $&&(.&++/" G3(" %(&67"/J46G)7"&(5/3+367)7F" @)4N" .)"
'6&5&;6)" OHhj?" H]:C" i<:" \81!Q" .6(6;/)7" ()7G)$%6,)-)+%" G3(" ["
C$I&)+%;)+")%"k"h/+/.)%%6")%"4+)".)"$I6-6)?"C":&4%6)("OaH#D?"ij:"
H]:C"V8!!QF">)7"&'K)$%6L7".)"$)"G(&;(3--)"/%36)+%"T"
\!Q .)" $&+7%6%4)(" 4+" G53%)34" .)" %)7%7" '6&5&;6J4)7" G&4(" .&7)("
5Y3$%6,6%/" .)7" G(&%/6+)7" e6+37)7" .)7" ,&6)7" jD<" e6+37)7"
:3LSj^nS^:n"G467"<a8nSDnlS-l#:?" $)7",&6)7"+Y/%3+%"G547"
(/;45/)7".3+7".)"+&-'()4N"$3+$)(7?"
\0Q .)" ./,)5&GG)(" .)7" -&5/$45)7" $3G3'5)7" .Y6+I6')(" 5)7"
)+M=-)7".)"$)7".)4N",&6)7".)"76;+35673%6&+F"
Tests*biologiques""
>)7" /%4.)7" .)" 53" ,&6)" :3LSj^nS^:n?" 5)7" %)7%7" -67" 34" G&6+%" )%" 5)7"
6+I6'6%)4(7" .)" :D[" 7=+%I/%67/7" &+%" L36%" 5Y&'K)%" .Y4+" 3(%6$5)" .3+7" 53"
5)%%()".Y6+L&(-3%6&+".)"5Y3N)"W"K3+,6)(*L/,(6)("01!1"X?"$)%%)"G3(%6)".4"
G(&K)%"+)"7)(3".&+$"G37"./,)5&GG/)".)"+&4,)34F"
>3" ,&6)" <a8nSDe%S-l#:" )7%" 4+)" ,&6)" .)" 76;+35673%6&+" 74(3$%6,/)"
.3+7" .)" +&-'()4N" $3+$)(7F" C3" 74(3$%6,3%6&+" )7%" 4+" L3$%)4(" .)"
(/767%3+$)"B"53"$I6-6&%I/(3G6)".3+7"$)(%36+7"$3+$)(7F""
<a8n" )7%" 3$%6,/)" G3(" .)7" (/$)G%)4(7" B" %=(&76+)" e6+37)" )%" .)7"
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GI&7GI&(=5)(" 4+" GI&7GI&56G6.)" -)-'(3+36()" 5)" <a<0" )+" <a<8F" H)"
.)(+6)(" 3" .)" 5Y3LL6+6%/" G&4(" .)7" .&-36+)7" <k" OG5)$e7%(6+"
I&-&5&;&47".&-36+Q".)7"e6+37)7"De%")%"<@n!")%",3"5)7"()$(4%)("B"53"
-)-'(3+)F"De%",3"="P%()"GI&7GI&(=5/)")%"3$%6,/)F"i+)"L&67"3$%6,/)?"
)55)",3"G&4,&6("GI&7GI&(=5)("4+";(3+."+&-'()".)"$6'5)7"$)554536()7"
6-G56J4/)7" .3+7" .6LL/()+%7" G(&$)7747" %)57"J4)" 5Y3+;6&;)+A7)?" 53"
G(&;()776&+" .4" $=$5)" $)554536()?" 53" 74(,6)" $)554536()?" 53"7=+%IA7)" .)"
;5=$&;A+)")%"53"$(&6773+$)"$)554536()"!"#"53"e6+37)"-l#:"34"7)6+".4"
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"
Actualités*
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"
"
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"
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""
D"5_6774".4"$&+;(A7?"5)".&$%&(3+%"7)(3"7&556$6%/"G&4(T"
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"
Dans*l’attente*des*prochains*dossiers…*
"
"
"
>)" G(&K)%" " H:anjD<De%?" L6+3+$/" .)" 011m" B" 01!!" G3(" 53" :/;6&+"
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'6&5&;6)" OHhj?" H]:C" i<:" \81!Q" .6(6;/)7" ()7G)$%6,)-)+%" G3(" ["
C$I&)+%;)+")%"k"h/+/.)%%6")%"4+)".)"$I6-6)?"C":&4%6)("OaH#D?"ij:"
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)+M=-)7".)"$)7".)4N",&6)7".)"76;+35673%6&+F"
Tests*biologiques""
>)7" /%4.)7" .)" 53" ,&6)" :3LSj^nS^:n?" 5)7" %)7%7" -67" 34" G&6+%" )%" 5)7"
6+I6'6%)4(7" .)" :D[" 7=+%I/%67/7" &+%" L36%" 5Y&'K)%" .Y4+" 3(%6$5)" .3+7" 53"
5)%%()".Y6+L&(-3%6&+".)"5Y3N)"W"K3+,6)(*L/,(6)("01!1"X?"$)%%)"G3(%6)".4"
G(&K)%"+)"7)(3".&+$"G37"./,)5&GG/)".)"+&4,)34F"
>3" ,&6)" <a8nSDe%S-l#:" )7%" 4+)" ,&6)" .)" 76;+35673%6&+" 74(3$%6,/)"
.3+7" .)" +&-'()4N" $3+$)(7F" C3" 74(3$%6,3%6&+" )7%" 4+" L3$%)4(" .)"
(/767%3+$)"B"53"$I6-6&%I/(3G6)".3+7"$)(%36+7"$3+$)(7F""
<a8n" )7%" 3$%6,/)" G3(" .)7" (/$)G%)4(7" B" %=(&76+)" e6+37)" )%" .)7"
(/$)G%)4(7" $&4G5/7" 34N" G(&%/6+)7" EF" i+)" L&67" 3$%6,/)?" <a8n" ,3"
GI&7GI&(=5)(" 4+" GI&7GI&56G6.)" -)-'(3+36()" 5)" <a<0" )+" <a<8F" H)"
.)(+6)(" 3" .)" 5Y3LL6+6%/" G&4(" .)7" .&-36+)7" <k" OG5)$e7%(6+"
I&-&5&;&47".&-36+Q".)7"e6+37)7"De%")%"<@n!")%",3"5)7"()$(4%)("B"53"
-)-'(3+)F"De%",3"="P%()"GI&7GI&(=5/)")%"3$%6,/)F"i+)"L&67"3$%6,/)?"
)55)",3"G&4,&6("GI&7GI&(=5)("4+";(3+."+&-'()".)"$6'5)7"$)554536()7"
6-G56J4/)7" .3+7" .6LL/()+%7" G(&$)7747" %)57" J4)" 5Y3+;6&;)+A7)?" 53"
G(&;()776&+" .4" $=$5)" $)554536()?" 53" 74(,6)" $)554536()?" 53"7=+%IA7)" .)"
;5=$&;A+)")%"53"$(&6773+$)"$)554536()"!"#"53"e6+37)"-l#:"34"7)6+".4"
$&-G5)N)"-l#:H!F"
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)+" )77367" $56+6J4)7" .)" GI37)"a?" aa" )%" aaaF" ^N$)G%/" .3+7" 5)" $37" .4"
$3($6+&-)" (/+35?" 65" 3GG3(3o%" J4)" $)7" 6+I6'6%)4(7" &+%" .)7" )LL)%7"
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-l#:"G)4,)+%"P%()"$&4($6($46%/)7"G3("5)"L36%"J4)"<@n!")7%"$3G3'5)"
.Y3$%6,)(".6()$%)-)+%"53"C9e6+37)F"@Y34%()"G3(%?"65")N67%)"4+)",&6)".)"
(/%(&$&+%(Z5)" .)" 5Y3$%6,3%6&+" .)" <a8n" G3(" -l#:F" D6+76?" 5&(7J4)"
-l#:")7%"6+I6'/)?"<a8n"+)"G)4%"G547"5YP%()F"D5&(7?"<a8n",3"P%()"G547"
3$%6,/)")%"B"%)(-)?"4+")LL)%"()'&+.".)"5Y3$%6,3%6&+".)"53",&6)")%".&+$"
.YDe%" )%" .)" -l#:" 7)" G(&.46%F" a5" 3GG3(3o%" J4)" 76" 5Y&+" ,)4%" 6+I6')("
)LL6$3$)-)+%"53",&6)?"53"e6+37)"J4Y65"L34%"$6'5)(")7%"53"G()-6A()".)"53"
,&6)" <a8n" -367" -l#:" G)4%*P%()" 3$%6,/)" 6+./G)+.3--)+%".)" <a8n"
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"
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6+I6'6%)4(7".&4'5)7"G)4,)+%"P%()"./,)5&GG/7F""
"
>)" G(&K)%" " H:anjD<De%?" L6+3+$/" .)" 011m" B" 01!!" G3(" 53" :/;6&+"
H)+%()?" /%36%" $&&(.&++/" G3(" %(&67"/J46G)7"&(5/3+367)7F" @)4N" .)"
'6&5&;6)" OHhj?" H]:C" i<:" \81!Q" .6(6;/)7" ()7G)$%6,)-)+%" G3(" ["
C$I&)+%;)+")%"k"h/+/.)%%6")%"4+)".)"$I6-6)?"C":&4%6)("OaH#D?"ij:"
H]:C"V8!!QF">)7"&'K)$%6L7".)"$)"G(&;(3--)"/%36)+%"T"
\2Q .)" $&+7%6%4)(" 4+" G53%)34" .)" %)7%7" '6&5&;6J4)7" G&4(" .&7)("
5Y3$%6,6%/" .)7" G(&%/6+)7" e6+37)7" .)7" ,&6)7" jD<" e6+37)7"
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)+M=-)7".)"$)7".)4N",&6)7".)"76;+35673%6&+F"
Tests*biologiques""
>)7" /%4.)7" .)" 53" ,&6)" :3LSj^nS^:n?" 5)7" %)7%7" -67" 34" G&6+%" )%" 5)7"
6+I6'6%)4(7" .)" :D[" 7=+%I/%67/7" &+%" L36%" 5Y&'K)%" .Y4+" 3(%6$5)" .3+7" 53"
5)%%()".Y6+L&(-3%6&+".)"5Y3N)"W"K3+,6)(*L/,(6)("01!1"X?"$)%%)"G3(%6)".4"
G(&K)%"+)"7)(3".&+$"G37"./,)5&GG/)".)"+&4,)34F"
>3" ,&6)" <a8nSDe%S-l#:" )7%" 4+)" ,&6)" .)" 76;+35673%6&+" 74(3$%6,/)"
.3+7" .)" +&-'()4N" $3+$)(7F" C3" 74(3$%6,3%6&+" )7%" 4+" L3$%)4(" .)"
(/767%3+$)"B"53"$I6-6&%I/(3G6)".3+7"$)(%36+7"$3+$)(7F""
<a8n" )7%" 3$%6,/)" G3(" .)7" (/$)G%)4(7" B" %=(&76+)" e6+37)" )%" .)7"
(/$)G%)4(7" $&4G5/7" 34N" G(&%/6+)7" EF" i+)" L&67" 3$%6,/)?" <a8n" ,3"
GI&7GI&(=5)(" 4+" GI&7GI&56G6.)" -)-'(3+36()" 5)" <a<0" )+" <a<8F" H)"
.)(+6)(" 3" .)" 5Y3LL6+6%/" G&4(" .)7" .&-36+)7" <k" OG5)$e7%(6+"
I&-&5&;&47".&-36+Q".)7"e6+37)7"De%")%"<@n!")%",3"5)7"()$(4%)("B"53"
-)-'(3+)F"De%",3"="P%()"GI&7GI&(=5/)")%"3$%6,/)F"i+)"L&67"3$%6,/)?"
)55)",3"G&4,&6("GI&7GI&(=5)("4+";(3+."+&-'()".)"$6'5)7"$)554536()7"
6-G56J4/)7" .3+7" .6LL/()+%7" G(&$)7747" %)57" J4)" 5Y3+;6&;)+A7)?" 53"
G(&;()776&+" .4" $=$5)" $)554536()?" 53" 74(,6)" $)554536()?" 53" 7=+%IA7)" .)"
;5=$&;A+)")%"53"$(&6773+$)"$)554536()"!"#"53"e6+37)"-l#:"34"7)6+".4"
$&-G5)N)"-l#:H!F"
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-l#:"G)4,)+%"P%()"$&4($6($46%/)7"G3("5)"L36%"J4)"<@n!")7%"$3G3'5)"
.Y3$%6,)(".6()$%)-)+%"53"C9e6+37)F"@Y34%()"G3(%?"65")N67%)"4+)",&6)".)"
(/%(&$&+%(Z5)" .)" 5Y3$%6,3%6&+" .)" <a8n" G3(" -l#:F" D6+76?" 5&(7J4)"
-l#:")7%"6+I6'/)?"<a8n"+)"G)4%"G547"5YP%()F"D5&(7?"<a8n",3"P%()"G547"
3$%6,/)")%"B"%)(-)?"4+")LL)%"()'&+.".)"5Y3$%6,3%6&+".)"53",&6)")%".&+$"
.YDe%" )%" .)" -l#:" 7)" G(&.46%F" a5" 3GG3(3o%" J4)" 76" 5Y&+" ,)4%" 6+I6')("
)LL6$3$)-)+%"53",&6)?"53"e6+37)"J4Y65"L34%"$6'5)(")7%"53"G()-6A()".)"53"
,&6)" <a8n" -367" -l#:" G)4%*P%()" 3$%6,/)" 6+./G)+.3--)+%" .)" <a8n"
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"
H)%%)" 7%(3%/;6)" )7%" .Y34%3+%" G547" (/3567%)" J4)" <a8n" )%" -l#:"
3GG3(%6)++)+%" B" 53" -P-)" L3-655)" .)" e6+37)7" )%" J4)" .)" %(A7" '&+7"
6+I6'6%)4(7".&4'5)7"G)4,)+%"P%()"./,)5&GG/7F""
"
>)" G(&K)%" " H:anjD<De%?" L6+3+$/" .)" 011m" B" 01!!" G3(" 53" :/;6&+"
H)+%()?" /%36%" $&&(.&++/" G3(" %(&67"/J46G)7"&(5/3+367)7F" @)4N" .)"
'6&5&;6)" OHhj?" H]:C" i<:" \81!Q" .6(6;/)7" ()7G)$%6,)-)+%" G3(" ["
C$I&)+%;)+")%"k"h/+/.)%%6")%"4+)".)"$I6-6)?"C":&4%6)("OaH#D?"ij:"
H]:C"V8!!QF">)7"&'K)$%6L7".)"$)"G(&;(3--)"/%36)+%"T"
\VQ .)" $&+7%6%4)(" 4+" G53%)34" .)" %)7%7" '6&5&;6J4)7" G&4(" .&7)("
5Y3$%6,6%/" .)7" G(&%/6+)7" e6+37)7" .)7" ,&6)7" jD<" e6+37)7"
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(/;45/)7".3+7".)"+&-'()4N"$3+$)(7?"
\qQ .)" ./,)5&GG)(" .)7" -&5/$45)7" $3G3'5)7" .Y6+I6')(" 5)7"
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Tests*biologiques""
>)7" /%4.)7" .)" 53" ,&6)" :3LSj^nS^:n?" 5)7" %)7%7" -67" 34" G&6+%" )%" 5)7"
6+I6'6%)4(7" .)" :D[" 7=+%I/%67/7" &+%" L36%" 5Y&'K)%" .Y4+" 3(%6$5)" .3+7" 53"
5)%%()".Y6+L&(-3%6&+".)"5Y3N)"W"K3+,6)(*L/,(6)("01!1"X?"$)%%)"G3(%6)".4"
G(&K)%"+)"7)(3".&+$"G37"./,)5&GG/)".)"+&4,)34F"
>3" ,&6)" <a8nSDe%S-l#:" )7%" 4+)" ,&6)" .)" 76;+35673%6&+" 74(3$%6,/)"
.3+7" .)" +&-'()4N" $3+$)(7F" C3" 74(3$%6,3%6&+" )7%" 4+" L3$%)4(" .)"
(/767%3+$)"B"53"$I6-6&%I/(3G6)".3+7"$)(%36+7"$3+$)(7F""
<a8n" )7%" 3$%6,/)" G3(" .)7" (/$)G%)4(7" B"%=(&76+)" e6+37)" )%" .)7"
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GI&7GI&(=5)(" 4+" GI&7GI&56G6.)" -)-'(3+36()" 5)" <a<0" )+" <a<8F" H)"
.)(+6)(" 3" .)" 5Y3LL6+6%/" G&4(" .)7" .&-36+)7" <k" OG5)$e7%(6+"
I&-&5&;&47".&-36+Q".)7"e6+37)7"De%")%"<@n!")%",3"5)7"()$(4%)("B"53"
-)-'(3+)F"De%",3"="P%()"GI&7GI&(=5/)")%"3$%6,/)F"i+)"L&67"3$%6,/)?"
)55)",3"G&4,&6("GI&7GI&(=5)("4+";(3+."+&-'()".)"$6'5)7"$)554536()7"
6-G56J4/)7" .3+7" .6LL/()+%7" G(&$)7747" %)57" J4)" 5Y3+;6&;)+A7)?" 53"
G(&;()776&+" .4" $=$5)" $)554536()?" 53" 74(,6)"$)554536()?" 53" 7=+%IA7)".)"
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