CCO Managing Recurrent and Hypervirulent CDI

Confronting Challenges in the Management of
C difficile: Recurrent Infection and
Hypervirulent Strains

Faculty and Disclosures
Ciarán P. Kelly, MD
Professor of Medicine
Department of Medicine
Harvard Medical School
Attending Physician
Division of Gastroenterology
Department of Medicine
Beth Israel Deaconess Medical Center
Boston, Massachusetts
Ciarán P. Kelly, MD, has disclosed that he has received consulting fees from
Artugen, Merck, and Vedanta; fees for non-CME/CE services from Biocodex;
and funds for research support from Institut Merieux.

Program Overview
Burden of Disease
Diagnosis in 2018
Initial Management
Management of Recurrent Disease
Prevention of Recurrence

Burden of Disease

Symptomless carriage Diarrhea and colitis
Antibiotic therapy
Disturbed colonic microbiota
C difficile exposure and colonization
Toxin A and toxin B
CDI: An Opportunistic Infection
Kelly. NEJM. 2008;359:1932. Slide credit: clinicaloptions.com