Judith Favier - MeetOchondrie

JUDITH FAVIER!
INSERM U970!
PARIS-CENTRE DE RECHERCHE CARDIOVASCULAIRE!
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judith.fa[email protected]!
Rôles des gènes SDH dans la "
prédisposition au cancer!

L’effet Warburg!
Otto Warburg, 1931
Nobel Prize in
Physiology or Medicine
“Cancer cells downregulate their aerobic respiratory activity
and preferentially use glycolytic pathways to generate energy,
despite aerobic conditions.”!
Warburg, O. Über den Stoffwechsel der Tumore. Berlin: Springer. !
Translated: The metabolism of tumors. Lindon: Arnold Constable. !

M. G. Vander Heiden et al., Science 324, 1029 -1033 (2009)
Metabolic pathways active in proliferating cells are directly controlled by signaling pathways
involving known oncogenes and tumor suppressor genes!

SDHB!
SDHC!
SDHD!
SDHA!
La succinate déshydrogénase!