Abstract book

Acknowledgements
Bio-Rad
Bioveta
Merial
Sanofi-Pasteur
Virbac
Joint OIE/WHO/EU International Conference: “Towards the Elimination of Rabies in Eurasia”
ii Paris (France), 27-30 May 2007

Contents
■ Introduction ---------------------------------------------------------------------------------- 1
■ Objectives of the Conference-------------------------------------------------------------- 2
■ Topics ----------------------------------------------------------------------------------------- 2
■ Organisation of the Conference ----------------------------------------------------------- 4
■ General Information------------------------------------------------------------------------- 4
■ Programme ----------------------------------------------------------------------------------- 5
■ Abstracts-------------------------------------------------------------------------------------- 11
KEYNOTE ADDRESS
Towards the elimination of rabies in Eurasia: overview and perspectives--------------------------- 12
J. Blancou
SESSION 1 – EPIDEMIOLOGICAL INFORMATION, RABIES IN EURASIA: REGIONAL REPORTS
Map: Areas selected for regional reports ---------------------------------------------------------------- 13
Rabies situation in Western Europe ----------------------------------------------------------------------- 14
A.I. Wandeler
Rabies situation in Eastern Europe------------------------------------------------------------------------- 15
O. Matouch
Rabies situation in Central Asia ---------------------------------------------------------------------------- 16
K.N. Gruzdev
Rabies situation in the Middle East ------------------------------------------------------------------------ 17
A. Seimenis
Rabies situation in Far East Asia -------------------------------------------------------------------------- 18
Z.F. Fu
SESSION 2 – RABIES PATHOGENESIS
Cytokine expression in the CNS and periphery during infection with rabies ------------------------ 19
N. Johnson, K.L. Mansfield, D. Hicks, A. Nunez, D. Healy, S.M. Brookes, C. McKimmie,
J.K. Fazakerley & A.R. Fooks
Neuroimaging, virus and cytokine studies in rabies infected dogs ----------------------------------- 20
J. Laothamatas, S. Wacharapluesadee, B. Lumlertdacha,S. Ampawong, V. Tepsumethanon,
P. Phumesin,S.Asavaphatiboon, L.Worapruekjaru, Y.Avihingsanon, N.Israsena & T.Hemachudha
Role of Calcitonin Gene-Related Peptide (CGRP) in the pathogenesis of rabies-------------------- 21
E. Weihe, M. Bette, M.A.R. Preuss, M. Faber, M.K. Schäfer, M.J. Schnell & B. Dietzschold
Pathogenic and attenuated rabies viruses induce differential host protein expression in
the central nervous system: implication of neuronal dysfunction ------------------------------------- 22
Z.F. Fu
Joint OIE/WHO/EU International Conference: “Towards the Elimination of Rabies in Eurasia”
Paris (France), 27-30 May 2007 iii

Dominance of a non-pathogenic over a pathogenic G protein gene in defining the
pathogenicity of a rabies virus------------------------------------------------------------------------------ 23
B. Dietzschold
SESSION 3 – RABIES PREVENTION AND CONTROL STRATEGIES
Can rabies be eradicated? (Keynote speech)------------------------------------------------------------- 24
C.E. Rupprecht, J. Barrett, D. Briggs, F. Cliquet, A.R. Fooks, B. Lumlertdacha, F.-X. Meslin,
T. Müller, L.Nel, C. Schneider, N. Tordo & A. Wandeler
Rabies Control in Dogs
Molecular epidemiology of lyssaviruses in Eurasia ----------------------------------------------------- 25
L.M. McElhinney, D. Marston, S. Stankov, C. Tu, C. Black, N. Johnson, Y. Jiang, N. Tordo,
T. Müller & A.R. Fooks
Identification of novel canine rabies virus clades in the Middle East and North Africa ----------- 26
D. David, G.J. Hughes, B.A. Yakobson, I. Davidson, H. Un, O. Aylan, I.V. Kuzmin & C.E. Rupprecht
Rabies in South Asia - Epidemiological investigation--------------------------------------------------- 27
C.K.Singh & B.S. Sandhu
Stray dogs in Bangkok, Thailand: rabies virus infection and rabies antibody prevalence -------- 28
S. Kasempimolporn, B. Sichanasai, W. Saengseesom, S. Puempumpanich,
S. Chatraporn & V. Sitprija
Preference for commercially produced oral rabies baits by feral dogs ------------------------------ 29
D. Bergman, S. Bender, D. Slate, C. Rupprecht, K. Wenning, C. Heuser, S. Joe & T. Deliberto
Assessment of the efficacy of oral vaccination of shepherd dogs in supplement of oral rabies
vaccination of wild canids in Israel------------------------------------------------------------------------ 30
B. A. Yakobson, R. King, N. Sheihat & D. David
Longterm immunization of recombinant rabies-canine adenovirus type-2 in dogs after
intranasal or oral vaccination------------------------------------------------------------------------------- 31
S.F. Zhang, Y. Liu, A.R. Fooks, F. Zhang & R.L. Hu
New steps in the control of canine rabies in India ------------------------------------------------------ 32
H.K. Pradhan, J.P. Gurbuxani, F. Cliquet, B. Pattnaik, S.S. Patil, A. Regnault, H. Begouen,
A.L. Guiot, R. Sood, P. Mahl, R. Singh, E. Picard, M.F.A. Aubert, J. Barrat & F.-X. Meslin
Rabies in Mexico, 1990-2005------------------------------------------------------------------------------ 33
C.H. Álvarez Lucas
Risk of rabies introduction by non-commercial movement of pets------------------------------------ 34
P. Have, l. Alban, L.T. Berndtsson, F. Cliquet, P. Hostnik, S.C. Rodeia & M. Sanaa
Rabies Control in Wildlife
Epidemiology of rabies in South East Europe------------------------------------------------------------- 35
N. Johnson, C. Freuling, A. Vos, H. Un, R. Valtchovski, M. Turcitu, F. Dumitrescu, V. Vlad,
R. Velic, V. Sandrac, O. Aylan, T. Müller & A.R. Fooks
Rabies in Mongolian steppes ------------------------------------------------------------------------------- 36
A.D. Botvinkin, D. Otgonbaatar, S. Tsoodol & I.V. Kuzmin
Epidemiology and control of rabies in Iran --------------------------------------------------------------- 37
A.R. Janani & A. Fayaz
Rabies epidemiology in raccoon dogs and foxes -------------------------------------------------------- 38
A. Singer, K. Kauhala, K. Holmala & G.C. Smith
Downside risk of wildlife translocation-------------------------------------------------------------------- 39
R. Chipman, D. Slate, C. Rupprecht & M. Mendoza
Sylvatic rabies in Russia with special attention to perspectives of oral vaccination of
wild carnivores ------------------------------------------------------------------------------------------------ 40
A. D. Botvinkin, D.V. Bankovsky & G.A. Safonov
Joint OIE/WHO/EU International Conference: “Towards the Elimination of Rabies in Eurasia”
iv Paris (France), 27-30 May 2007

Finnish-Russian collaboration programme on rabies control in wildlife: the outcome of
five years and the future prospects ------------------------------------------------------------------------ 41
A.E. Metlin, S.S. Rybakov, K.N. Gruzdev, V.V. Mikhalishin, A. Huovilainen & E. Neuvonen
Rabies eradication programme in Estonia by means of oral vaccination of wildlife: first
results----------------------------------------------------------------------------------------------------------- 42
E. Niin, M. Laine & A. Pärtel
Rabies surveillance in Poland between 1992 - 2006--------------------------------------------------- 43
M. Smreczak, P. Trębas, A. Orlowska & J.F. Żmudziński
Efficacy of a square V-RG vaccine baits in red fox, domestic dog and raccoon dog--------------- 44
F. Cliquet, A.L. Guiot, C. Schumacher, J. Maki & J. Barrat
Scenario-analysis evaluating emergency strategies after rabies re-introduction ------------------ 45
H.-H. Thulke, D. Eisinger, T. Selhorst & T. Müller
The financial challenge to keep a large region free of rabies – the EU example------------------- 46
C. Freuling, T. Selhorst & T. Müller
What is the future of rabies control in Europe? ---------------------------------------------------------- 47
G.C. Smith, H.-H. Thulke, A.R. Fooks, M. Artois, D.W. Macdonald, D. Eisinger & T. Selhorst
The strength of 70% - revising a given threshold of rabies control ---------------------------------- 48
H.-H. Thulke & D. Eisinger
Rabies in Bats: an emerging zoonosis
A random grid based molecular epidemiological study on EBLV isolates from Germany---------- 49
C. Freuling, T. Selhorst, L. Geue, D. Marston, N. Johnson, A.R. Fooks, N. Tordo & T. Müller
Asymptomatic rhabdovirus infection in meridional serotine bats ( Ep esicus isabel nus ) t li
from Spain------------------------------------------------------------------------------------------------------ 50
J.E. Echevarría, S. Vázquez-Morón, C. Ibáñez, J.C. Aznar, E. Ruiz & J. Juste
Public health hazard of European bat lyssavirus, the Netherlands ----------------------------------- 51
W.H.M. Van Der Poel, K. Takumi, E.R.A.M. Verstraten, P.H.C. Lina,
J. Van Der Giessen & J.A. Kramps
Serological investigation of bats infected with rabies virus in China -------------------------------- 52
L. Wang, Y. Jiang, Z. Lu, K. Sun, H. Xuan, A. Fooks & C. Tu
Epidemiology and pathogenicity of African bat lyssaviruses------------------------------------------- 53
W. Markotter, C. Wilsenach & L.H. Nel et al.
Experimental infection of big brown bats ( Eptesicus fuscus ) with West Caucasian
bat virus -------------------------------------------------------------------------------------------------------- 54
I.V. Kuzmin, R. Franka & C.E. Rupprecht
Susceptibility of foxes ( Vulpes vulpes ) to European bat lyssaviruses types-1 and -2 ------------- 55
F. Cliquet, E. Picard, J. Barrat, S.M. Brookes, D.M. Healy & A.R. Fooks
Identification of British bat species using sequence comparison and its application to
European bat lyssavirus diagnosis and surveillance ---------------------------------------------------- 56
S.L. Harris, N. Johnson, S.M. Brookes, A.R. Fooks & G. Jones
Rabies Prevention in Humans
Human rabies includes early generalized vasospasm of cranial arteries that responds to
tetrahydrobiopterin, l-arginine or nitroprusside---------------------------------------------------------- 57
R.E. Willoughby, A. Roy-Burman, K.W. Martin, J.C. Christensen, D.F. Westenkirchner, C. Glaser,
C.E. Rupprecht & K. Hyland
Therapy of human rabies: lessons from experimental studies in a mouse model------------------- 58
A.C. Jackson, C.A. Scott, J. Owen, S.C. Weli & J.P. Rossiter
Rabies control and prevention in Georgia: current status and perspectives------------------------- 59
P. Imnadze, V. Surguladze, T. Tushishvili & l. Baidoshvili
Joint OIE/WHO/EU International Conference: “Towards the Elimination of Rabies in Eurasia”
Paris (France), 27-30 May 2007 v