Immunology Week Biopark, 16 - 20 decembre 2013 Introduction

Immunology Week
Biopark, 16 - 20 decembre 2013
Content
The immune system as an anti-cheating device
Class recognition by the innate immune response
Inflammation: the stereotyped innate immune
response
The somatic generation of a diverse adaptive
repertoire
Allelic/locus exclusion: central tolerance and
memory
Receptor specificity: somatic mutations
Receptor specificity: MHC restriction
Effectors of the adaptive immune response
Immune risk assessment and the choice of effector
mechanisms
Immunosuppression: central and peripheral
mechanisms
Speaker
Oberdan Leo (Institute for Immunological Medicine ,
Université Libre de Bruxelles)
Biopark - 16/12/2013 - 9:30-13:00
Introduction
Content
Basic course: An introduction to innate
immunity
• General concept of innate immune
recognition (PRR, effector trigger immunity)
• Concept of tolerance/endurance
• Interaction between stress, repair and
immune pathways
 An introduction to Drosophila systemic
response illustrating some of these concepts
Research seminar: The Drosophila gut:
innate immunity in epithelia
Speaker
Bruno Lemaître (The Global Health Institute,
Ecole Polytechnique Fédérale de Lausanne )
Biopark - 16/12/2013 - 14:00-17:30
Innate immunity
Content
Basic course: Intestinal Immune tolerance 
 The Mucosal Immune System
 The mucus and the epithelial barrier
 Intestinal flora
 IgAs
 Oral Tolerance
 Inflammatory bowel diasease and other
intestinal immune mediated disorders
Research seminar: Enteric nervous system as
modulator of intestinal immune homeostasis
Speaker
Gianluca Matteoli (Translational Research Center
for Gastrointestinal Disorders, KULeuven )
Biopark - 17/12/2013 - 9:30-13:00
Instestinal immunity
Content
Basic course: Dendritic cells and antigen
presentation
 Antigen presentation pathways
 Key properties of dendritic cells
 Dendritic cell subsets
 Mechanisms of cross-presentation
 Priming vs tolerance
Research seminar: Functional properties
of human dendritic cell subsets
Speaker
Elodie Segura (Immunity and Cancer,
Institut Curie, Paris) 
Biopark - 17/12/2013 - 14:00-17:30
Antigen presentation
Speaker
Jo Van Ginderachter (VUB)
Speaker
Arnaud Marchant (ULB, IMI)
Biopark - 18/12/2013 - 9h30-13h00
Neonatal Immunity
Content
Basic course & research seminar: Natural
Killer cells, Innate Lymphoid cells and Innate
Immunity 
 Natural Killer (NK) cells are Innate Lymphoid
cells (ILC)
 NK cells can be cytotoxic and secrete an array
of cytokines and chemokines that participate to
the shaping of the immune responses
 NK cells participate to the early control of virus
infection in human and mouse
 NK cells adapt to their host environment
 Anti-cancer function of NK cells can be boosted
by innovative immunotherapies
Speaker
Prof. Eric Vivier (Centre d’Immunologie de
Marseille-Luminy )
Biopark - 18/12/2013 - 14:00-17:30
Natural Killer cells
Content
Basic course: The coming of age of tumor
immunology and immunotherapy of cancer
 Tumors as well as transformed cells are recognized
by the adaptive immune system
 Immunosurveillance: the Immune Editing of
Tumors model
 Immunomonitoring of tumor-specific T cell
immunity
 Cancer immunotherapies: adoptive cell transfer,
therapeutic vaccines, immunomodulatory
monoclonal antibodies
 Role of immune responses in conventional anti-
cancer therapies
Research seminar: Regulation of tumor antigen
specific CD8 T cell immunity
Speaker
Prof. Pedro Romero (Ludwig Center for Cancer
Research, University of Lausanne )
Biopark - 19/12/2013 - 9:30-13:00
Anti-tumoral immunity
Content
Basic course: Regulatory T cells: Biology and
their role in human diseases
 Regulatory T cells:
- Development
- Peripheral homeostasis
- Immunosupressive function
- Treg subsets
 Regulatory T cells in primary immunodeficiency
disorders
 Regulatory T cells in graft-versus-host disease
(GVHD)
Research seminar: Regulatory T cells peripheral
homeostasis
Speaker
Stephanie Humblet-Baron (Laboratory of Genetics
of Autoimmunity, KULeuven)
Biopark - 19/12/2013 - 14:00-17:30
Regulatory T cells
Content
Basic course: History of cell death
Research seminar: Molecular
mechanisms and in vivo role of necroptosis
Speaker
Prof. Peter Vandenabeele (VIB
Inflammation Research Center, Ghent
University)
Biopark - 2012/2013 - 9:30-13:00
Cell death
Content
Basic course: Basic mechanisms of
allergic inflammation
- Incidence of allergic diseases is rising
- Eosinophilic inflammation
- Role of mast cells and basophils
- Role of ILCII vs Th2 cells
- Role of IgE in allergy
Research seminar: Dendritic cell and
epithelial cell interactions at the origin of
asthma
Speaker
Prof. Bart Lambrecht (VIB Inflammation
Research Center, Ghent University)
Biopark - 20/12/2013 - 14:00-17:30
Allergy (asthma)
Macrophages