Immunology Week Biopark, 16 - 20 decembre 2013 Innate immunity Introduction Content The immune system as an anti-cheating device Class recognition by the innate immune response Inflammation: the stereotyped innate immune response The somatic generation of a diverse adaptive repertoire Allelic/locus exclusion: central tolerance and memory Receptor specificity: somatic mutations Receptor specificity: MHC restriction Effectors of the adaptive immune response Immune risk assessment and the choice of effector mechanisms Immunosuppression: central and peripheral mechanisms Content Basic course: An introduction to innate immunity Basic course: Intestinal Immune tolerance The Mucosal Immune System The mucus and the epithelial barrier Intestinal flora IgAs Oral Tolerance Inflammatory bowel diasease and other intestinal immune mediated disorders Research seminar: The Drosophila gut: innate immunity in epithelia Speaker Oberdan Leo (Institute for Immunological Medicine , Université Libre de Bruxelles) Speaker Bruno Lemaître (The Global Health Institute, Ecole Polytechnique Fédérale de Lausanne ) Biopark - 16/12/2013 - 9:30-13:00 Biopark - 16/12/2013 - 14:00-17:30 Natural Killer cells Content Basic course & research seminar: Natural Killer cells, Innate Lymphoid cells and Innate Immunity Natural Killer (NK) cells are Innate Lymphoid cells (ILC) NK cells can be cytotoxic and secrete an array of cytokines and chemokines that participate to the shaping of the immune responses NK cells participate to the early control of virus infection in human and mouse NK cells adapt to their host environment Anti-cancer function of NK cells can be boosted by innovative immunotherapies Speaker Prof. Eric Vivier (Centre d’Immunologie de Marseille-Luminy ) Biopark - 18/12/2013 - 14:00-17:30 Research seminar: Enteric nervous system as modulator of intestinal immune homeostasis Speaker Gianluca Matteoli (Translational Research Center for Gastrointestinal Disorders, KULeuven ) Biopark - 17/12/2013 - 9:30-13:00 Anti-tumoral immunity Content Basic course: The coming of age of tumor immunology and immunotherapy of cancer Macrophages Content Content • General concept of innate immune recognition (PRR, effector trigger immunity) • Concept of tolerance/endurance • Interaction between stress, repair and immune pathways An introduction to Drosophila systemic response illustrating some of these concepts Antigen presentation Instestinal immunity Basic course: Dendritic cells and antigen presentation Antigen presentation pathways Key properties of dendritic cells Dendritic cell subsets Mechanisms of cross-presentation Priming vs tolerance Research seminar: Functional properties of human dendritic cell subsets Speaker Elodie Segura (Immunity and Cancer, Institut Curie, Paris) Biopark - 17/12/2013 - 14:00-17:30 Regulatory T cells: - Development - Peripheral homeostasis - Immunosupressive function - Treg subsets Regulatory T cells in primary immunodeficiency disorders Regulatory T cells in graft-versus-host disease (GVHD) Research seminar: Regulation of tumor antigen specific CD8 T cell immunity Research seminar: Regulatory T cells peripheral homeostasis Speaker Prof. Pedro Romero (Ludwig Center for Cancer Research, University of Lausanne ) Speaker Stephanie Humblet-Baron (Laboratory of Genetics of Autoimmunity, KULeuven) Biopark - 19/12/2013 - 9:30-13:00 Biopark - 19/12/2013 - 14:00-17:30 Speaker Arnaud Marchant (ULB, IMI) Biopark - 18/12/2013 - 9h30-13h00 Allergy (asthma) Content Content Tumors as well as transformed cells are recognized by the adaptive immune system Immunosurveillance: the Immune Editing of Tumors model Immunomonitoring of tumor-specific T cell immunity Cancer immunotherapies: adoptive cell transfer, therapeutic vaccines, immunomodulatory monoclonal antibodies Role of immune responses in conventional anticancer therapies Neonatal Immunity Cell death Regulatory T cells Basic course: Regulatory T cells: Biology and their role in human diseases Speaker Jo Van Ginderachter (VUB) Content Basic course: History of cell death Research seminar: Molecular mechanisms and in vivo role of necroptosis Speaker Prof. Peter Vandenabeele (VIB Inflammation Research Center, Ghent University) Basic course: Basic mechanisms of allergic inflammation - Incidence of allergic diseases is rising Eosinophilic inflammation Role of mast cells and basophils Role of ILCII vs Th2 cells Role of IgE in allergy Research seminar: Dendritic cell and epithelial cell interactions at the origin of asthma Speaker Prof. Bart Lambrecht (VIB Inflammation Research Center, Ghent University) Biopark - 2012/2013 - 9:30-13:00 Biopark - 20/12/2013 - 14:00-17:30