Cognitive problems related Cognitive problems related to chemotherapy for non CNS disease

Cognitive problems related
Cognitive
problems
related
tochemotherapyfor
non
CNS disease
SanneSchagen
DivisionofPsychosocial
non
‐
CNS
disease
ResearchandEpidemiology

Literatureoncognitiveeffectsofcancerand
cancertherapy
PtswithCNSdiseasealmostuniversallyexperiencecognitive
df ti di th di d t
d
ys
f
unc
ti
on
d
ur
i
ng
th
e
di
seasecourse
d
ue
t
o:
•Diseaseburden
•Surgery,radiotherapy,chemotherapy
•Seizureandseizuretherapy

Cognitive function in patients with brain tumor
Cognitive
function
in
patients
with
brain
tumor
•preoperativecognitivefunctionpredictspostoperativecognitiveoutcome
•
postoperative cognitive function and changes in cognitive function after
•
postoperative
cognitive
function
and
changes
in
cognitive
function
after
concurrentchemoradiationisprognosticforsurvivaltime
ldil h d ff ii fi
•tumorre
l
ate
d
ep
il
epsy
h
asana
d
versee
ff
ectoncogn
i
t
i
ve
f
unct
i
on
•radiationandchemotherapyrelatedtoxicitiescanincludecognitivedecline

Increasingevidencethatchemotherapyfornon‐CNS
disease can also produce neurobiological changes
disease
can
also
produce
neurobiological
changes
thatareassociatedwithcognitiveproblems
Thiswillbethefocusofthecurrentpresentation

Chemotherapyandcognition
innon‐CNSadultcancerpatients
Self‐perceived cognitiveproblemsoftencenteronmemory
p
roblemsandthenotionthatanincreasedmentaleffortis
p
neededtoachieveresults:
“
Ipaper my house with post
‐
it notes reminding me where
I
paper
my
house
with
post
it
notes
reminding
me
where
thingsare,whattimemyappointmentsare,whenmy
friends’birthdaysare…. ”
“Automaticprocessesnowrequirefullattention”