Interview Dr Frisoni par S. Tochon 22.07.2014 V2

!"#$%!%&'(%"%
%
Interview du Pr Giovanni Frisoni, Professeur en neuroscience HUG, spécialiste du diagnostic précoce
Laboratoire de neuroimagerie du vieillissement (LANVIE) – [e-mail]
#$%&'()*%""+,-+",!.%/!.01,2!30.,4%
56$7%'8'9:';$%<%=:'>7*(%69%)*';9?@:*A%B(=A?A$%C%
)*'+,$'-% .$% &"/*,(% &,% '0% .,"#0*&1,+% 2(3+*+$%$&1% &'&+$21,45$% .$% &*'5"#$(% 5$&% 2"1,$01&% 6578$,9$(% .:'0$%
;'$5+*0;'$%9"0,<($=%0*'&%"/*0&%,01$((*#3%5$%!(%>,*/"00,%?(,&*0,@%A*,+,%&"%(32*0&$@%
%
B5% &:"#,1% .$%+*92($0.($% +$% ;',% &$% 2"&&$% ."0&% 5$% +$(/$"'% .:'0$% 2$(&*00$% "11$,01$% .$% 5"% 9"5".,$%
.:6578$,9$(@% C55$% "% 2$(.'% 5"% 939*,($% .$% &*0% "'1*4,*#("28,$% $1% .$/,$01% ",0&,% ."0&% 5:,0+"2"+,13% .$% &$%
2(*D$1$(%."0&%5$%E'1'(@%F$%2(3&$01%.$/,$01%,0&1"45$@%F"%2$(&*00$%($&&$01%'0$%"0#*,&&$%$-,&1$01,$55$@%
F$&%2$(&*00$&%;',%+*0&'51$01%2*'(%.$&%1(*'45$&%.$%939*,($%/$'5$01%&"/*,(%&,%$55$&%&*01%"11$,01$&%.$%5"%
9"5".,$%*'%0*0@%),%5"%(32*0&$%$&1%0*0=%,5%&:$0&',1%'0%"2",&$9$01@%),%5"%2$(&*00$%$&1%$0%$EE$1%"11$,01$%.$%5"%
9"5".,$%.:6578$,9$(=%5$%E",1%.$%9$11($%'0%0*9%&'(%&*0%9"5",&$=%.$%1(*'/$(%'0%+*'2"45$=%$&1%3#"5$9$01%
'0$%&*'(+$%.:"2",&$9$01%2*'(%5$%2"1,$01%."0&%5"%9$&'($%*G%5$%93.$+,0%&",1%5$%("&&'($(@%H*'1%$&1%."0&%5"%
E"I*0% .$% +*99'0,;'$(% 5"% 0*'/$55$@% B5% $&1% ,92*(1"01% ;'$% 5"% 2$(&*00$% &$01$% ;':$55$% 0:$&1% 2"&% &$'5$% $1%
;':$55$%&$("%&',/,$@%J"0&%+$%+*01$-1$=%5"%E"9,55$%D*'$%'0%(K5$%.31$(9,0"01%2*'(%("&&3(30$(%&*0%2(*+8$@%L$%
2"&%5$%1"("4'&1$(%;'"0.%&"%939*,($%.3E",55$=%E",($%2($'/$%.$%2"1,$0+$=%5:$01*'($(%$1%.*00$(%1*'D*'(&%5$%
9$&&"#$%,925,+,1$%;'$%M%D$%&',&%N%1$&%+K13&%O@%
6%0*1$(%;':'0%2(*45<9$%.$%939*,($%0:$&1%2"&%P%$0%&*,%P%&Q0*0Q9$%.$%9"5".,$%.:6578$,9$(@%R$%0:$&1%;'$%
5*(&;'$% 5$% 2(*45<9$% .$% 939*,($% &:"D*'1$%N% '0% 9"0;'$% .:"'1*0*9,$% ;'$% 5"% 2(*4"4,5,13% ;':,5% &:"#,&&$%
.:'0$%9"5".,$%.:6578$,9$(%$&1%"&&$7%8"'1$@%F$%.,"#0*&1,+%$&1%4$"'+*'2%25'&%.,EE,+,5$%N%2*&$(%5*(&;':,5%0:Q%"%
;':'0% 2(*45<9$% .$% 939*,($@% J,EE,+,5$% .$% &"/*,(% &:,5% &:"#,1% .:'0%.34'1% .$% 9"5".,$% .:6578$,9$(% *'% .$&%
+*0&3;'$0+$&%.$%5"%/,$,55$&&$@%
F$%.,"#0*&1,+%2(3+*+$%03+$&&,1$%.$&%9*Q$0&%1$+80*5*#,;'$&%,92*(1"01&%2*'(%.31$+1$(%5$&%9"(;'$'(&%.$%
5"%9"5".,$=%+:$&1SNS.,($%&"%&,#0"1'($%4,*5*#,;'$T%
U@%V3&*00"0+$%9"#031,;'$%
W@%!*0+1,*0%5*94",($%X"0"5Q&$%.'%5,;',.$%+328"5*S("+8,.,$0%
Y@%?J>S!CH%Z2$1%&+"0%1$2%E.#[@%
R:$&1% 5"% +*0D*0+1,*0% .$%+$&% 1(*,&% 9318*.$&% ;',% ($0.% 5$% .,"#0*&1,+% 2(3+,&% $1% E,"45$@%6+1'$55$9$01=% 5$&%
9"(;'$'(&% &*01% 3/"5'3&% "'-% \]>% $0% 1(*,&% 5,$'-% .,EE3($01&%T% R$01($% .$% 0$'(*S(".,*5*#,$=% +$01($% .$%
93.$+,0$%0'+53",($%$1%+$01($%.$%0$'(*%#3(,"1(,$@%

!"#$%"%&'(%"%
%
D2'2:2*7%)$@%&?E$9@%)$%@?67';$(%)$%7'%&'7')*$%C%
F$&%&=)*A'&$9:@=%&"0&%^1($%.$&%M%45*+_4'&1$(&%O%Z93.,+"9$01&%9,("+5$&[%2$'/$01%E",($%5"%.,EE3($0+$%$1%
",.$(%5$%9"5".$@%
F$%A?&B?(:$&$9:%)$@%B(?AF$@%T%F"%25'2"(1%.$&%+*92*(1$9$01&%.:"#,1"1,*0=%.:,((,1"4,5,13%$1%.:"#($&&,/,13%
.'%2"1,$01%0$%/,$01%2"&%.$%5"%9"5".,$%.:6578$,9$(=%9",&%.$&%2(*+8$&@%F$&%"11,1'.$&%.32(3+,"1,/$&%&*01%N%
2(*&+(,($@%C55$&%+(3$01%.$&% 1$0&,*0&%$1%'0%31"1%.$%+*0E'&,*0=%.3&1"4,5,&$01%5$%2"1,$01%#303("01%.$&%31"1&%
.:,0&*90,$% $1% .:"#,1"1,*0% ;',% "4*'1,&&$01% N% 5"% 2($&+(,21,*0% .$% 93.,+"9$01&% 2&Q+8*1(*2$&% ;',% 2$'/$01%
"4('1,(%5$%2"1,$01%&:,5&%0$%&*01%2"&%#3(3&%"/$+%'0%&*,0%$-1(^9$@%
F$%@:E7$%)$%8*$%T%?"/*(,&$(%5:"+1,/,13%28Q&,;'$%$1%*21$(%2*'(%'0%9,5,$'%&1,9'5"01%Z0,%1(*2%P%+"(%+$5"%(,&;'$%
.$%#303($(%.$%5"%+*0E'&,*0%P%0,%1(*2%2$'[@%%
G6BB7=&$9:@% '7*&$9:'*($@%T% C0% +*92539$01% N% '0% (3#,9$% "5,9$01",($% 3;',5,4(3=% *0% 2$'1% 2($&+(,($% "'%
2"1,$01% .$&% &'22539$01&% "5,9$01",($&@% R$'-S+,% "#,&&$01% +*99$% .$&% 93.,+"9$01&% 2*'(% +*94"11($% 5$&%
25";'$&%"9Q5*`.$&%$1%5$&%0*Q"'-%0$'(*E,4(,55",($&%;',%"22"(",&&$01%."0&%'0%+$(/$"'%"11$,01%.$%5"%9"5".,$%
.:6578$,9$(%$1%;',%&*01%5:$EE$1%.:'0$%&*(1$%.:,01*-,+"1,*0%2"(%9"0;'$%.:35,9,0"1,*0%.$&%2(*13,0$&@%
H(?;6$@%$IB=(*&$9:'7$@%T%5$&%2"1,$01&%*01%5"%2*&&,4,5,13%.$%1$&1$(%.$%0*'/$"'-%1(",1$9$01&@%
J(=$(%7$@%*9K('@:(6A:6($@%9=A$@@'*($@%<%7'%B(*@$%$9%AF'(;$%)$@%&'7')$@%)LM7NF$*&$(%
A'%5:"925$'(%.'%2(*45<9$%$1%&*0%3/*5'1,*0%N%/$0,(=%,5%&$(",1%D'.,+,$'-%.$%.,&2*&$(%N%>$0</$%P%1*'1%+*99$%
+$5"%&$%E",1%.3DN%"'%R\]A%.$%F"'&"00$%Z"/$+%5$%!(%V,+8"(.%?("+_*a,"_=%R8$E%.'%)$(/,+$%.$%0$'(*5*#,$[%P%
.:'0$%&1('+1'($%$1%.:'0%2K5$%.$%+*9231$0+$&%;',%2$(9$11$%.:"++'$,55,(%5$&%2"1,$01&%.:6578$,9$(%$1%.$%5$&%
E",($%2"&&$(%2"(%5$&%.,EE3($01$&%31"2$&%.'%.,"#0*&1,+%$0%'0%9^9$%$1%'0,;'$%5,$'@%
O9%BP7$%)L'::('A:*?9%Q6*%@L*9@A(*:%)'9@%7'%@:(':=;*$%>*?&=)*A'7$%)$%R$9S8$%%
)$5*0% 5$% !(*E$&&$'(% ?(,&*0,=% "E,0% .$% +*'/(,(% 5$&% 4$&*,0&% .$% 5"% 2*2'5"1,*0% &',&&$%ZUUYbccc% 2$(&*00$&%
"11$,01$&% .$% .39$0+$% $0% WcUY% $1% Yccbccc% N% 5:8*(,7*0% Wcdc[=% ,5% E"'.(",1% 0*0% 9*,0&% .$%+,0;%+5,0,;'$&%
&23+,"5,&3$&%ZF"'&"00$=%e'(,+8=%>$0</$=%f$(0$%$1%fg5$[@%F:$-,&1$0+$%.:'0%(3&$"'%.:,0&1,1'1,*0&%.3.,3$&%N%5"%
9"5".,$%.:6578$,9$(%"'(",1%5:"/"01"#$%.:35"(#,(%$1%.$%+*0&*5,.$(%5:$&2"+$%.$%($+8$(+8$%$1%.$%+*0&1,1'$(%
'0%2K5$%.:"11("+1,*0%.:$0/$(#'($%,01$(0"1,*0"5$%0*1"99$01%2*'(%>$0</$%;',%"%9,&3%.$%5*0#'$%."1$%$1%
"/$+%&'++<&%P%$0%2"(1$0"(,"1%"/$+%F"'&"00$%S%&'(%5$%4,*93.,+"5%$1%7'%($AF$(AF$%@6(%7$%A$(8$'6@%
%
%)*28,$%H*+8*0%