LES PUBLICATIONS SIGNALISATION, APOPTOSIS AND CANCER CNRS UMR 8161 Institut Pasteur de Lille University Lille Nord de France affiliated to IFR 142 Responsable David TULASNE 00 33 3 20 87 12 57 2010 Cazet A, Lefebvre J, Adriaenssens E, Julien S, Bobowski M, Grigoriadis A, Tutt A, Tulasne D, Le Bourhis X, Delannoy P. GD3 synthase expression enhances proliferation and tumor growth of MDA-MB-231 breast cancer cells through c-met activation. Mol Cancer Res, 2010, Oct 1. Choul-Li S, Leroy C, Leprivier G, Laitem C, Tulasne D, Aumercier M. Caspase cleavage of Ets-1 p51 generates fragments with transcriptional dominant-negative function. Biochem J, 2010, 426:229-241. 2009 Foveau B, Ancot F, Leroy C, Petrelli A, Reiss K, Vingtdeux V, Giordano S, Fafeur V, Tulasne D. Down-regulation of the met receptor tyrosine kinase by presenilindependent regulated intramembrane proteolysis. Mol Biol Cell, 2009, 20:2495-2507. Deheuninck J, Goormachtigh G, Foveau B, Ji Z, Leroy C, Ancot F, Villeret V, Tulasne D, Fafeur V. Phosphorylation of the MET receptor on juxtamenbrane tyrosine residue 1001 inhibits its caspase-dependent cleavage. Cell Signal, 2009, 21:1455-1463. Ancot F, Foveau B, Lefebvre J, Leroy C, Tulasne D. Proteolytic cleavages give receptor tyrosine kinases the gift of ubiquity. Oncogene, 2009, 28:2185-2195. 2008 Deheuninck J, Foveau B, Goormachtigh G, Leroy C, Ji Z, Tulasne D, Fafeur V. Caspase cleavage of the MET receptor generates an HGF interfering fragment. Biochem Biophys Res Commun, 2008, 367:573-577. Firlej V, Ladam F, Brysbaert G, Dumont P, de Launoit Y, Benecke A, Chotteau-Lelièvre A. Reduced tumorigenesis in mouse mammary cancer cells following inhibition of either of the distinct Pea3 and Erm transcription programs. J Cell Sci, 2008, 121:3393-3402. Tulasne D, Foveau B. The shadow of death on the MET tyrosine kinase receptor. Cell Death Differ, 2008, 15:427-434.(review) 2007 Foveau B, Leroy C, Ancot F, Deheuninck J, Ji Z, Fafeur V, Tulasne D. Amplification of apoptosis through sequential caspase cleavage of the MET tyrosine kinase receptor. Cell Death Differ, 2007, 14:752-764. Ji Z, Degerny C, Vintonenko N, Deheuninck J, Foveau B, Leroy C, Coll J, Tulasne D, Baert JL, Fafeur C. Regulation of the Ets-1 transcription factor by sumoylation and ubiquitinylation. Oncogene, 2007, 26: 395-406. Yan Y, Tulasne D, Browaeys E, Cailliau K, Khayath N, Pierce RJ, Trolet J, Fafeur V, Ben Younes A, Dissous C. Molecular cloning and characterisation of SmSLK, a novel Ste20-like kinase in Schistosoma mansoni. Int J Parasitol, 2007, 14:1539-1550. PhD Bénedicte FOVEAU Directeur : D. Tulasne PhD "Biologie-Santé" Université de Lille Novembre 2007 HDR Anne CHOTTEAU HDR Université de Lille 1 Septembre 2009