Voir la présentation (médecine personnalisée)

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ITMO Cancer
From Precision to
Personalised Medicine
Brussels 24/09/2013
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Genomics in Oncology:
from biology to care
Generating information about cancer
development and metastasis
Identifying new genes susceptible to induce
« addiction », thus « targetable »
Helping to develop new therapies
Helping to accelerate new drug approval: new
early phase trials, shortening time to MA
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How are we currently using
genomics in patient management?
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Single Gene Alteration Multiple gene alterations
Already incorporated in
patient management
Impacts the following
decisions :
•Selection of agents:
−Positive effect
−Negative effect
•Prediction of toxicity
•Treatment changes in
case of resistance
Under investigation at
many institutions
Should it be incorporated in
routine care (when?) or
remain a research tool?
Is it practical?
What is the cost/benefit?

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Structures and Infrastructures:
Molecular genetic centers
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High quality molecular
testing, all patients,
anywhere in France
Partnerships between
University hospitals
and cancer centers
Regional organization
PPPs with Roche,
Amgen, Pfizer, GSK, AZ

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From genetic centers to biology
driven therapy
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F Nowak, JC Soria and F Calvo, Nat Rev Clin Oncol. 2012