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Biology & Chemistry of Radiations, Cell Signaling and Cancer
UMR3348 - Genotoxic stress and Cancer
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 Biology & Chemistry of Radiations, Cell Signaling and Cancer
 UMR3348 - Genotoxic stress and Cancer

UMR3348 – Genotoxic stress and Cancer
PARTAGER
 Presentation of the unitSeminarsInternational CoursesCommon ServicesUnit publications
Unit DirectorMounira Amor-Guéret Unit Deputy DirectorStéphan Vagner
The prevention of genomic instability and cancer depends on the
optimal functions of a complex network of pathways collectively
called the DNA damage response (DDR).
The research activities of our unit span several aspects of the DDR, intracellular signalling and genome
stability in response to genotoxic stress, either from endogenous sources (e.g. replication stress, mutations in
oncogenes and tumor suppressor genes) or from exogenous sources (e.g. oxidative stress, chemotherapeutic
agents, ionizing and UV radiation).
We are particularly interested by the functional relationships between what we call the “6Rs”: Replication,
Repair, Recombination, RNA biology, Redox regulation and responses to Radiations.
We specifically want to focus on:
 The network of cellular responses to exogenous and endogenous stresses,
 The influence of cell stress responses on cancer susceptibility and treatment efficacy,
 The hijacking of stress-induced responses for the development of new anti-cancer therapies.
The wide range of expertise of our teams in molecular and cellular biology, genetics and biochemistry allows
us to address these issues by using a great variety of technological approaches and several model
systems (yeast, mammalian cell lines, animal models).
Key publications
Year of publication 2017
Anissia Ait Saada, Ana Teixeira-Silva, Ismail Iraqui, Audrey Costes, Julien Hardy, Giulia Paoletti, Karine
Fréon, Sarah A E Lambert (2017 May 4)
Unprotected Replication Forks Are Converted into Mitotic Sister Chromatid Bridges.
Molecular cell : 398-410.e4 : DOI : 10.1016/j.molcel.2017.04.002

Simon Gemble, Géraldine Buhagiar-Labarchède, Rosine Onclercq-Delic, Christian Jaulin, Mounira Amor-
Guéret (2017 May 2)
Cytidine deaminase deficiency impairs sister chromatid disjunction by decreasing PARP-1
activity.
Cell cycle (Georgetown, Tex.) : 1-8 : DOI : 10.1080/15384101.2017.1317413
Hamza Mameri, Ivan Bieche, Dider Meseure, Elisabetta Marangoni, Géraldine Buhagiar-Labarchède, Andre
Nicolas, Sophie Vacher, Rosine Onclercq-Delic, Vinodh Rajapakse, Sudhir Varma, William C Reinhold, Yves
Pommier, Mounira Amor-Guéret (2017 Apr 15)
Cytidine deaminase deficiency reveals new therapeutic opportunities against cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research : DOI :
10.1158/1078-0432.CCR-16-0626
Hermela Shimelis, Romy L S Mesman, Catharina Von Nicolai, Asa Ehlen, Lucia Guidugli, Charlotte Martin,
Fabienne Mgr Calleja, Huong Meeks, Emily Hallberg, Jamie Hinton, Jenna Lilyquist, Chunling Hu, Cora M
Aalfs, Kristiina Aittomaki, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Matthias W Beckmann,
Javier J Benitez, Natalia Bogdanova, Stig E Bojesen, Manjeet K Bolla, Anne-Lise Borresen-Dale, Hiltrud
Brauch, Paul Brennan, Hermann Brenner, Annegien Broeks, Barbara Brouwers, Thomas Bruning, Barbara
Burwinkel, Jenny Chang-Claude, Georgia Chenevix-Trench, Ching-Yu Cheng, Ji-Yeob Choi, J Margriet
Collée, Angela Cox, Simon S Cross, Kamila Czene, Hatef Darabi, Joe Dennis, Thilo Dork, Isabel Dos Santos
Silva, Alison M Dunning, Peter A Fasching, Jonine D Figueroa, Henrik Flyger, Montserrat Garcia-Closas,
Graham G Giles, Gord Glendon, Pascal Guenel, Christopher A Haiman, Per Hall, Ute Hamann, Mikael
Hartman, Frans B L Hogervorst, Antoinette Hollestelle, John L Hopper, Hidemi Ito, Anna Jakubowska,
Daehee Kang, Veli-Matti Kosma, Vessela Kristensen, Kah-Nyin Lai, Diether Lambrechts, Loic Le Marchand,
Jingmei Li, Annika Lindblom, Artitaya Lophatananon, Jan Lubinski, Eva Machackova, Arto Mannermaa, Sara
Margolin, Frederik Marme, Keitaro Matsuo, Hui Miao, Kyriaki Michailidou, Roger L Milne, Kenneth Muir,
Susan L Neuhausen, Heli Nevanlinna, Janet E Olson, Curtis Olswold, Jan C Oosterwijk, Ana Osorio, Paolo
Peterlongo, Julian Peto, Paul D P Pharoah, Katri Pylkäs, Paolo Radice, Muhammad U Rashid, Valerie
Rhenius, Anja Rudolph, Suleeporn Sangrajrang, Elinor J Sawyer, Marjanka K Schmidt, Minouk J
Schoemaker, Caroline M Seynaeve, Mitul Shah, Chen-Yang Shen, Martha J Shrubsole, Xiao-Ou Shu, Susan L
Slager, Melissa C Southey, Daniel O Stram, Anthony J Swerdlow, Soo Hwang Teo, Ian Tomlinson, Diana
Torres, Therese Truong, Christi J van Asperen, Lizet E van der Kolk, Qin Wang, Robert Winqvist, Anna H
Wu, Jyh-Cherng Yu, Wei Zheng, Ying Zheng, Jennifer Leary, Logan C Walker, Lenka Foretova, Florentia
Fostira, Kathleen Claes, Liliana Varesco, Setareh Moghadasi, Douglas F Easton, Amanda B Spurdle, Peter
Devilee, Harry Vrieling, Alvaro N Monteiro, David E Goldgar, Aura Carreira, Maaike P G Vreeswijk, Fergus
J Couch (2017 Mar 10)
BRCA2 hypomorphic missense variants confer moderate risks of breast cancer.
Cancer research : DOI : 10.1158/0008-5472.CAN-16-2568
Rocchetti F, Tran Quang C, Maragno AL, Nguyen J, Lasgi C, Ghysdael J. (2017 Jan 1)
The calcineurin protein phosphatase is dispensable for BCR-ABL-induced B-ALL
maintenance, propagation and response to dasatinib.
Leukemia : DOI : 10.1038/leu.2016.269
Year of publication 2016
Michelle Newman, Rym Sfaxi, Abhijit Saha, David Monchaud, Marie-Paule Teulade-Fichou, Stéphan Vagner
(2016 Dec 7)
The G-Quadruplex-Specific RNA Helicase DHX36 Regulates p53 Pre-mRNA 3′-End
Processing Following UV-Induced DNA Damage.
Journal of molecular biology : S0022-2836(16)30528-9 : DOI : 10.1016/j.jmb.2016.11.033

 Presentation of the unit
 Seminars
 International Courses
 Common Services
 Unit publications
News
11/05/2017 Unprotected Replication Forks Are Converted into Mitotic Sister Chromatid Bridges
DNA Recombination, Replication and Genome Stability (CNRS/Institut Curie) group, leaded by
Sarah Lambert, published in Molecular Cell. Research reveals how stressed forks, unprotected
by the recombination machinery, trigger mitotic defect and genome...
25/04/2017 BRCA2 hypomorphic missense variants confer moderate risks of breast cancer.
Cancer Res. 2017 Mar 10. pii: canres.2568.2016. doi: 10.1158/0008-5472.CAN-16-2568. [Epub
ahead of print] BRCA2 hypomorphic missense variants confer moderate risks of breast cancer.
Shimelis H1, Mesman RL2, Von Nicolai C3, Ehlen A3,...
Aura Carreira Médaille de bronze du CNRS 2017 Aura Carreira mène l’équipe Recombinaison
Homologue et Cancer (CNRS/Université Paris-Sud/Institut Curie) dans les laboratoires d’Orsay
du centre de recherche de l’institut Curie. La jeune scientifique a reçu la prestigieuse médaille de
bronze...
16/09/2016 A novel DNA binding domain in BRCA2 with possible implications in breast cancer
risk BRCA2 tumour suppressor protein has a recognized role in the repair of DNA double strand
breaks by homologous recombination. The work of the Homologous Recombination and Cancer
team describes a novel DNA...
Teams
 Team Amor-Guéret
 Team Carreira
 Team Ghysdael
 Team Huang
 Team Janke
 Team Lambert
 Team Vagner
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