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"Conclusion.+Chez+les+patients+NASH+prenant+une+dose+de+120+mg+par+jour,+le+GFT505+a+induit+
une+amélioration+histologique+et+la+résolution+de+la+NASH+beaucoup+plus+souvent+que+le+
Placebo.+L'excellente+innocuité,+la+tolérabilité+et+l'amélioration+du+profil+de+risque+
cardiométabolique+fait+du+GFT505+d'un+médicament+candidat+idéal+pour+être+testé+en+phase+
3+»+
+
c&!$(+,!9%1$4/(/!4.(9!9(!7+*-2'!#9/-.4-(&,!(&!9%&92+'-%&!)(!24!$+O2-94,-%&!)('!/#'+2,4,'!)(!
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)(+W!$+O2-94,-%&'E!!!
+
«+Malgré+l'amélioration+des+caractéristiques+clés+de+la+stéatohépatite+non+alcoolique,+y+
compris+la+fibrose,+ces+améliorations+ne+suffisent+pas+à+réduire+le+nombre+de+patients+avec+un+
diagnostic+de+stéatohépatite+non+alcoolique.+Les+résultats+positifs+sont+tempérés+par+
l'observation+du+prurit+chez+23%+des+patients+et+une+augmentation+de+cholestérol+total+et+de+
cholestérol+LDL+et+une+diminution+modeste+du+cholestérol+HDL.+Des+études+à+long+terme+sont+
nécessaires+pour+confirmer+les+effets+bénéfiques+de+l'acide+obéticholique+chez+les+patients+
avec+stéatohépatite+non+alcoolique,+et+de+déterminer+la+pertinence+clinique+des+modifications+
de+lipides+circulants+induits+par+des+ligands+de+récepteurs+farnésoïde+X+»++
+
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