BioTech 3
2019-2020
Fundamental Immunology
Danielle PEREZ-BERCOFF
dan.bercof[email protected]
Module 1:
Innate and Adaptive
Immune Responses
Introduction
3 Modules:
•Innate immune response
Initiation of adaptive immune response
CD4 T cells
•Tand B ontogeny
Humoral response (B cells)(adaptive)
•Cytotoxic responses
- cellular response : CD8 T cells(adaptive)
- NK cells (innate)
Danielle Perez Bercoff
Danielle Perez Bercoff
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Module 1: Course outline
Danielle Perez-Bercoff
Biotech3:2019-2020
•Introduction to Immunology
•Innate Immunity
•The Complement System
•Innate response: Cellular effectors
- Cellular effectors
- Immune sensors
- Induction of co-stimulatory molecules
•HLA and antigen presentation
-Antigen presentation by HLA
- Antigen processing
•Activation of T lymphocytes
Module 1: Course outline
Danielle Perez-Bercoff
Biotech3:2019-2020
•Introduction to Immunology
•Innate Immunity
•The Complement System
•Innate response: Cellular effectors
- Cellular effectors
- Immune sensors
- Induction of co-stimulatory molecules
•HLA and antigen presentation
-Antigen presentation by HLA
- Antigen processing
•Activation of T lymphocytes
Introduction Immunologyand vaccinology history
Late of 18th century: Edward Jenner beginning of immunology
Vaccinia (mild disease of cowpox) seemed to confer protection
against smallpox (often fatal disease)
1796: inoculation with cowpox protectedthe recipientagainst smallpox
concept of vaccination
1979: WHO announces the eradication of smallpox
Edward Jenner
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