Ca cer is ased o a utaio of the DNA. Ca cerous cells reproduce the sel es a d i duce alfu cio i the orga here the proliferate. There is a lot of ca cers a d a a s to cure the like surger a d he otherap . But these techi ues are ot % eicie t a d e eed to i d alter ai es. Prostate ca cer is o e of the ost i porta t ca cers, t ice as pre ale t as lu g ca cer a d the seco d cause of death fro We use radiaio therap to cure prostate ca cer ut there are issues. IMRt ri gs pro le s of o -precise dose deli er a d the proto therap is er e pe si e. The ai issue ith sta dard che otherap is that e ca ot eicie tl co trol the gro th of the tu or ecause it is diicult to ai tai therapeuic pa loads i the tu or. The ca e created a d desig ed to atch perfectl ith the tu or a d therefore deli er opi ized treat e t. ca cer. Gold a opari les are a atraci e alter ai e for paie ts. Gree tea as disco ered i Chi a, ears ago. Gree tea has sho properies that preve t ple t of a er, cardio ascular diseases, dia etes a d Alzhei er disease. I fact, the rate of Chi ese e ith prostate ca cer is i es lo er tha i the rest of the orld. EGCg Epigallocatechi gallate is a ph toche ical co po e t of gree tea a d it as used i utriio al supple e ts ecause of it’s stro g a io ida t properies. EGCg has pro ed it’s eicie c to cure rai , prostate reast a d colo ca cers. So, e ha e to co i e radioaci e a oparicles, Au1 , ith the EGCg. EGCg is applied o Gold a oparicles ca suppl at the sa e i e i agi g a d therapeui a iliies, it is called « thera osic ». With these a oparicles, e radiate the tu or issue ith eta e issio , the e erg released is a out , MeV a d gold a oparicle’s half-life is , da s. The pe etraio ra ge of Au1 is up to 11 . These co i ed speciicaio s are suicie t e ough to destro tu or issues a d to prote t health issues arou d the tu or. the surfa e of the gold pari les. To destro the tu or, the a oparicles ha e to pass through the cell e ra e. The che ical co ple EGCG-AuNP has a speciicit to prostate tu or cells, a ed PC- cells. I fact, it is uch ore tha a that. O ce the co ple reaches the la i i receptor, La R, o the surface of the PC- cell, it ge erates a e doc tosis echa is , so the EGCG- Regardi g the s thesis of the co ple of EGCGAuNP, the researchers i sodiu tetrachloroaurate NaAuCl ith EGCg i deio ized ater. EGCg’s reducio properies are used to co ert gold salt i to gold a oparicles ithout usi g a to ic che ical. AuNP a e ter the ell a d destro it. It is a « Troja Horse » approach. For the o e t, there has ’t ee a ducted o hu a s. But o ce used, this radioaci e co po e t is eli iated the orga is . Studies sho that h ater % of the therapeui o ple is retai ed i the tu or ells. Where are the re ai i g the i jecio , %? I fact, a large part is eli i ated i the cells itself i the reiculoe dothelial s ste . A s all a ou t of these paricles are re o ed the kid e . As sho i the diagra elo , e ca i d so e a oparicles i the lood a d i o -target orga s. tests co - We ca co pare t o populaio s a i als: I the su jects of the co trol group, e i ject o l a sali e soluio or o l EGCg; The seco d group, is treated ith EGC-AuNP. We ca see that ater 1 da s the tu or olu e of the treated a i als is four i es s aller tha the tu or of the co trol group. Tu ors treated: Rete io of radioaci it i tu ors follo i g i tra-tu oral i jecio of 1 AUNP-EGCg i ice: Aurélie Gavelle & Mathieu Astra skas GBM To su arize, as this treat e t has a high adept ess it is a alter ai e to sta dard radiaio therapies. The dose of radiaio to treat the tu or is lo . There is a er s all part of health issues radiated duri g the treat e t. Hg is produced duri g the treat e t, ut at a o to ic dose, a d it is ell tolerated the orga is . Ple t of ca cers like colo , reast or rai ca cer ca e treated. So this tech ic has i teresi g perspeci es a d represe ts the future of ca cer treat e t.