ANTIOXIDANT TREATMENT OF PROSTATE CANCER

ANTIOXIDANT TREATMENT OF
PROSTATE CANCER
ROBERT BARD, MD
DIRECTOR, THE BIOFOUNDATION FOR
ANGIOGENESIS RESEARCH, NY
ASSOCIATE PROFESSOR RADIOLOGY
NEW YORK MEDICAL COLLEGE
VASCULAR DENSITY IMAGING
VASCULAR DENSITY APPROXIMATES TUMOR
AGGRESSION AND DECREASED VESSEL
NUMBERS CORRESPOND TO CLINICAL
IMPROVEMENT
3-D DOPPLER HISTOGRAM ANALYSIS OF THE
VESSEL NUMBER/CC PROVIDES A COMPUTER
GENERATED % OF TUMOR
VESSELS PER VOLUME ANALYSED
LOW <9% MEDIUM 10-20% HIGH> 21-30%
VERY HIGH > 30% USUALLY GLEASON 8-10
GLEASON 4+5=9
3-D PDS
DCE MRI
TUMOR VOLUME = 2 CC
NO ECE IDENTIFIED
VASCULAR DENSITY GLEAS0N 9
3D-PDS
VESSEL DENSITY = 35%
DCE- MRI
VERY HIGH>30
GOOD CONTROL
POSTEXTERNAL BEAM RADIATION
RASMUSSEN
6 MONTHS POST TREATMENT
GLEASON 8
VASCULAR INDEX DECREASES FROM 30 % TO 5 %
4 MONTH RESPONSE
TO ANTI-OXIDANT THERAPY
GLEASON 7
5/2005
REBIOPSY SHOWED GLEASON 6
PSA 33
9/2005
PSA 6
POOR CONTROL
8 MONTHS
WATCHFUL WAITING – NO ANTIOXIDANTS
GL 6 L BASE 9/2005
GL 8 R MID 5/2006
SEED + EXT BEAM FAILURE
arrow shows ECE which is not
imaged by S-MRI
2004 S-MRI
2004 EBT
2006 DCE-MRI
VASCULAR INDEX=7%
VASCULAR INDEX = 12%
PRE & POST THERMAL
ABLATION 2 WEEKS
QUESTIONS
1-Which modality is best to detect prostate cancer
A-ultrasound B-MRI C-CT
2-Which Gleason score has the worst prognosis
A-3+4=7 B-4+3=7 C- 3+2=5
3-Which vascular density is usual in Gleason 4+4
A-5% B-15% C-25%
ANSWERS
1-B-MRI is most specific
2-B-Gleason score 4 is high grade disease
3-C-Gleason sum 4+4=8 often has vascular
densities above 20%