Post San Antonio 2011 Dr André Robidoux

Post San Antonio 2011
Dr André Robidoux
Essai clinique avec bisphosphonate
• Gnant M et al: ABCSG-12
• Paterson AHG et al: NSABP protocol B-34
• Mobus V et al: GAIN study
• De Boer R et al: ZO-FAST
Thérapie néoadjuvante: Relation entre pCR et devenir chez les patientes
Her2- et Her2+
• Minckwitz G et al: GeparTrio Trial
• Loibl S et al: Metanalysis of the German Oncology Group
Oncotype Dx: DCIS recurrence score
• Solin LJ et al: DCIS recurrence score based on the results of
ECOG5194

Overall Structure of Bisphosphonates
R2 Chain
R1 Chain
PO3H2
C
Osteoclast PO3H2

This presentation is the intellectual property of the presenter. Contact [email protected] for permission to reprint and/or distribute.
!"#$%#&'()*&+$,#'-+$.*"/)0'12&3*4''
)5'674%8)4%8)+,*&4'7+'6)+&'
!"#$%&$%'&("#)*$%+&,-)$./&($%0)-&1).&23435426247&
9874'%0&4&+*,$)+'74'*8&'7+*&##&3*",#'%0)%&0*:')5'*8&'%0&4&+*&0;''<)+*,3*'7+=#&;>,/&4?/,:);&@"'5)0'%&0/7447)+'*)'0&%07+*',+@A)0'@74*07B"*&;&
C,+'-+*)+7)'60&,4*'<,+3&0'C:/%)47"/'D'<,+3&0'98&0,%:',+@'E&4&,038'<&+*&0',*'F9'G&,#*8'C37&+3&'<&+*&0'D'H&3&/B&0'I.JKL'MKJJ'

This presentation is the intellectual property of the presenter. Contact [email protected] for permission to reprint and/or distribute.
!"#$%&$%'&("#)*$%&,-)$./&($%0)-&1).&23435426247&
()*&+$,#'-+$.*"/)0'12&3*4')5'674%8)4%8)+,*&4''
N"*47@&'*8&'CO&#&*)+'
9874'%0&4&+*,$)+'74'*8&'7+*&##&3*",#'%0)%&0*:')5'*8&'%0&4&+*&0;''<)+*,3*'7+=#&;>,/&4?/,:);&@"'5)0'%&0/7447)+'*)'0&%07+*',+@A)0'@74*07B"*&;&
C,+'-+*)+7)'60&,4*'<,+3&0'C:/%)47"/'D'<,+3&0'98&0,%:',+@'E&4&,038'<&+*&0',*'F9'G&,#*8'C37&+3&'<&+*&0'D'H&3&/B&0'I.JKL'MKJJ'