STRATEGY EMERGING COMPANIES REGULATION FINANCE FINANCE COLUMN’S CREATIONS BY JENNIFER RHODES, STAFF WRITER Including milestones, Bristol-Myers Squibb Co.’s takeout of Flexus Biosciences Inc. late last month is enough to return the capital of The Column Group’s entire second fund. While it’s the third quick exit for TCG, the VC remains focused on creating and building platform companies it intends to hold for the long term. “We spend very little time looking at existing companies and close to all of our time just starting two to three companies a year around an exciting new area that we think will be a fruitful area to be doing drug discovery in 5-10 years’ time,” said founder and Managing Partner Peter Svennilson. The firm likes early stage drug discovery based on “unique scientific platforms with the potential to deliver multiple breakthrough therapeutics,” he said. “Each successful company should be able to return the whole fund, because we only have 8-10 bets,” per fund, he added. TCG closed its first fund with $260 million in 2008 and its second last October with $322 million. Svennilson said the returns from each of its exits, including the milestones, is enough to cover all the capital of the fund from which it came. Two exits came from the first fund, while the Flexus exit came from its new fund. TCG has put $15 million into Flexus since its launch less than two years ago and led the company’s tranched $25 million series B round last year. BMS is buying the cancer immunotherapy play for up to $1.3 billion, including $800 million up front, in a deal slated to close this month. On the upfront portion of the deal, TCG will see a 14x return, about $208 million; including the milestones, the firm would see over 21x, or about $325 million. The other two exits were prostate cancer company Aragon Pharmaceuticals Inc. and Aragon spinout Seragon Pharmaceuticals Inc. Johnson & Johnson bought Aragon in 2013 for $650 million up front and up to $350 million in milestones. TCG invested about $25 million in Aragon, which was founded in 2009, and owned about 23% at its acquisition. Roche’s Genentech Inc. unit acquired breast cancer play Seragon last year for $725 million up front and up to $1 billion in milestones. TCG invested about $8 million in Seragon in late 2013 and owned about 23% at the time of its acquisition. “We wouldn’t have thought we’d have an exit so soon in our fund,” said Svennilson. “When we raised our first and second fund, we told our investors that they needed to be very patient, that we were building companies over a horizon of 10 years and that they should not expect to get any early returns. 13 WEEK OF March 9, 2015 “It happened we got these bids, but that was luck, and we would have continued building those companies over the long term if we hadn’t been lucky to get early interest from pharma,” he said. TCG’s LPs include a large, undisclosed university endowment, sovereign wealth funds and several large family offices. Several of the LPs also coinvest in the firm’s portfolio companies “at a later stage when they can better evaluate where the company is and what the upside and risks are,” Svennilson said. “We have quite a focused group of investors who know us well and know our strategy and know our focus of building companies and value, but over the long term,” he said. “EACH SUCCESSFUL COMPANY SHOULD BE ABLE TO RETURN THE WHOLE FUND, BECAUSE WE ONLY HAVE EIGHT TO 10 BETS.” PETER SVENNILSON, THE COLUMN GROUP COMPANY CREATION TCG has four full-time partners and a team of six science partners who together come up with ideas for creating and building companies with the goal of launching two to three product engine plays per year. Svennilson said the firm targets an investment of $30-$40 million per company. The firm’s other three partners include Larry Lasky, a former Genetics Institute Inc. and Genentech scientist who was later at VCs Latterell Venture Partners and U.S. Venture Partners. David Goeddel was cofounder and CEO of cancer company Tularik Inc. and then senior scientific VP at Amgen Inc., which acquired Tularik. And Tim Kutzkey was a scientist at KAI Pharmaceuticals Inc., another Amgen acquisition. “We don’t look at deal flow or potential investment opportunities. We’d rather come up with our own ideas for companies and make sure they’re staffed with people we know well from the past,” said Svennilson. “We typically want to see a rich pipeline of programs for our companies, and not just sort of one lead drug.” It was Goeddel’s connections with Flexus’ management that led to TCG’s investment in the company. Goeddel had worked with Flexus CEO Terry Rosen and President and Head of R&D Juan Jaen, while at Tularik and later at Amgen. BIOCENTURY TOC STRATEGY “We knew them well, and we felt that it was as good as a company we had started ourselves,” said Svennilson, adding that it was a “very good example of how we want to build our companies.” Flexus is going after several targets in cancer immunotherapy and has multiple platform technologies. “We come up with our ideas in constant brainstorming sessions with our science partners,” he said. “We challenge each other to come up with the new breakthroughs in development that will yield the most exciting areas for research over the next 5-10 years. That’s how we started NGM, to go after the observation in bariatric surgery that the metabolic syndrome had been alleviated. It’s how we started Constellation.” Epigenetics play Constellation Pharmaceuticals Inc. is developing small molecule inhibitors of epigenetic targets, including a lead compound in Phase I testing targeting BET bromodomains. Genentech has an option to acquire Constellation under undisclosed terms. NGM Biopharmaceuticals Inc. is using its high throughput discovery platform to discover biologics for diabetes, obesity, muscle wasting and other cardiometabolic diseases. “When we went into metabolic disorders, not many other venture investors were investing in metabolic disorders because of the clinical development times and the cost of developing these drugs as a small biotech company,” said Svennilson. “But we found the research in that area was very exciting and novel and didn’t hesitate to build a company like NGM.” Last month, NGM and Merck & Co. Inc. announced a deal that gives Merck options to license multiple preclinical candidates from NGM, including cardiometabolic and cancer programs. Merck will pay NGM $94 million up front, purchase a 15% equity stake for $106 million, and provide up to $250 million in R&D funding over five years. It’s not an exit, but Svennilson said the deal will pay for most of the costs of developing NGM’s pipeline over the five years. “We intend to see this partnership through and see what the company looks like then,” he added. TCG has invested roughly $50 million in NGM, making it the largest stakeholder, with about 21% of the company; Merck is now the second largest investor. Other portfolio companies from the first fund include cancer vaccine play Immune Design Corp., which raised $60 million in an IPO last year, plus cancer companies Igenica Inc. and Peloton Therapeutics Inc. and ubiquitin proteasome play Nurix Inc. EMERGING COMPANIES REGULATION FINANCE Svennilson said the firm has so far closed down one company, which was developing a prodrug approach for cancer. TCG invested $4.5 million in Cyterix Pharmaceuticals Inc. before winding down operations. SECOND COLUMN The firm has made five investments from its second fund. Besides Flexus and NGM, the portfolio includes oncogene play Effector Therapeutics Inc., which Lasky helped launch while at USVP. TCG has disclosed few details on the two newcos launched from the second fund. One is cancer company ORIC Pharmaceuticals Inc., which Svennilson said is working on overcoming resistance mechanisms in cancer. The other is CNS play Neurona Therapeutics Inc., which is based on science from the University of California San Francisco on interneurons and neuronal stem cells. “We don’t need to see a drug lead program crystallized early on,” said Svennilson. “We bet on the people and the quality of the research and see what comes out of it over the longer term.” COMPANIES AND INSTITUTIONS MENTIONED Amgen Inc. (NASDAQ:AMGN), Thousand Oaks, Calif. Bristol-Myers Squibb Co. (NYSE:BMY), New York, N.Y. The Column Group, San Francisco, Calif. Constellation Pharmaceuticals Inc., Cambridge, Mass. Effector Therapeutics Inc., San Diego, Calif. Flexus Biosciences Inc., San Carlos, Calif. Genentech Inc., South San Francisco, Calif. Igenica Inc., Burlingame, Calif. Immune Design Corp. (NASDAQ:IMDZ), Seattle, Wash. Johnson & Johnson (NYSE:JNJ), New Brunswick, N.J. Merck & Co. Inc. (NYSE:MRK), Whitehouse Station, N.J. Neurona Therapeutics Inc., San Francisco, Calif. NGM Biopharmaceuticals Inc., South San Francisco, Calif. Nurix Inc., San Francisco, Calif. ORIC Pharmaceuticals Inc., San Francisco, Calif. Peloton Therapeutics Inc., Dallas, Texas Roche (SIX:ROG; OTCQX:RHHBY), Basel, Switzerland University of California San Francisco, San Francisco, Calif. REFERENCES Cukier-Meisner, E. “ARrangement for antagonism.” BioCentury (2013) Cukier-Meisner, E. “Less unSERDainty.” BioCentury (2014) McCallister, E. “Playing turnabout.” BioCentury (2010) 14 WEEK OF March 9, 2015 BIOCENTURY TOC