Metabolòmica Marta Cascante

Metabolòmica
Marta Cascante
Integrative Systems Biology, Metabolomics and Cancer lab
Department of Biochemistry and Molecular Biology
Institute of Biomedicine University of Barcelona (IBUB)
E-mail: [e-mail]
http://www.bq.ub.es/bioqint/arecerca.html

DNA
RNA
Protein
Biochemicals
(Metabolites)
Genomics
Transcriptomics
Metabolomics
Proteomics Proteins

SYSTEMS BIOLOGY
Cytomics
Genomics
Proteomics
Metabolomics
Information
Highest capacity to predict phenotype
Fluxomics
FROM MOLECULAR BIOLOGY TO SYSTEMS BIOLOGY

Metabolomics and fluxomics in the
systems Biology approach
-These networks are not independent but form “network of networks“
-Metabolic network crosstalk with other networks must be considered
in a systems biology approach
Driving force: Development of high-throughput data-collection techniques,
e.g. microarrays, protein chips, NMR, LC/MS-GC/MS….
allow to simultaneously interrogate all cell components
at any given time.
From molecules to networks:
transcription/regulatory network ...
- protein-protein interaction network
- signaling network
- metabolic network

Metabolites
Metabolites are not only the “end point” also the “driving force”?
Metabolomics and fluxomics in the systems
Biology approach
Gene
mRNA
Proteines
-Biological processes
regulation is a complex
phenomena more
“democratic” than
“hierarchical”
Central dogma of
molecular biology: