The Influence of Sleep on Cognition in Breast Cancer

The Influence of Sleep on
Cognition in Breast Cancer
Sonia Ancoli
-
Israel, PhD
Sonia Ancoli
Israel, PhD
Professor of Psychiatry and Medicine
U i it f C lif i S Di
U
n
i
vers
ity
o
f C
a
lif
orn
i
a
S
an
Di
e
g
o
Fatigue by Rodin
Supported by NIC CA112035, UL1RR031980 (CTRI),
UCSD Stein Institute for Research on Aging, the
Department of Veterans Affairs Center of Excellence for
Department of Veterans Affairs Center of Excellence for
Stress and Mental Health (CESAMH) and the UCSD
Moores Cancer Center

Cognitive Function
What Cancer Patients Say
What
Cancer
Patients
Say
“It's a fuzzy feeling, like trying to think through a
fog
Throw in a little bit of
exhaustion
and
fatigue
fog
.
Throw
in
a
little
bit
of
exhaustion
and
fatigue
,
and it doesn't leave you at your cognitive best. It's
hard to concentrate. It's a little bit like the feeling
y
ou
g
et when
y
ou've had one or two or drinks too
yg y
many, and you don't want to be drunk.”
Leroy Siever
“… 7
y
ears out of chemo treatments. I have been
y
telling my oncologist for years that I am still fogg
y
. I
am terrified that I might make a terrible mistake at
my job, so I live in constant fear and stress.”
ClS10
15
2007
C
aro
l
yn
S
.
10
-
15
-
2007
“Having just surpassed my 38 year old wife's two
year anniversary of discovering her cancer, we have
found that her chemo brain actually
worsened
as
found
that
her
chemo
brain
actually
worsened
as
the time from her treatments lengthened
Rick L. 11-06-2006
ICCTF International Cognition and Cancer ICCTF International Cognition and Cancer TaskTask Force Force ConferenceConference March 15March 15--17 17 thth 2012 2012 ––PARIS PARIS --FRANCEFRANCE

Inflammation
Depression
Poor Sleep/
Disrupted
Fatigue Circadian
Rhythms
Cancer;
Chemothera
py
Cognitive Deficit
py
ICCTF International Cognition and Cancer ICCTF International Cognition and Cancer TaskTask Force Force ConferenceConference March 15March 15--17 17 thth 2012 2012 ––PARIS PARIS --FRANCEFRANCE

JT075
C1W-1
07/25/03
07/26/03
C1W1
07/27/03
08/01/03
C1W2
08/02/03
08/03/03
08/08/03
08/09/03
C1W3
08/10/03
08/15/03
08/16/03
C4W1
08/17/03
10/03/03
10/04/03
C4W2
10/05/03
10/13/03
10/14/03
C4W3
10/15/03
10/19/03
10/22/03
ICCTF International Cognition and Cancer ICCTF International Cognition and Cancer TaskTask Force Force ConferenceConference March 15March 15--17 17 thth 2012 2012 ––PARIS PARIS --FRANCEFRANCE
0000 2400 24001200 1200
10/21/03

Rhythmicity Over Time with Chemotherapy
N=95; For comparisons
between each time point vs.
baseline:
*
p
< 05;
**
p
< 01;
baseline:
p
<
.
05;
p
<
.
01;
*** p < .001; **** p < .0001
**** **** *** ****
These data suggest that:
These data suggest that:
-the first administration of chemotherapy is associated with
transient circadian disruption
transient circadian disruption
-repeated administration of chemotherapy results in
progressively worse and more enduring rhythm impairments
ICCTF International Cognition and Cancer ICCTF International Cognition and Cancer TaskTask Force Force ConferenceConference March 15March 15--17 17 thth 2012 2012 ––PARIS PARIS --FRANCEFRANCE
Savard,J. et al. Sleep 32:1155-1160, 2009.
progressively worse and more enduring rhythm impairments
.