The Influence of Sleep on Cognition in Breast Cancer

The Influence of Sleep on

Cognition in Breast Cancer

Sonia Ancoli

-

Israel, PhD

Sonia Ancoli

Israel, PhD

Professor of Psychiatry and Medicine

U i it f C lif i S Di

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vers

ity

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f C

a

lif

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a

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an

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e

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Fatigue by Rodin

Supported by NIC CA112035, UL1RR031980 (CTRI),

UCSD Stein Institute for Research on Aging, the

Department of Veterans Affairs Center of Excellence for

Stress and Mental Health (CESAMH) and the UCSD

Moores Cancer Center

Cognitive Function

What Cancer Patients Say

What

Cancer

Patients

Say

“It's a fuzzy feeling, like trying to think through a

fog

Throw in a little bit of

exhaustion

and

fatigue

fog

.

Throw

in

a

little

bit

of

exhaustion

and

fatigue

,

and it doesn't leave you at your cognitive best. It's

hard to concentrate. It's a little bit like the feeling

y

ou

g

et when

y

ou've had one or two or drinks too

yg y

many, and you don't want to be drunk.”

Leroy Siever

“… 7

y

ears out of chemo treatments. I have been

y

telling my oncologist for years that I am still fogg

y

. I

am terrified that I might make a terrible mistake at

my job, so I live in constant fear and stress.”



ClS10

15

2007



C

aro

l

yn

S

.

10

-

15

-

2007

“Having just surpassed my 38 year old wife's two

year anniversary of discovering her cancer, we have

found that her chemo brain actually

worsened

as

found

that

her

chemo

brain

actually

worsened

as

the time from her treatments lengthened

Rick L. 11-06-2006

ICCTF International Cognition and Cancer ICCTF International Cognition and Cancer TaskTask Force Force ConferenceConference March 15March 15--17 17 thth 2012 2012 ––PARIS PARIS --FRANCEFRANCE

Inflammation

Depression

Poor Sleep/

Disrupted

Fatigue Circadian

Rhythms

Cancer;

Chemothera

py

Cognitive Deficit

py

ICCTF International Cognition and Cancer ICCTF International Cognition and Cancer TaskTask Force Force ConferenceConference March 15March 15--17 17 thth 2012 2012 ––PARIS PARIS --FRANCEFRANCE

JT075

C1W-1

07/25/03

07/26/03

C1W1

07/27/03

08/01/03

C1W2

08/02/03

08/03/03

08/08/03

08/09/03

C1W3

08/10/03

08/15/03

08/16/03

C4W1

08/17/03

10/03/03

10/04/03

C4W2

10/05/03

10/13/03

10/14/03

C4W3

10/15/03

10/19/03

10/22/03

ICCTF International Cognition and Cancer ICCTF International Cognition and Cancer TaskTask Force Force ConferenceConference March 15March 15--17 17 thth 2012 2012 ––PARIS PARIS --FRANCEFRANCE

0000 2400 24001200 1200

10/21/03

Rhythmicity Over Time with Chemotherapy

N=95; For comparisons

between each time point vs.

baseline:

*

p

< 05;

**

p

< 01;

baseline:

p

<

.

05;

p

<

.

01;

*** p < .001; **** p < .0001

**** **** *** ****

These data suggest that:

-the first administration of chemotherapy is associated with

transient circadian disruption

-repeated administration of chemotherapy results in

progressively worse and more enduring rhythm impairments

ICCTF International Cognition and Cancer ICCTF International Cognition and Cancer TaskTask Force Force ConferenceConference March 15March 15--17 17 thth 2012 2012 ––PARIS PARIS --FRANCEFRANCE

Savard,J. et al. Sleep 32:1155-1160, 2009.

progressively worse and more enduring rhythm impairments

.