Cognition and Cancer ICCTF Meetings Workshops Congres/Symposium
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Cognition and Cancer ICCTF Meetings Workshops 2003 : Benff (Canada) 2005 : Venice (Italy) 2008 : Amsterdam (Netherlands) Congres/Symposium 2010: New York (USA) 2012: Paris (France) ICCTF International Cognition and Cancer Task Force Conference March 15 15--17 th 2012 – PARIS - FRANCE 1 Meeting organized by North West Canceropole, INCa 7 Canceropoles Creation of the INCa 2003 (French National Cancer Inst) First Cancer plan (2003-2009) 6 operational programs with 70 measures 2nd National cancer plan (2009-2013) New programs and main areas Research and innovation, innovation Observation, Observation Prevention and screening ,Care , Life during and after cancer ICCTF International Cognition and Cancer Task Force Conference March 15 15--17 th 2012 – PARIS - FRANCE Research axis of the North West Canceropole 5 axis of research Development and validation prognostic and p predictive biomarkers to therapeutic p innovation Tumor onset and progression in malignant blood disorders Multimodality targeting in Oncology Cancer and neurosciences Cancer, individuals and society Multi-disciplinary flagships (from labs to bench) Development of integrated multidisciplinary research program of emerging topics : Cognition and cancer ICCTF International Cognition and Cancer Task Force Conference March 15 15--17 th 2012 – PARIS - FRANCE 2 ICCTF 2012 Organization Steering Committee Tim Alhes (NY, US) Sanne Schagen (Amsterdam, Netherlands) Janette Vardy (Sydney, Australia) Jeff Weffel (Houston, US) Organizing Committee Tim Alhes (NY, US) Sanne Schagen (Amsterdam, Netherlands) Janette Vardy (Sydney, Australia) Jeff Weffel (Houston, US) Florence JOLY (Caen, France) Advisory Board Patricia Ganz (Los Angeles, US) Ian Tannock (Toronto, Canada) Jimmie Holland (NY, US) Christina Meyer (Houston, US) Frits van Dam (Amsterdan, Netherlands) Paris local organization (Canceropole) Sophie Broutin (Lille France) Veronique Pancre (Lille France) Florence JOLY (Caen, France) ICCTF International Cognition and Cancer Task Force Conference March 15 15--17 th 2012 – PARIS - FRANCE 140 participants (ICCTF, Paris, 2012) USA France Netherlands Canada Belgium UK Australia Denmark Singapore Spain Germany Norway ICCTF International Cognition and Cancer Task Force Conference March 15 15--17 th 2012 – PARIS - FRANCE 3 Organization of the 3 days Late registrations Breaks, lunches on site (Espace St Martin) young g investigators g awards on Saturday y afternoon 2 y Boat cruise, Thursday evening 15th March MELODY BLUES - Quai de Bercy Aval - 75012 PARIS Departure by bus at 19h15 from Espace St Martin Return by bus at 22h30 to Espace St Martin ICCTF International Cognition and Cancer Task Force Conference March 15 15--17 th 2012 – PARIS - FRANCE Is Cancer and cognition a real problem nowadays? For the patients : definitely yes • 551 French and Belgian Patients • 41% complain of cognitive disorders with chemo • 72% consider it is a major side effect Hurricane Voice Breast Cancer Survey (2007) More than 2/3rd complain of cognitive disorders (Survey, Lefel at al, Submitted) Fatigue (62%) Treatment (45%) Memory dysfonction during and after CT 98% Negative impact on day to day lives 62% Anxiety, stress 26% ICCTF International Cognition and Cancer Task Force Conference March 15 15--17 th 2012 – PARIS - FRANCE 4 Is Cancer and cognition a real problem, nowadays? For the research scientific community 180 160 140 120 100 80 60 40 20 0 num publications 20022007 20082009 20102012 Pubmed : 302 Abstracts selected on words “cognition and cancer” in title and/or abstract between 2002-2012 Definitely yes ICCTF International Cognition and Cancer Task Force Conference March 15 15--17 th 2012 – PARIS - FRANCE Is Cancer and cognition a real problem, nowadays ? For the medical oncologists Yes but until now Yes, now, not definitely yes Why? Some doubts on the reality of the “chemobrain” They don’t have clear explanations on the mechanisms and which drugs may be involved Neuropsychological tests are difficult to organize in routine They have no solution to prevent and/or treat cognitive decline of their patients or to help them to cope with ICCTF International Cognition and Cancer Task Force Conference March 15 15--17 th 2012 – PARIS - FRANCE 5 What we already know Chemofog is a reality for breast cancer patients But not for all the patients Incidence : 30% (20 to 70) Moderate or subtle troubles (in most of the cases) Mains domains impaired Memory, concentration, information processing speed and executive functions No relationship p between objective j and subjective j disorders Chemotherapy agents already evaluated : MTX, 5FU and Alkylating agents ICCTF International Cognition and Cancer Task Force Conference March 15 15--17 th 2012 – PARIS - FRANCE What we have not yet already well known (1) Breast cancer Which groups of patients are at risks? Do cognition disorders improve overtime? What are the mains biological mechanisms involved? What about patients with other cancers? Affect cancer itself on cognitive functions? How to integrate all the different factors implicated ( (age, co- morbidities, biditi others th medications……) di ti ) ICCTF International Cognition and Cancer Task Force Conference March 15 15--17 th 2012 – PARIS - FRANCE 6 What we have not yet already well known (2) Impact of others chemotherapy agents or new targeted therapies? How to improve the cognitive problems and how to help patients to cope with them? ICCTF International Cognition and Cancer Task Force Conference March 15 15--17 th 2012 – PARIS - FRANCE Developments at the ICCTF meeting in Paris? Improvement of well design clinical trials Increase of clinical and research teams who work on the topic (75 abstracts) Well designed studies with longitudinal assessment and control groups Neuropsychological clinical trials Data on other tumor sites Colo-rectal, Hematology, Prostate, Head&neck, Kidney cancers, …. New data on others drugs (oxaliplatin, targeted therapies) ICCTF International Cognition and Cancer Task Force Conference March 15 15--17 th 2012 – PARIS - FRANCE 7 Developments at the ICCTF meeting in Paris? Neuropsychological clinical trials Influence of other factors than chemotherapy C ti l C Cortisol, Co morbidities, biditi age, sleep….. l Cultural representation of cognitive impairment New concepts (the impact of the cancer itself) First trials on cognitive rehabilitation ICCTF International Cognition and Cancer Task Force Conference March 15 15--17 th 2012 – PARIS - FRANCE Developments at the ICCTF meeting in Paris? Animal models +++ (17 abstracts) and biology Cancer itself Memory M and d age Mechanisms of brain injuries induced by oxaliplatin, docetaxel, targeted therapies (antiangiogenic and Mtor Inhibitors) Influence of other drugs than chemo on brains Corticoids, EPO, ……. Biology Cytokines, IL6 polymorphisms, APOE genotype, ……. ICCTF International Cognition and Cancer Task Force Conference March 15 15--17 th 2012 – PARIS - FRANCE 8 Developments at the ICCTF meeting in Paris? Imaging +++ (14 abstracts) fRMI Longitudinal studies, With control groups Cancer and treatments evaluations Long term impact of chemotherapy Pet-FDG ICCTF International Cognition and Cancer Task Force Conference March 15 15--17 th 2012 – PARIS - FRANCE Complexity of the process with multiple etiologies Multidisciplinary approach Inflammation Metabolism ne rotransmitters neurotransmitters V Vascular l d damage Hormones Neurogenesis Cognitive dysfunctions Chemotherapy Clinical approach Anemia Other medications Genes Emotional status Cancer Neuropsychological tests Neuro-imaging ICCTF International CognitionICCTF and Cancer Task Force Conference Modified from Wefel, 2010 Animals models March 15 15--17 th 2012 – PARIS - FRANCE 9 COGNITIVE FUNCTIONS AND CANCER A C ca research Clinical esea c - Cognitive functions - Fatigue - Quality of life C Experience of family and d friends fi d Longitudinal Studies North West Canceropole (since 2008) B Memory impairment Functional Imaging D Physiopathology Behavioural B h i l animal i l model Topics : Age, Chemotherapy, targeted therapies, compliance to oral treatment ICCTF International Cognition and Cancer Task Force Conference March 15 15--17 th 1 2012 – PARIS - FRANCE Multidisciplinary program on CANCER AND ADJUVANT CHEMOTHERAPY among elderly patients A Clinical Research - Cognitive function - Fatigue - Quality of life O l Oncology teams t Oncogeriatry teams Longitudinal studies COG‐AGE : Patients over 65 treated with adjuvant chemotherapy for breast cancer ICCTF International Cognition and Cancer Task Force Conference B Neuropsychological Evaluations and imaging C Animal models March 15 15--17 th 1 2012 – PARIS - FRANCE 10 What are the next steps? Multidisciplinary approach of cognition and cancer To learn from specialties other than cancer To share our experiences To identify the next steps for ICCTF meeting in 2014 To enjoy your stay in Paris ICCTF International Cognition and Cancer Task Force Conference March 15 15--17 th 2012 – PARIS - FRANCE ICCTF International Cognition and Cancer Task Force Conference March 15 15--17 th 2012 – PARIS - FRANCE 11 Good meeting ICCTF International Cognition and Cancer Task Force Conference March 15 15--17 th 2012 – PARIS - FRANCE 12
