Overview of Neuroimaging Studies

Overview of Neuroimaging Studies Overview of Neuroimaging Studies
in Evaluating the Postin Evaluating the Post--Chemo BrainChemo Brain
Overview of Neuroimaging Studies Overview of Neuroimaging Studies
in Evaluating the Postin Evaluating the Post--Chemo BrainChemo Brain
InternationalCognition&CancerTaskForceConferenceInternationalCognition&CancerTaskForceConference
1515‐‐17March201217March2012
DanSilverman,MD,PhDDanSilverman,MD,PhD
AhmansonTranslationalImagingDivisionAhmansonTranslationalImagingDivision
Dept.MolecularandMedicalPharmacologyDept.MolecularandMedicalPharmacology
UniversityofCalifornia,LosAngelesUniversityofCalifornia,LosAngeles
InternationalCognition&CancerTaskForceConferenceInternationalCognition&CancerTaskForceConference
1515‐‐17March201217March2012
DanSilverman,MD,PhDDanSilverman,MD,PhD
AhmansonTranslationalImagingDivisionAhmansonTranslationalImagingDivision
Dept.MolecularandMedicalPharmacologyDept.MolecularandMedicalPharmacology
UniversityofCalifornia,LosAngelesUniversityofCalifornia,LosAngeles

•Scope
•Differences in brain activation patterns
•Differences observed in chemo-exposed vs.
chemo-naivebrains at rest
•Mechanistic Considerations
•Potential Implications for Clinical Decisions
•Scope
•Differences in brain activation patterns
•Differences observed in chemo-exposed vs.
chemo-naivebrains at rest
•Mechanistic Considerations
•Potential Implications for Clinical Decisions
Studies of the PostStudies of the Post--Chemo BrainChemo Brain

Imaging studies of regional cerebral Imaging studies of regional cerebral
function after chemotherapy by function after chemotherapy by
structural and functional neuroimaging structural and functional neuroimaging
modalities, with focus upon:modalities, with focus upon:
* human brain, * human brain,
* data published in peer* data published in peer--reviewed literature reviewed literature
Imaging studies of regional cerebral Imaging studies of regional cerebral
function after chemotherapy by function after chemotherapy by
structural and functional neuroimaging structural and functional neuroimaging
modalities, with focus upon:modalities, with focus upon:
* human brain, * human brain,
* data published in peer* data published in peer--reviewed literature reviewed literature
Studies of the PostStudies of the Post--Chemo Brain: Chemo Brain:
ScopeScope

•Scope
•Differences in brain activation patterns
•Differences observed in chemo-exposed vs.
chemo-naivebrains at rest
•Mechanistic Considerations
•Potential Implications for Clinical Decisions
•Scope
•Differences in brain activation patterns
•Differences observed in chemo-exposed vs.
chemo-naivebrains at rest
•Mechanistic Considerations
•Potential Implications for Clinical Decisions
Studies of the PostStudies of the Post--Chemo BrainChemo Brain

LongLong--term memoryterm memory
recall taskrecall task
Baseline Baseline
control control
tasktask
(read, repeat)(read, repeat)
ShortShort--term term
memorymemory
recall taskrecall task
Resting Resting
metabolismmetabolism
12 min.12 min. 12 min.12 min.
LongLong--term memoryterm memory
recall taskrecall task
12 min.12 min.
ShortShort--term term
memorymemory
recall taskrecall task
12 min.12 min.
Inject 15O-water
2 min scan
Inject 15O-water
2 min scan
Baseline Baseline
control control
tasktask
(read, repeat)(read, repeat)
Inject 18FDGInject 18FDG
Inject 15O-water
2 min scan
Inject 15O-water
2 min scan
Inject 15O-water
2 min scan
Inject 15O-water
2 min scan
Inject 15O-water
2 min scan
Inject 15O-water
2 min scan
Inject 15O-water
2 min scan
Inject 15O-water
2 min scan
Inject 15O-water
2 min scan
Inject 15O-water
2 min scan
12 min.12 min.
45 min. uptake45 min. uptake
30 min scan30 min scan
PETScanProtocol