coming to start at lower
dose (dose level -1)
• IND165: This is a phase 2
study. It showed more
fever, rigor and chills with
OGX-011. PSA progression
is significantly less in
combination arm (OGX-011
and docetaxel). A new
phase 3 trial is being
planned for overall survival.
• IND195: new trial coming
up. SB939 is an oral
histone deacetylase
(HDAC) inhibitor.
Circulating tumor cell (CTC)
will be done for this trial.
Breast Trials
• MA32. Use metformin 1700
mg po versus placebo as
adjunct for early adjuvant
Breast Cancer Patient
(within 4 years). It has been
show insulin might affect
cancer prognosis in the first
5 years. Therefore, the
study duration is for 5
years. Metformin can
reduce insulin usage by 25
to 33% within the first few
days. It has potential for
cancer treatment in two
ways; 1. thru liver to reduce
insulin; 2. act in tumor cells
via the mTOR pathway.
Sample size is 3582. It
might be OK to be on this
trial if patients are on other
clinical trials.
• MA27: exemestane versus
anastrozole to test two
issues. Potency with all the
aromatase inhibitors and if
there is a difference
between steroid AI and
non-steroid AI. Futility
analysis will be done for
this study. A futility analysis
is a calculation made
during the course of a trial
of the probability that the
trial will produce helpful
results. A trial is judged
futile if the probability is too
small.
• Correlative studies:
biomarker may help us
better understand how
individual cancer might
respond to treatment.
• Circulating tumour cells:
This is not a new concept.
It was discovered 100
years ago, but poorly
understood. There are
questions regarding if CTC
has metastatic potential,
i.e., breast cancer CTC can
circulate for years. There is
also evidence that CTC
might have prognostic
significance. Currently, only
one FDA approved system,
cell search system, to
measure CTC. Dr. Chi in
our center had purchased
one. However, the test is
not as sensitive as some of
the other tests.
Kathy Lebreux
Pharmacy Research
Technician
The Ottawa Hospital Cancer
Centre
My position at The Ottawa
Hospital Cancer
Centre(TOHCC), one of 3
Pharmacy Research
Technicians, is an important
part of the Clinical Trial team.
Attending the NCIC meeting
for the 1st time provided me
with a more complete picture
of the Clinical Trial process
and specifically how NCIC
trials operate.
I attended a variety of
disease site meetings and
lectures over the 3 days. I
found the CTG Pharmacists
Network meeting very
interesting and I was able to
take part in a conversation
regarding drug receipt and
Lot# procedures. I learned a
few helpful tools in the Stress
and Time Management
workshop which I brought
back to work with me and
shared with my colleagues. A
highlight of my weekend was
listening to Dr. Frances
Shepherd’s excellent Crosbie
Lecture on “Lung Cancer: A
Journey from Nihilism to
Hope Through Bench to
Bedside Research.”
Through networking at this
meeting and previous
Investigator meetings that I
have attended, I have come
to realize that the role of
Pharmacy Research
Technicians working in
Clinical Trials at TOHCC has
been expanded to a wide
scope of practice.
In the future I would be very
interested in becoming a
member of the Pharmacist
Network Group if there would
be an opening for a
Pharmacy Research
Technician within the group. I
would be happy to share any
information about the role of
Pharmacy Research
Technicians at our centre if
any other cancer centres are
considering expanding the
duties of their Pharmacy
Technicians.
I would like to thank the
CAPhO executives and
awards chair for selecting my
application for the sponsored
Travel Grant. I thoroughly
enjoyed the Spring NCIC
meeting and hope to be able
to attend future NCIC
meetings as well.