CAPhO Oncology Fundamentals Day
Saturday, October 1, 2016
Page | 4 #OFD16 www.capho.org
Chronic Leukemias - Danica Wasney, CancerCare Manitoba, Winnipeg, MB
Systemic therapy for both Chronic Lymphocytic Leukemia (CLL) and Chronic Myelogenous
Leukemia (CML) has evolved significantly over the past 10-15 years. Systemic therapy for
both CLL and CML is complex due to both the regimens used and the patient populations,
as patients often present with comorbidities and multiple medications. Pharmacists are well
equipped to optimize clinical outcomes for patients with CLL and CML through education,
monitoring, symptom management, and medication management.
For CLL, selection of systemic therapy is based on a variety of patient and disease factors,
including staging, patient performance/functional status, and genetic markers. Systemic
therapy regimens for CLL are complex, consisting of both oral and parenteral anticancer
agents in addition to crucial supportive care agents. In addition, these regimens require
careful attention with regards to drug interactions and medication adherence. Pharmacists
can play a key role in optimizing care for patients with CLL.
For CML, the introduction of targeted therapies has resulted in significant advances in
patient survival and outcomes. Treatment selection is based on a variety of patient and
disease factors, including CML phase, patient performance/functional status, and genetic
markers. Since systemic therapies used to manage CML are usually orally administered on
an outpatient basis, pharmacists are positioned to support patients with CML through
management of drug interactions, symptom management, and medication adherence.
Learning Objectives:
After this presentation, participants should be able to:
1. Discuss the incidence, prevalence, pathophysiology, and staging for Chronic
Lymphocytic Leukemia (CLL);
2. Discuss the incidence, prevalence, pathophysiology, and staging (phases) for
Chronic Myelogenous Leukemia (CML);
3. Describe systemic treatment selection, monitoring parameters, and expected
outcomes for patients with CLL and CML; and
4. Explain common supportive care issues for patients with CLL and CML.
Danica Wasney is a Clinical Pharmacist for the Provincial Oncology
Drug Program at CancerCare Manitoba. In this role, she participates
in the provincial oncology drug review process including the
management of the provincial oncology drug formulary. She is a
member of the Expert Review Committee for the pan-Canadian
Oncology Drug Review (pCODR) at the Canadian Agency for Drugs
and Technologies in Health (CADTH).
Danica has clinical experience in breast, colorectal, thoracic and gynecologic cancers,
neuro-oncology, and hematologic malignancies.