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Canadian OnCOlOgy nursing JOurnal • VOlume 26, issue 3, summer 2016
reVue Canadienne de sOins infirmiers en OnCOlOgie
FEATURES/RUbRiqUES
leADersHiP cOluMN
Medication errors and shift to a culture of patient
safety and high reliability
by Janice Chobanuk
Medication errors with antineoplastic
drugs can be disastrous to patients
due to the drugs’ high toxicity and lim-
ited therapeutic index. Cancer patients
often require numerous complex and
often toxic therapies for treatment, which
requires careful coordination of care. In a
study involving 6,607antineoplastic pre-
scriptions, the researchers found an error
rate of 5.2% (449). The highest errors
were prescription errors (91%), followed
with pharmaceutical (8%) and adminis-
tration errors (1%). The researchers esti-
mated that 13.4% of these errors would
have resulted in a patient injury, 2.6%
in permanent damage, and 2.6% would
have aected the prognosis of the cancer
patient. Gandhi et al. (2005) found the
chemotherapy error rate was 3% in 3,200
chemotherapy orders for adult and pediat-
ric patients. In a study involving pediatric
and adult oncology patients, the authors
found chemotherapy errors were 0.3 to
5.8 per 100visits(Walsh etal., 2009).
Many oncology-nursing leaders are
recognizing the importance of treating
chemotherapy as a high-risk activity.
Nursing leaders are actively promot-
ing transition to a patient safety and
high-reliability culture in order to
enhance patient safety in oncology set-
tings (Ranchon etal., 2012). This para-
digm shift requires strong leadership
support, the use of principles of high
reliability and a patient-centric focus,
as well as continuous quality improve-
ment initiatives. The strategy involves
leaders addressing issues such as inher-
ent weaknesses in processes in the can-
cer setting, clinical designs of buildings,
the impact of computer programs, sta-
ing levels, equipment issues, and other
factors that inuence the local working
conditions. A focus on safety requires
oncology leaders to move away from
reactive responses to error reports,
and reviewing individual actions and
the error, to embrace a proactive sys-
tem-wide preventative approach.
Globally, leaders in health care facilities
are starting to incorporate the exper-
tise and lessons learned from high-
risk groups with low failure rates, such
as aviation and nuclear power plants,
into their safety strategic approach
(Ranchon et al., 2012). These organiza-
tions have developed an array of tools
for assessing organizational factors that
have the potential to lead to a failure or
error. The tools address issues such as
supervision, planning, communication,
training, and maintenance. Instead of a
retrospective analysis of adverse events,
these tools enable oncology leaders to
transition to a more proactive culture of
patient safety and monitor safety trends
in the organization on a continual basis.
Chemotherapy management is a
hazardous and challenging procedure
that oncology leaders need to recog-
nize as a high-risk activity. Mistakes can
occur any time and at any stage in the
process—from the prescription, prepa-
ration, and dispensing to the adminis-
tration. The increasing number of oral
chemotherapy agents adds a new chal-
lenge for oncology facilities. Shah et al.
(2016) reported that 22 interventions
(35%) were required to prevent poten-
tial errors in 63 oral medication orders
over a seven-month period. Most of the
errors were related to dosage adjust-
ment, the identication of interacting
drugs, and additional drug monitoring.
Oncology nursing leaders are well
positioned to drive a culture shift to
patient safety and high reliability. This
change involves tactical strategies such
as education, safety committees, safety
protocols and procedures, use of tech-
nology, a no blame atmosphere, and
a focus on zero medication errors
(Ranchon, McEachan, Giles, Sirriyeh,
Watt, & Wright, 2012). Other examples
of initiatives include independent double
checks, bar codes, electronic order-en-
try systems with decision support, and
smart pump technology. Oncology nurs-
ing leaders need to be actively engaged
in patient safety improvement to impact
on patients, employees, physicians, and
other clinicians in the organization.
reFereNces
Gandhi, T.K., Bartel, S.B., Shulman, L.N.,
Verrier, D., Burdick, E., Cleary, A., …
Bates,D.W. (2005). Medication safety in the
ambulatory chemotherapy setting. Cancer,
104, 2477–2483. doi:10.1002/cncr.21442
Ranchon, F., Salles, G., Späth, H.,
Schwiertz, V., Vantard, N., Parat, S., …
Rioufol, C. (2011). Chemotherapeutic
errors in hospitalised cancer patients:
Attributable damage and extra
costs. BMC Cancer, 111(478), 2–10.
doi:10.1186/1471-2407-11-478
Ranchon, L., McEachan, R.C., Giles, S.J.,
Sirriyeh, R., Watt, I.S., & Wright, J.
(2012). Development of an evidence-
based framework of factors contributing
to patient safety incidents in hospital
settings: A systematic review. BMJ
Quality and Safety, 21(5), 369–380.
doi:10.1136/bmjqs-2011-000443
Shah, N.N., Casella, E., Capozzi, D.,
McGettigan, S., Gangadhar, T.C.,
Schuchter, L., & Myers, J.S. (2016).
Improving the safety of oral
chemotherapy at an academic medical
center. Journal of Oncology Practice, 12(1),
71–76. doi:10.1200/JOP.2015.007260
Walsh, K.E., Dodd, K.S., Seetharaman, K.,
Roblin, D.W., Herrinton, L.J.,
Worley, A.V., … Gurwitz, J.H. (2009).
Medication errors among adults
and children with cancer in the
outpatient setting. Journal of Clinical
Oncology, 27(6), 891–896. doi:10.1200/
JCO.2008.18.6072
AbOut tHe AutHOr
Janice Chobanuk, BScN, MN,
CHPCN(C), CON(C), Director
Ambulatory Care and Systemic
Therapy, Community Oncology,
Alberta Health Services,
CancerControl Alberta
Edmonton, Alberta