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Biology, Cancer, Genetics and Epigenetics
UMR3664 - Nuclear Dynamics
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 UMR3664 - Nuclear Dynamics

UMR3664 – Nuclear Dynamics
PARTAGER
 Presentation of the unit
Unit DirectorAngela Taddei Unit Deputy DirectorNathalie Dostatni
Teams in this unit investigate the mechanisms underlying the
stability and the plasticity of genetic and epigenetic information in
normal or pathological contexts such as cancer. Using
complementarity approaches, we develop an integrated view of the
functional organization of the genome at different scales: from the
molecule to the cell to the organism.
Using several model organisms (Drosophila, Xenopus, mouse, yeast) and cell lines (human, rodents, insects
…) we study fundamental processes of chromosome biology: DNA replication, segregation and repair,
regulation of gene expression during development, cell cycle and in response to environmental stress
Together, these models are helping to decipher how DNA replication and repair, gene transcription and
silencing are modulated during development, cell division and in response to environmental stress
The main research themes of the unit include:
 The roles of factors involved in chromatin dynamics, genome stability and repair
 How functional domains of eukaryotic genomes are established and then maintained during development.
 How epigenetic plasticity plays a part in controlling the polarity of the embryo.
 How nuclear compartmentalisation and dynamics participate in regulating various functions of the genome.
Key publications

Year of publication 2016
Sebastian Müller, Geneviève Almouzni (2016 Dec 1)
Chromatin dynamics during the cell cycle at centromeres.
Nature Reviews Genetics : 192-208 : DOI : 10.1038/nrg.2016.157
Christèle Maison, Delphine Bailly, Jean-Pierre Quivy, Geneviève Almouzni (2016 Jul 19)
The methyltransferase Suv39h1 links the SUMO pathway to HP1α marking at pericentric
heterochromatin.
Nature communications : 12224 : DOI : 10.1038/ncomms12224
Lisa Prendergast, Sebastian Müller, Yiwei Liu, Hongda Huang, Florent Dingli, Damarys Loew, Isabelle
Vassias, Dinshaw J Patel, Kevin F Sullivan, Geneviève Almouzni (2016 Jun 11)
The CENP-T/-W complex is a binding partner of the histone chaperone FACT.
Genes & development : 1313-26 : DOI : 10.1101/gad.275073.115
A Coulon, D R Larson (2016 Jun 1)
Fluctuation Analysis: Dissecting Transcriptional Kinetics with Signal Theory.
Methods in enzymology : 159-91 : DOI : 10.1016/bs.mie.2016.03.017
Year of publication 2015
Tineke L Lenstra, Antoine Coulon, Carson C Chow, Daniel R Larson (2015 Nov 10)
Single-Molecule Imaging Reveals a Switch between Spurious and Functional ncRNA
Transcription.
Molecular cell : 597-610 : DOI : 10.1016/j.molcel.2015.09.028
Micol Guidi, Myriam Ruault, Martial Marbouty, Isabelle Loïodice, Axel Cournac, Cyrille Billaudeau, Antoine
Hocher, Julien Mozziconacci, Romain Koszul, Angela Taddei (2015 Apr 2)
Spatial reorganization of telomeres in long-lived quiescent cells.
Genome biology : 206 : DOI : 10.1186/s13059-015-0766-2
 Presentation of the unit
News
07/02/2017 Chromatin dynamics during the cell cycle at centromeres Epigenetic : new
publication in Nature Reviews Genetic. The team Chromatin dynamics (CNRS/Institut Curie)
highlight highlight centromeric chromatin dynamics during the different phases of the cell cycle.
“Centromeric chromatin undergoes major changes...
Teams
 Team Almouzni
 Team Coulon
 Team Dostatni
 Team Drinnenberg
 Team Taddei