Skip to content Centre de recherche de l'Institut Curie Research Center Search for: Donate fr en Research BIOLOGY & CHEMISTRY OF RADIATIONS, CELL SIGNALING AND CANCER BIOLOGY, CANCER, GENETICS AND EPIGENETICS INTEGRATIVE TUMOUR BIOLOGY, IMMUNOLOGY AND ENVIRONMENT MULTISCALE PHYSICS-BIOLOGY-CHEMISTRY AND CANCER DEPARTMENT OF TRANSLATIONAL RESEARCH SIRIC IPGG LABEX CELTISPHYBIO LABEX DEEP Platforms Bioinformatics platform BioPhenics Cell & Tissue Imaging Chemical Library Cytometry : cell sorting & analysis Experimental Radiotherapy Flow Cytometry Genomics In vivo experiments Mass Spectrometry and Proteomics Facility Next Generation Sequencing Pre-clinical investigation laboratory (LIP) Protein Expression and Purification Core Facility Reverse Phase Protein Array Synthetic Genetic Array (SGA) Therapeutic antibodies (Tab-IP) and recombinant antibodies Training Jobs About us All teams Biology, Cancer, Genetics and Epigenetics UMR3664 - Nuclear Dynamics Home Research Biology, Cancer, Genetics and Epigenetics UMR3664 - Nuclear Dynamics UMR3664 – Nuclear Dynamics PARTAGER Presentation of the unit Unit DirectorAngela Taddei Unit Deputy DirectorNathalie Dostatni Teams in this unit investigate the mechanisms underlying the stability and the plasticity of genetic and epigenetic information in normal or pathological contexts such as cancer. Using complementarity approaches, we develop an integrated view of the functional organization of the genome at different scales: from the molecule to the cell to the organism. Using several model organisms (Drosophila, Xenopus, mouse, yeast) and cell lines (human, rodents, insects …) we study fundamental processes of chromosome biology: DNA replication, segregation and repair, regulation of gene expression during development, cell cycle and in response to environmental stress Together, these models are helping to decipher how DNA replication and repair, gene transcription and silencing are modulated during development, cell division and in response to environmental stress The main research themes of the unit include: The roles of factors involved in chromatin dynamics, genome stability and repair How functional domains of eukaryotic genomes are established and then maintained during development. How epigenetic plasticity plays a part in controlling the polarity of the embryo. How nuclear compartmentalisation and dynamics participate in regulating various functions of the genome. Key publications Year of publication 2016 Sebastian Müller, Geneviève Almouzni (2016 Dec 1) Chromatin dynamics during the cell cycle at centromeres. Nature Reviews Genetics : 192-208 : DOI : 10.1038/nrg.2016.157 Christèle Maison, Delphine Bailly, Jean-Pierre Quivy, Geneviève Almouzni (2016 Jul 19) The methyltransferase Suv39h1 links the SUMO pathway to HP1α marking at pericentric heterochromatin. Nature communications : 12224 : DOI : 10.1038/ncomms12224 Lisa Prendergast, Sebastian Müller, Yiwei Liu, Hongda Huang, Florent Dingli, Damarys Loew, Isabelle Vassias, Dinshaw J Patel, Kevin F Sullivan, Geneviève Almouzni (2016 Jun 11) The CENP-T/-W complex is a binding partner of the histone chaperone FACT. Genes & development : 1313-26 : DOI : 10.1101/gad.275073.115 A Coulon, D R Larson (2016 Jun 1) Fluctuation Analysis: Dissecting Transcriptional Kinetics with Signal Theory. Methods in enzymology : 159-91 : DOI : 10.1016/bs.mie.2016.03.017 Year of publication 2015 Tineke L Lenstra, Antoine Coulon, Carson C Chow, Daniel R Larson (2015 Nov 10) Single-Molecule Imaging Reveals a Switch between Spurious and Functional ncRNA Transcription. Molecular cell : 597-610 : DOI : 10.1016/j.molcel.2015.09.028 Micol Guidi, Myriam Ruault, Martial Marbouty, Isabelle Loïodice, Axel Cournac, Cyrille Billaudeau, Antoine Hocher, Julien Mozziconacci, Romain Koszul, Angela Taddei (2015 Apr 2) Spatial reorganization of telomeres in long-lived quiescent cells. Genome biology : 206 : DOI : 10.1186/s13059-015-0766-2 Presentation of the unit News 07/02/2017 Chromatin dynamics during the cell cycle at centromeres Epigenetic : new publication in Nature Reviews Genetic. The team Chromatin dynamics (CNRS/Institut Curie) highlight highlight centromeric chromatin dynamics during the different phases of the cell cycle. “Centromeric chromatin undergoes major changes... Teams Team Almouzni Team Coulon Team Dostatni Team Drinnenberg Team Taddei Platforms Plateforme SGA EXPORTER LA PAGE EN PDF The sites of the Institut curie curie.fr protontherapie.curie.fr enseignement.curie.fr cancersdusein.curie.fr musee.curie.fr unejonquillepourcurie.fr radio.curie.fr Sitemap Contact Legals INSTITUT CURIE, 26 rue d’Ulm, 75248 Paris Cedex 05, France CENTRE DE RECHERCHE Paris +33 (0) 1 56 24 55 00 Orsay +33 (0) 1 69 86 30 00 Coming to the Institut Curie