CANCEROLOGY AT UCL

CANCEROLOGY AT UCL
2004
Edited by D. Opfergelt (UCL ADRE) Dec. 2004
With the contribution of : O.Tirions, M. Plevoets, A. Distelmans, F. Kinard and N. Burteau
Cover : “Acute myeloblastic leukaemia” (Bone marrow aspirate stained by the May-Grünwald/Giemsa technique;
original magification : 460X)
Hematology unit, St Luc Hospital - Prof. Jean-Marie Scheiff
This booklet “Cancerology at UCL” has been implemented by the Research
Administration of the Université catholique de Louvain (UCL) under the
supervision of Professor Pierre Scalliet, President of the Cancer Center of the
academic hospital, Professor and Head of department of the Radiation
Oncology Unit of UCL.

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UNIVERSITÉ CATHOLIQUE DE LOUVAIN - CANCEROLOGY AT UCL
Foreword
Besides the fact of being a public health problem of first order, cancer is a complex pathology which study requests
the collaboration of all the scientific disciplines. By essence, oncology is an “interdisciplinary” field because of the
interaction between specialists in the design and implementation of complex sequences of research and care : surgery,
drug, therapy, radiotherapy, rehabilitation, etc.
Many research projects performed at the Université catholique de Louvain and specially on its biomedical campus in
Brussels, are part of international networks.
This booklet presents the topics of interest, recent achievements and current developments of research teams
involved in cancerology. These topics are classified in nine categories, according to the main scientific or technological
approaches.
The last part gathers the different research centers and non profit associations established on the UCL campus and
devoted to cancer.
◗PREVENTION AND EPIDEMIOLOGY
◗MECHANISMS OF CANCER
◗ DIAGNOSTICS :
immunology - genetics
imaging
◗TREATMENT :
clinical studies
anti-cancer treatment
surgery
radiotherapy
◗PSYCHO-ONCOLOGY
◗RESEARCH CENTERS AND NON PROFIT ASSOCIATIONS
The main objective of this document is to catalyze the development of scientific research, to promote
synergies and to enrich the partnerships so as to develop the scientific assets an the industrial level and by
the way, improve the quality health care.

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UNIVERSITÉ CATHOLIQUE DE LOUVAIN - CANCEROLOGY AT UCL
Content
A - PREVENTION AND EPIDEMIOLOGY
A.1 - Risk assessment of carcinogenic
chemicals
ALFRED BERNARD
A.2 - Early detection and prevention of post
transplant lymphoproliferative diseases
ETIENNE SOKAL, DOMINIQUE LATINNE, PATRICK GOUBAU, MONIQUE
BODEUS, BENOÎT KABAMBA MUKADI, YANNICK NIZET, FRANÇOISE SMETS
A.3 - Chemoprevention in liver cancer
YVES HORSMANS
A.4 - Methodological support in epidemiology
and biostatistics applied to research in cancer
ANNIE ROBERT, RENÉ TONGLET
A.5 - Genetic profile of breast cancers : implication
in preventive and predictive medicine.
CATHERINE E.T.SIBILLE, MARTINE BERLIÈRE, CHRISTINE GALANT
B - MECHANISMS OF CANCER
B.1 - Regulation of membrane trafficking and
motility by oncogenes
PIERRE COURTOY
B.2 - Mechanisms that regulate the migration of
brain cells in vitro and in vivo
ANDRÉ M. GOFFINET
B.3 - Cytogenetic and molecular characterization
of T-cell proliferation in hypereosinophilic
patients.
CATHERINE E.T. SIBILLE
B.4 - Identification of human tumor-specific
antigens
THIERRY BOON, PIERRE VAN DER BRUGGEN, BENOÎT VAN DEN
EYNDE, PIERRE COULIE, ETIENNE DE PLAEN, BERNARD LETHE,
ALINE VAN PEL, CHRISTOPHE LURQUIN, FRANCIS BRASSEUR,
DANIÈLE GODELAINE
B.5 - Analysis of the intracellular processing
of tumor antigens recognized by cytolytic
T lymphocytes
BENOÎT VAN DEN EYNDE
B.6 - Mechanisms of tumor resistance to the immune
system and development of a mouse model of
inducible melanoma
BENOÎT VAN DEN EYNDE
B.7 - Aristolochic acid and ochratoxin A : etiological
factors of Balkan endemic nephropathy and
associated urothelial tumors
JEAN-PIERRE COSYNS
B.8 - AMP-activated protein kinase, a new potential
regulator of cytoskeleton organization : role in cell
proliferation and/or differentiation.
LOUIS HUE, MARK RIDER
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B.9 - Mammalian antioxidant enzymes
BERNARD KNOOPS, JEAN-PAUL DECLERCQ, JEAN-FRANÇOIS REES
B.10 - Mechanisms involved in apoptosis induced
by anticancerous drugs
MARIE-PAULE MINGEOT-LECLERCQ
B.11 - Hox transcription factors and cancer
RENÉ REZSOHAZY
◗DIAGNOSTICS
C. IMMUNOLOGY – GENETICS
C.1 - Genetic analysis of brain tumours
MIIKKA VIKKULA, CATHERINE GODFRAIND
C.2 - Characterization of malignant hemopathies
by molecular and flow cytometry
DOMINIQUE LATINNE, JEAN-LUC VAERMAN, VÉRONIQUE DENEYS
C.3 - Assays of tumor markers
MARIANNE PHILIPPE, PHILIPPE DE NAYER
C.4 - Characterization of acute leukemias by gene
expression analysis : comparison of molecular and
immunological approaches ; impact on diagnosis
and prognosis.
PASCALE SAUSSOY, DOMINIQUE LATINNE, AUGUSTIN FERRANT
C.5 - Immunodiagnosis of paraneoplastic
neurological disorders
CHRISTIAN SINDIC
C.6 - Development of new molecular based
diagnostic strategies in prostate cancer.
BERTRAND TOMBAL, JEAN LUC GALA
◗DIAGNOSTICS
D. IMAGING
D.1 - Rigid registration of PET, CT and
MR modalities for radiotherapy planning and
dense deformation field estimation for brain
intra-operative images registration
BENOÎT MACQ
D.2 - Functional magnetic resonance (NMR, EPR)
spectroscopy and imaging in tumors
BERNARD GALLEZ
D.3 - Anatomic and functional imaging of liver
tumors
BERNARD VAN BEERS
◗ TREATMENT
E. CLINICAL STUDIES
E.1 - Academic clinical trials in medical
oncology
JEAN-PASCAL MACHIELS, JEAN-FRANÇOIS BAURAIN
E.2 - Clinical studies in hematology
AUGUSTIN FERRANT, LUCIENNE MICHAUX, ERIC VAN DEN NESTE
E.3 - Clinical studies in hematology :
Multiple myeloma, Hodgkin’s lymphoma
AUGUSTIN FERRANT, LUCIENNE MICHAUX, ERIC VAN DEN NESTE
F. ANTI-CANCER TREATMENT
F.1 - Therapeutic vaccination of cancer patients
with tumor specific antigens
THIERRY BOON, MARIE MARCHAND, NICOLAS VAN BAREN
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UNIVERSITÉ CATHOLIQUE DE LOUVAIN - CANCEROLOGY AT UCL
F.2 - Isolation and structure determination of
active compounds from plants used in traditional
medicine to treat different forms of cancers.
Analysis of the mode of action.
JOËLLE QUETIN-LECLERCQ
F.3 - The tumor vascularity : bases for adjuvant
strategies to conventional anti-tumor treatments
and anti-angiogenic approaches.
OLIVIER FERON
F.4 - Phase II study of utilisation of a recombinant
chimeric protein in patients with recurrent
progressive glioblastoma
CHRISTIAN RAFTOPOULOS
F.5 - Cancer immunotherapy-clinical trials
JEAN-FRANÇOIS BAURAIN, JEAN-PASCAL MACHIELS
F.6 - Lung cancer - mesothelioma -
clinical research in diagnosis - active treatment -
supportive care
DANIEL RODENSTEIN, PHILIPPE COLLARD, GIUSEPPE LIISTRO,
THIERRY PIETERS
F.7 - Development of new calcium-based strategies
to induce apoptotic cell death in prostate cancer
cell lines.
BERTRAND TOMBAL, PHILIPPE GAILLY
F.8 - Breast cancer
JACQUES DONNEZ, MARTINE BERLIERE, JEAN-LUC SQUIFFLET,
ISABELLE LECONTE, LATIFA FELLAH, CHRISTINE GALANT, CATHERINE
SIBILLE, BÉNÉDICTE BAYET
◗ TREATMENT
G. SURGERY
G.1 - Cryopreservation of ovarian cortex removed
before chemotherapy allows the restoration of
ovarian function after orthotopic
autotransplantation
JACQUES DONNEZ, JEAN-LUC SQUIFFLET, PASCALE JADOUL,
CÉLINE PIRARD, CHRISTINE WYNS, DOMINIQUE DEMYLLE, MARIE-
MADELEINE DOLMANS, BELEN MARTINEZ-MADRID,
ANNE VAN LANGENDONCKT
G.2 - Limb salvage in tumor surgery with massive
bone allografts
CHRISTIAN DELLOYE, OLIVIER CORNU, XAVIER BANSE
◗ TREATMENT
H. RADIOTHERAPY
H.1 - Biological dosimetry and radiobiological
calibration of clinical hadron beams
JOHN GUEULETTE
H.2 - Radiobiology of light ions
ANDRÉ WAMBERSIE
H.3 - Molecular imaging for radiotherapy
VINCENT GRÉGOIRE
H.4 - Treatment planning of intensity modulated
radiotherapy (IMRT) for head and neck cancer :
optimization of the treatment technique
and validation by measurements and
Monte Carlo simulations
MILÀN TOMSEJ, NATHALIE DE PATOUL, STEFAAN VYNCKIER,
VINCENT GRÉGOIRE
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