GINEGEPS GINECO Group on Early Phase Studies

J GINECO B You Mars 2016
GINEGEPS
GINECO Group on Early
Phase Studies
Dr Benoit You, MD PhD
GINECO-GINEGEPS
Institut de Cancérologie des Hospices Civils de Lyon
Centre d'Investigation de Thérapeutiques en Oncologie et
Hématologie de Lyon (CITOHL)
EMR UCBL/HCL 3738

J GINECO B You Mars 2016
GINEGEPS team
Alexandra Leary
(Institut Gustave Roussy, Paris)
Olivier Tredan
(Centre Léon Bérard, Lyon)
Thibault de la Motte Rouge
(CLCC, Rennes)
Pierre Etienne Heudel
(Centre Léon Bérard, Lyon)
Manuel Rodriguez
(Institut Curie, Paris)
Etienne Rouleau
(Institut Curie, paris)
Pierre Combe
(HEGP, Paris)
CELLULAR
/MOLECULAR
BIOLOGY
(signalling
pathways,
apoptosis,
sequencing,
biobanking,
oncogenetics,
immunology …)
Jean Sebastien Frenel
(Institut de la Loire, Nantes)
Philippe Follana
(Centre Lacassagne, Nice)
CIRULATING TUMOR
MARKERS
(CTCs, circulating
tumor nucleic acids)
Audrey Dugué
(Centre F Baclesse, Caen)
Supervision de D Pérol
(Centre Léon Bérard)
Julien Péron
(Institut de cancérologie
HCL)
STATISTICS
Benoit You
(Institut de cancérologie HCL,
Lyon)
PHARMACOLOGY
(PK, modeling)
Laure Fournier
(APHP, Paris)
Nicolas Aide
(Centre F Baclesse, Caen)
IMAGING
(perfusion CT-scanner,
DCE-MRI, PET- CT
scanner)
GINEGEPS
Pierre Alexandre Just
(Hopital Cochin, Paris)
Sabrina Croce
(Instuut Bergonie, Bordeaux)
PATHOLOGY
(tumor banking)
Elisabeth Chereau
(Institut Paoli Calmette, Marseille)
Claire Bonneau
(Institut Curie, Paris)
GYNECOLOGY
SURGERY

J GINECO B You Mars 2016
GINEGEPS objectives and tasks
Creation in 2013
Objective: to participate in translational research and
early phase trials within GINECO
To propose new
hypotheses and lead
translational
research projects
To propose ancillary
translational studies
in GINECO trials
To design early
phase trials with
new designs or new
concepts

J GINECO B You Mars 2016
GINEGEPS: strengths and weakness
Strengths
Young motivated physicians or scientists
All subspecialities are incorporated:
•Oncologists and surgeons involved in
- Drug development
- Trials
- Biology
•Pathologists
•Radiologists
•Statisticians
From all parts of France
Support from GINECO
Any
translational
or trial should
be possible !

J GINECO B You Mars 2016
Early phase trials
- MONAVI: ABT 263 => ovaire platine résistant
- ENDOLA: ENDOxan métronomique +
OLAparib + metformine => endomètre
- VICTORIA: AZD2014 + anastrozole, =>
endomètre